pregnancy jaundice

Question 1

what is intrahepatic cholestasis known as

Answer 1

obstetric cholestasis

Question 2

which trimester is it seen intrahepatic cholestasis of pregnancy

Answer 2

3rd

Question 3

features of intrahepatic cholestatsis of pregnancy

Answer 3

pruritus, often in the palms and soles
no rash (although skin changes may be seen due to scratching)
raised bilirubin

Question 4

Mx of obstetric cholestasis

Answer 4

ursodeoxycholic acid is used for symptomatic relief
weekly liver function tests
women are typically induced at 37 weeks

Question 5

complications of intrahepatic cholestasis of pregnancy

Answer 5

an increased rate of stillbirth

Question 6

what is acute fatty liver of pregnancy and when does it occur

Answer 6

Acute fatty liver of pregnancy is rare complication which may occur in the third trimester or the period immediately following delivery.

Question 7

features of acute fatty liver

Answer 7

abdominal pain
nausea & vomiting
headache
jaundice
hypoglycaemia
severe disease may result in pre-eclampsia

Question 8

ix acute fatty liver

Answer 8

ALT is typically elevated e.g. 500 u/l

Question 9

mx of acute fatty liver

Answer 9

support care
once stabilised delivery is the definitive management