Prelim

Question 1

How many days does it take for a megakaryoblast to be mature?

Answer 1

5 days

Question 2

What is a specific hormone responsible for Megakaryopoiesis?

Answer 2

Thrombopoietin

Question 3

Thrombopoietin is produced by the?

Answer 3

Liver

Question 4

It’s a form of mitosis that lacks telophase and cytokinesis

Answer 4

Endomitosis

Question 5

is the process where nuclei divide multiple times without cytoplasmic division, creating giant multinucleated cells. Megakaryocytic cells use this to produce platelets.

Answer 5

Endomitosis

Question 6

resemble lymphocytes and cannot be distinguished by wright-stained light microscopy

Answer 6

Progenitors

Question 7

Least mature specific progenitor

Answer 7

BFU-Meg

Question 8

Most mature specific progenitor

Answer 8

LD-CFU-Meg

Question 9

Least mature precursor

Answer 9

MK-I or Megakaryoblast

Question 10

Most mature precursor

Answer 10

MK-III or Megakaryocyte

Question 11

Endomitosis starts at

Answer 11

LD-CFU-Meg

Question 12

Endomitosis ends at

Answer 12

MK-II or Promegakaryocyte

Question 13

Earlier influences on megakaryopoiesis

Answer 13

GM-CSF, IL-3, IL-6, IL-11, KIT ligand, and TPO

Question 14

What is the main site of production of TPO?

Answer 14

Liver

Question 15

2/3 of the platelets are on the

Answer 15

Circulation

Question 16

1/3 of the platelets are found on the

Answer 16

Spleen

Question 17

major source of energy of platelets

Answer 17

GLUCOSE/DEXTROSE

Question 18

It’s composed of the membranes and is responsible for platelet adhesion and aggregation

Answer 18

PERIPHERAL ZONE

Question 19

Provides the structure for maintaining the circulating discoid shape of the cell, and also maintains the position of the organelles

Answer 19

SOL-GEL ZONE

Question 20

It controls platelet shape change, extension of
pseudopods, and secretion of granules

Answer 20

Microtubules, actin microfilaments, and intermediate microfilament

Question 21

Promote coagulation

Answer 21

HMWK, FIBRINOGEN, FV, FVIII:Vwf

Question 22

Promote aggregation

Answer 22

ADP, CALCIUM. PLT FACTOR 4

Question 23

Promote vasoconstriction

Answer 23

Serotonin & Thromboxane A2

Question 24

Promote vascular repair

Answer 24

PLT derived growth factor & beta thromboglobulin

Question 25

Other systems affected

Answer 25

Plaminogen, alpha 2 antiplasmin, C1esterase inhibitor

Question 26

The stoppage of blood flow

Answer 26

Hemostasis

Question 27

It is process that retains the blood within the vascular system during periods of injury, localizes the reaction involved in the site of injury, and repairs and re-establishes blood flow through the injured vessel.

Answer 27

Hemostasis

Question 28

To maintain the circulatory Hemostasis is achieved through the process of balancing

Answer 28

Bleeding (hemorrhage) & clotting (thrombosis)

Question 29

It’s initiated by the exposure of platelets to the subendothelial connective tissue components blood vessels (Collagen, microfilaments, basement membranes).

Answer 29

Primary hemostasis

Question 30

Inhibits Platelet activation A vasodilator that is synthesized through the eicosanoid pathway

Answer 30

Prostacyclin (PGI2) Prostacyclin (PGI2)

Question 31

Stimulates vasodilation

Answer 31

ATP

Question 32

Endothelial surface receptor for thrombin Binds and inactivates thrombin and enhances anticoagulant and fibrinolytic action of protein C found in the plasma

Answer 32

Thrombomodulin

Question 33

Coats the endothelial cell surface and weakly enhances activity of anti-thrombin III, a plasma procoagulant

Answer 33

Heparan Sulfate

Question 34

Converts plasminogen to plasmin, which plays important role in fibrinolysis

Answer 34

Tissue plasminogen activator (tPA)

Question 35

Storage site of vwf in endothelium

Answer 35

Weibel Palade

Question 36

Storage site of vwf in platelets

Answer 36

alpha granules

Question 37

-A platelet inhibitor and a vasodilator that is synthesized through the eicosanoid pathway

Answer 37

*Prostacyclin

Question 38

vascular “relaxing” factor -Relaxes smooth muscle and subsequent vasodilation, inhibits platelet activation, and promotes angiogenesis and healthy arterioles

Answer 38

*Nitric Oxide

Question 39

- A regulator of the extrinsic pathway of coagulation

Answer 39

TFPI

Question 40

glycosaminoglycan that enhances the activity of antithrombin, a blood plasma serine protease inhibitor

Answer 40

*Heparan Sulfate

Question 41

-A protein C activator

Answer 41

*Thrombomodulin

Question 42

Activates fibrinolysis

Answer 42

TPA

Question 43

The entire molecule as it circulates in the plasma. Composed of VIII:C and VIII: vWF

Answer 43

VIII/vWF

Question 44

Portion of molecule responsible for binding to endothelium and supporting normal platelet adhesion and function. Tested by bleeding time

Answer 44

VIII: vWF

Question 45

Portion of molecule acting in intrinsic system as cofactor to factor IXa (with Ca++) in the conversion of factor X to Xa. Tested by APTT

Answer 45

VIII: C

Question 46

Antigenic property of procoagulant portion as measured by immunologic monoclonal antibody techniques

Answer 46

VIIIC:Ag

Question 47

Factor VIII-related antigen, which is a property of the large vWF portion of the molecule and measured by immunologic techniques of Laurel rocket or immunoradiometeric assay.

Answer 47

VIIIR:Ag

Question 48

Ristocetin (an antibiotic no longer used therapeutically) cofactor activity, which is factor VIII-related activity required for aggregation of human platelets with ristocetin in in vitro aggregation studies.

Answer 48

VIII: RCo

Question 49

Major inhibitor of blood coagulation. Activated protein C is a strong anticoagulant and degrades factor Va and VIIIa and stimulates fibrinolysis by inactivating plasminogen activator inhibitors

Answer 49

Protein C

Question 50

Servers as cofactor with protein C.

Answer 50

Protein S

Question 51

Major inhibitor of thrombin.

Answer 51

Antithrombin C

Question 52

ANTITHROMBIN 3 Enhanced BY?

Answer 52

Heparin

Question 53

Forms complex with thrombin, kallikrein, and plasmin thus inhibiting their activities

Answer 53

Alpha 2 macroglobulin