PREMID

Question 1

buccal drug delivery systems are used for both sublingual and buccal drug
delivery

Answer 1

FALSE

Question 2

injection of a drug directly into the patient’s veins is the most rapid route of
administration, resulting in the most rapid onset of action.

Answer 2

Intravenous

Question 3

injected deeply into muscle tissue

Answer 3

Intramuscular

Question 4

administered by mouth

Answer 4

Oral

Question 5

This route is convenient to use in children or in patients who are unconscious or vomiting.

Answer 5

Rectal

Question 6

are applied to a surface area of the body

Answer 6

Dermal

Question 7

The drug is absorbed through the skin into the bloodstream. -Systemic Effect

Answer 7

TRUE

Question 8

Process by which a chemical or drug becomes dissolved in a solvent

Answer 8

Dissolution

Question 9

Major transmembrane process for most drug

Answer 9

Passive Diffusion

Question 10

The effect of reduced particle size of a drug is:

Answer 10

a. increased absorption

Question 11

Dissolution rate tests can be used to predict bioavailability if:

Answer 11

a. dissolved drug remains free in the GIT

Question 12

Differences in bioavailability are most
frequently observed with drugs are
administered by which of the ff.
routes

Answer 12

Oral

Question 13

The major pathway of excretion

Answer 13

via the kidney

Question 14

The rate of diffusion of drug across biological membranes is most commonly:

Answer 14

directly proportional to the concentration gradient

Question 15

The rectal route of administration may be preferred over the oral route for some drug because:

Answer 15

a portion of the absorbed drug does not
pass through the liver before entering the systemic circulation

Question 16

The process that determines absolute
bioavailability are the first pass effect and:

Answer 16

Absorption

Question 17

In LADMER system, L stands for liberation as the first step which determines the following aspects, except:

Answer 17

Type of Preparation

Question 18

The ultimate evaluation of dosage forms or delivery system is in:

Answer 18

Clinical effectiveness

Question 19

A rate limiting factor in the dissolution of
drugs is: a. disintegration of the tablet

Answer 19

TRUE

Question 20

A rate limiting factor in the dissolution of
drugs is:

Answer 20

Disintegration of tablet

Question 21

The effect of reduced particle size of a drug is: all of them

Answer 21

NO

Question 22

The effect of reduced particle size of a drug is:

Answer 22

Increased Absorption

Question 23

Tmax means:

b. peak height concentration

Answer 23

NO

Question 24

Tmax means:

Answer 24

Time of Peak Concentration

Question 25

The purpose of biotransformation reaction is: a. deactivate the drug b. preserve the drug from destruction c. promote elimination of inactive drug d. a & c answer -d

Answer 25

YES

Question 26

The advantage of sublingual/buccal administration is:

Answer 26

a. no occurrence of gastrointestinal degradation c. not pass to the liver

Question 27

A site in the biophase to which drug molecules can be found is:

Answer 27

Receptor

Question 28

The rectal route of administration may be preferred over the oral route for some drug because:

Answer 28

a portion of the absorbed drug does not pass through the liver before entering the systemic circulation

Question 29

The rectal route of administration may be preferred over the oral route for some drug because: b. absorption is predictable and complete

Answer 29

NO

Question 30

it classifies drugs into four classes according to their ---------- across the gastrointestinal pH range and their --------------- across the gastrointestinal mucosa. answer solubility and permeability

Answer 30

YES

Question 31

Solubility and permeability are considered as the major physicochemical factors that affect the rate and extent of oral drug absorption.

Answer 31

YES

Question 32

If the volume of aqueous media taken to dissolve the drug in pH conditions ranging from 1 to 8 is greater than 250 mL then the drug is considered to have ---------- answer is high solubility

Answer 32

NO

Question 33

If the volume of aqueous media taken to dissolve the drug in pH conditions ranging from 1 to 8 is greater than 250 mL then the drug is considered to have ---------- answer is low solubility

Answer 33

YES

Question 34

which class of the BCS is the following? High solubility/high permeability Dissolve rapidly when presented in immediate-release dosage forms. Rapidly transported across the gut wall. Rapidly absorbed = good bioavailability. BCS class I Drugs

Answer 34

YES

Question 35

which class of the BCS is the following? • Hydrophilic molecules (high aqueous solubility) with low permeability across the biological membranes. answer is BCS Class IV drugs

Answer 35

NO

Question 36

which class of the BCS is the following? • Hydrophilic molecules (high aqueous solubility) with low permeability across the biological membranes. answer is BCS Class III drugs

Answer 36

YES

Question 37

design feature of the dosage form that affects the delivery of the drug; such a system may protect the stomach or delay the release of the active Drug Delivery System

Answer 37

TRUE

Question 38

dosage form that contains a special coating designed to delay absorption of the medication and to resist breakdown by acidic gastric fluids - delayed-release (DR) formulations

Answer 38

TRUE

Question 39

tablet or capsule designed to reduce frequency of dosing compared with immediate-release and most sustained- release formulations

Answer 39

extended-release (XL) formulation

Question 40

science that examines interrelationship of physiochemical properties of drug, dosage form in which drug is given, and route of admin on rate and extent of systemic drug absorption -Biopharmaceutics

Answer 40

TRUE

Question 41

study of adverse effects of drugs and toxic substances in body

Answer 41

Clinical toxicology

Question 42

difference between onset time and time at which drug declines back to MEC

Answer 42

Duration of Drug action

Question 43

Branch of medicine and biology concerned with the study of drug action

Answer 43

Pharmacology

Question 44

Pharmacology can mainly be divided into two main areas, namely

Answer 44

Pharmacokinetics and Pharmacodynamics

Question 45

LADMER process can be divided into 2: -Drug Input and Drug output

Answer 45

TRUE

Question 46

input process

Answer 46

Liberation and Absorption

Question 47

release of drug from its dosage form

Answer 47

Liberation

Question 48

biopharmaceutics involves factors that influence: o stability of drug within drug product o release of drug from drug product o rate of dissolution/release of drug at absorption site o systemic absorption of drug

Answer 48

ALL

Question 49

In LADMER system, L stands for liberation as the first step which determines the following aspects, except: a. onset of action c. rate of absorption b. type of preparation d. bioavailability

Answer 49

type of preparation

Question 50

The termination of action of a drug is determined by: a. excretion of intact active molecule c. tissue redistribution b. excretion of active molecule d. a & c

Answer 50

D

Question 51

The rate and extent at which the drug appears in the bloodstream is known as:

Answer 51

Bioavailability

Question 52

The principal site of drug metabolism is:

Answer 52

liver

Question 53

The first step which determines the onset of action, rate of absorption, availability is:

Answer 53

liberation

Question 54

Which is the following factors affect the dissolution in the lipid membrane of the lipid soluble unionized fluid compartment: a. pH c. lipid/water partition coefficient b. pKa d. all of the above

Answer 54

D

Question 55

When considering drug transport, 'a passive transport process' implies that: a. all of the drug will pass from one compartment to another b. the process requires energy c. The net transfer of drug is from an area of high concentration to an area low concentration d. the net transfer of drug is from an area of low concentration to an area of high concentration

Answer 55

C

Question 56

Reabsorption of the drugs and its metabolite occurs in the a. kidney c. both a & b b. intestines d. none of the above

Answer 56

C

Question 57

Gastric emptying is slowed down by the following except: a. a vigorous exercise c. hot meals b. fatty foods d. hunger

Answer 57

D

Question 58

Oral dosage forms are widely used due to the convenience of drug administration.

Answer 58

TRUE

Question 59

Orally bioavailable means that a drug or other substance that is taken by mouth can be absorbed and used by the body.

Answer 59

TRUE

Question 60

Plendil ER is an example of release delayed tablet

Answer 60

FALSE

Question 61

Liberation is the first step in determining onset of action, rate of absorption, availability

Answer 61

TRUE

Question 62

A drug administered in a dosage form by any route of administration must be released from the dosage form (except IV, and true solutions for other routes).

Answer 62

TRUE

Question 63

A lower pKa value indicates a weak acid.

Answer 63

FALSE

Question 64

A higher pKa value indicates a stronger acid.

Answer 64

FALSE

Question 65

Most of the drugs are absorbed or transported by passive diffusion, depends

Answer 65

lipid solubility

Question 66

iN THE LADMER SYSTEM D IS

Answer 66

Distribution

Question 67

WHAT THE PHARMACEUTICAL SCIENTIST DOES TO THE DRUG REFERS TO

Answer 67

BIOPHARMACEUTICS

Question 68

deals with the study of physiochemical and physiological factors that influence the liberation and absorption of drugs from different dosage forms

Answer 68

BIOPHARMACEUTICS

Question 69

the two most important biopharmaceutical properties that influence drug absorption and oral bioavailability.

Answer 69

DRUG SOLUBILITY AND PERMEABILITY

Question 70

as the amount of drug that passes into solution when an equilibrium is established between the drug solute in solution and any excess, un-dissolved drug to produce a saturated solution at a specified temperature

Answer 70

DRUG SOLUBILITY

Question 71

THE STUDY OF DRUG RESPONSE

Answer 71

Pharmacodynamics

Question 72

The ability of a drug or other substance to be absorbed and used by the body

Answer 72

BIOAVAILABILITY

Question 73

WHICH OF THE FOLLOWING STATEMENT IS TRUE? o In order for a drug to be absorbed, it must be present in the form of solution o After dissolution, the drug diffuses to the site of absorption o Only drugs administered intravenously in solution enter the circulatory system immediately.

Answer 73

o ALL THE ABOVE IS TRUE

Question 74

In the liver, the main place of metabolism, some drugs are inactivated and metabolized during the first pass; other drugs are activated here

Answer 74

TRUE

Question 75

Poor biopharmaceutical and pharmacokinetic properties can affect drug responses.

Answer 75

true

Question 76

Drugs with good aqueous solubility and membrane permeability generally show good oral absorption and bioavailability provided the drug is stable in the gastrointestinal tract and does not undergo first-pass metabolism in the liver

Answer 76

true