PREMIX EXAM

Question 1

The oldest record of the use of therapeutic plants and minerals are derived from the ancient civilizations of the _____, ______ the _____ of _______ and the _______ people of _____.

Answer 1

CHINESE, HINDUS, MAYANS
CENTRAL AMERICA
MEDITERRANEAN, ANTIQUITY

Question 2

He compiled a book about herbs in 2735 BC.

Answer 2

SCHOLAR EMPEROR SHEN NUNG

Question 3

An antimalarial alkaloid

Answer 3

CH’ANG SHANG

Question 4

a treatment for hypotension, from which ephedrine was isolated.

Answer 4

MA HUANG

Question 5

The 2 book about herbs from which Scholar Emperor Shen Nung compiled?

Answer 5

CH’ANG SHANG
MA HUANG

Question 6

It is known to the Indigenous American Indians as a treatment for various skin problems such as psoriasis and eczema.

Answer 6

CHAULMOOGRA FRUIT

Question 7

Chaulmoogra fruit is a treatment for various skin conditions such as?

Answer 7

PSORIASIS AND ECZEMA

Question 8

It contains emetine that was used in Brazil for the treatment of dysentery and diarrhea.

Answer 8

IPECACUANHA ROOT

Question 9

It is a class or medicine used to induces nausea and vomiting for the emergency treatment of poisoning with certain toxins that have been swallowed.

Answer 9

EMETIC AGENTS

Question 10

The early explorers found out that the South American Indians chewed ________ (containing ____) and used ______ (containing ______) as a hallucinogens.

Answer 10

COCOA LEAVES (COCAINE)
MUSHROOMS (TRYPTAMINE)

Question 11

Non-synthetic narcotic herbs

Answer 11

OPIUM

Question 12

An expectorant herb in the drugs of antiquity.

Answer 12

SQUILL

Question 13

Can treat pain and insomnia, and a local anesthetic) in the drugs of Antiquity.

Answer 13

HYOSCYAMUS

Question 14

4 herbs that can be found in the ancient greek apothecary shops:

Answer 14

OPIUM
SQUILL
HYOSCYAMUS
VIPER TOXIN

Question 15

Metallic drugs found in the ancient greek apothecary shops:

Answer 15

COPPER
ZINC ORES
IRON SULFATE
CADMIUM OXIDE

Question 16

In what year when Scholar Emperor Shen Nung compiled a book about herbs?

Answer 16

2735 BC

Question 17

He uses Antimony as a purgative and gained much popularity after it was used to cure Louis XIV

Answer 17

PARACELSUS (PHILIPPUS AUREOLUS THEOPHRASTUS BOMBASTUS von HOHENHEIM)

Question 18

It is used to treat people infected with types of parasites; such as prople who have schistosomiasis.

Answer 18

ANTIMONY

Question 19

Complete name of Paracelsus?

Answer 19

PHILIPPUS AUREOLUS THEOPHRASTUS BOMBASTUS von HOHENHEIM

Question 20

In what year did Paracelsus used antimony as purgative?

Answer 20

1493-1541

Question 21

Who did Paracelsus cured by using the Antimony?

Answer 21

LOUIS XIV

Question 22

They refined and extended the technique of chemical analysis. The emphasis was shifted from finding new medicaments from the vast world of plants to finding the active ingredients that accounted for their pharmacologic properties.

Answer 22

EUROPEAN CHEMISTS

Question 23

A German Chemist who synthesized acetic acid in 1845.

Answer 23

HERMANN KOLBE

Question 24

A french chemist who synthesized methane in 1856.

Answer 24

PIERRE-EUGÈNE-MARCELLIN BERTHELOT

Question 25

He isolated morphine in 1803.

Answer 25

FRIEDRICH WILHELM SERTÜRNER

Question 26

He isolated emetine in 1816.

Answer 26

PIERRE-JOSPEH PELLETIER

Question 27

He isolated emetine in 1816. Also had a significant contribution in the purification of caffeine (CNS stimulant), quinine (anti-malarial), colchicine (anti-gout) in 1820.

Answer 27

PIERRE-JOSEPH PELLETIER

Question 28

CNS stimulant

Answer 28

CAFFEINE

Question 29

anti malarial in 19 century

Answer 29

QUINONE

Question 30

ACUTE ANTI-GOUT ARTHRITIS

Answer 30

COLCHICINE

Question 31

Chronic anti-gout arthritis

Answer 31

ALLOPURINOL

Question 32

An English Physician and Botany, who used digitalis as a treatment for dropsy.

Answer 32

WILLIAM WITHERING

Question 33

A german chemist who isolated cocaine in 1860, and the active ingredient physostigmine from the calabar bean in 1864.

Answer 33

ALBERT NEIMANN

Question 34

PABA

Answer 34

PARA-AMINOBENZOIC ACID

Question 35

He reported that the red dyestuff (2,4 diaminoazobenzene, 4-sulfonamide) dramatically cured dangerous systemic GRAM POSITIVE BACTERIAL INFECTIONS in man and animals

Answer 35

DOMAGK

Question 36

It is the first antibacterial drug (introduced in 1935) and the first sulfonamide antibiotics.

Answer 36

PRONTOSIL

Question 37

They observed that the bacteriostatic action of sulfonamide-like drugs was antagonized by PABA.

Answer 37

WOODS AND FIDES

Question 38

What year did Wood and Fides observe the bacteriostatic action of sulfonamide like drugs.

Answer 38

1940

Question 39

In what year di the first antibacterial drug (prontosil) introduced?

Answer 39

1935

Question 40

In what year did Albert Neimann isolated Coacaine?

Answer 40

1860

Question 41

In what year did Pierre-Joseph Pelletier isolated Emetine?

Answer 41

1816

Question 42

In what year did Pierre-Eugène-Marcellin Berthelot synthesized methane?

Answer 42

1856

Question 43

In what year was Hermann Kolbe synthesized the acetic acid?

Answer 43

1845

Question 44

Pennicillin was discovered by?

Answer 44

ALEXANDER FLEMING

Question 45

When was Penicillin discovered?

Answer 45

1928

Question 46

Discovery of penicillin (B lactam antibiotic) by Alexander Fleming in 1928 and its subsequent examination by ______ and ______ in 1938.

Answer 46

HOWARD FLOREY ERNST CHAIN

Question 47

When was florey’s team successfully cured an infected mice with penicillin?

Answer 47

MAY 25, 1940

Question 48

Chemical structure of Prontosil.

Answer 48

C12H13N5O25

Question 49

Penicillin is known as the war’s _______, curing infectious disease and saving millions of lives.

Answer 49

“MIRACLE DRUG”

Question 50

In what year did Alexander Fleming, Ernst Chain, Howard Florey were awarded the Noble Prize in Physiology or Medicine “for the discover of penicillin and it curative effect in various infectious diseases”

Answer 50

1945

Question 51

It is used to modify the mood and mental states of psychiatric patients.

Answer 51

STIMULANTS AND DEPRESSANTS

Question 52

_____, _____ and ______ were used to stimulate or depress the mental states of a patient

Answer 52

AMPHETAMINE SEDATIVES HYPNOTICS

Question 53

A treatment for schizophrenia by charpentier.

Answer 53

CHLORPROMAZINE

Question 54

Where did Charpentier first synthesized the molecule in 1950?

Answer 54

RHONE-POUCLENC’S RESEARCH LABORATORY

Question 55

He reported distinctive effects on animal behavior

Answer 55

SIMON COURVOISIER

Question 56

He first synthesized the molecule on 1950 at RHONE-POULENC’S RESEARCH LABORATORY.

Answer 56

CHARPENTIER

Question 57

He is a french millitary surgeon who first noticed distinctive psychotropic effects in man.

Answer 57

HENRI LABORIT

Question 58

A french psychiatrists who clearly outlined what was now become its accepted use in psychiatry and without whose endorsement and prestige, Rhone-Poulenc might never have developed further as an antipsychotic.

Answer 58

JEAN DENIKER and JEAN DELAY

Question 59

CPZ or chlorpromazine became available as?

Answer 59

LARGACTIL

Question 60

The first pure hormone to be isolated from an endocrine gland was?

Answer 60

EPINEPHRINE

Question 61

Epinephrine which led to further molecular modifications in the area of?

Answer 61

SYMPATHOMIMETIC AMINES

Question 62

In 1914, He isolated thyroxine (T4) from the thyroid gland?

Answer 62

EDWARD KENDALL

Question 63

In what year did edward kendall isolated thyroxine from the thyroid gland?

Answer 63

1914

Question 64

He subsequently won the Nob Prize in Physiology or Medicine in 1950 for his discovery of Cortisone?

Answer 64

EDWARD KENDALL

Question 65

Edward Kendall subsequently won the Nob Prize in Physiology or Medicine in 1950 for his discovery of ______?

Answer 65

CORTISONE

Question 66

It is the major achievement in drug discovery and development in 1921 from animal sources.

Answer 66

discover of INSULIN

Question 67

When was the major achievement in the discovery of Insulin.

Answer 67

1921

Question 68

It is created by our pancreas, it regulated our body’s metabolism of carbohydrates, fats and proteins.

Answer 68

INSULIN

Question 69

A Canadian biochemist and the pharmaceutical industry, were able to purify and produce animal-based insulin in large quantities.

Answer 69

JAMES B COLLIP

Question 70

In what year did the researchers, with the help of James B Collip, a canadian biochemist and the pharmaceutical industry, were able to purify and produce animal-based insulin in large quantities

Answer 70

1922

Question 71

______found that for hundred of years, Mexican women had been eating ______ of the _____ for ______.

Answer 71

RUSELL MARKER WILD YAMS DIOSCOREA GENUS CONTRACEPTION

Question 72

It is abundant in yams and has a similar structure to progesterone.

Answer 72

DIOSGENIN

Question 73

When did Rusell Marker discovered that for hundred of years, Mexican Women had been eating wild yams?

Answer 73

1930

Question 74

A chemist working at the Syntex Laboratories in Mexico City, sythesized norethindrone.

Answer 74

CARL DJERASSI

Question 75

The first orally active contraceptive steroid, by a subtle modification of the structure of progesterone.

Answer 75

NORETHINDRONE

Question 76

The first use of synthetic organic chemicals for the modulation of life processes occurred when _____, ____ and ______were introduced in anesthesia in 1840’s.

Answer 76

NITROUS OXIDE ETHER CHLOROFORM

Question 77

a dentist in Hartford, Connecticut administered nitrous oxide during a tooth extraction.

Answer 77

HORACE WELLS

Question 78

A dentist in HartFord, Connecticut administered nitrous oxide during a tooth extraction.

Answer 78

HORACE WELLS

Question 79

A Georgia physician, employed ether as an anesthetic for excising the growth on a patient’s neck.

Answer 79

CRAWFORD LONG

Question 80

A dentist, who gave the first successful public demonstration of surgical anesthesia on ______, at the surgical amphitheater that us now called Ether Dome in Massachusetts, General Hospital.

Answer 80

WILLIAM MORTON OCOTOBER 16, 1846

Question 81

That name of the surgical theater now?

Answer 81

ETHER DOME ON MASSACHUSETTS GENERAL HOSPITAL

Question 82

In what year did William Morton gave the first successful public demonstration of surgical anesthesia?

Answer 82

OCTOBER 16, 1846

Question 83

He popularized the use of opium in Europe.

Answer 83

PARACELSUS

Question 84

An alcoholic solution of opium known as _____, was the first method of administration.

Answer 84

LAUDANUM

Question 85

In what century did paracelsus popularized the use of opium in Europe.

Answer 85

SIXTEENTH CENTURY

Question 86

It was first isolated in pure crystalline form from opium in 1805.

Answer 86

MORPHINE

Question 87

He is the German Apothecary who name the compound ‘morphium’ after ‘morpheus’ the greek god of Dreams

Answer 87

FRIEDRICH W. SERTÜRNER

Question 88

The greek god of Dreams

Answer 88

MORPHEUS

Question 89

Alcohol extract of opium

Answer 89

LAUDANUM

Question 90

Since antiquity, alcoholic beverages and potions containing laudanum, an alcoholic extract of opium, and various other plant products have been used to ______.

Answer 90

INDUCE SLEEP

Question 91

were used in the middle of the nineteenth century as a sedative/hypnotic, as was chloral hydrate, paraldehyde, urethane and sulfenal.

Answer 91

BROMIDE

Question 92

was synthesized by the Bayer Pharmaceutical Company and introduced to the market under the name Luminol.

Answer 92

PHENOBARBITAL

Question 93

they synthesized phenobarbital and was introduced to the market under the name luminol.

Answer 93

BAYER PHARMACEUTICAL COMPANY

Question 94

Phenobarbital was introduced to the mark under the name?

Answer 94

LUMINOL

Question 95

The compound was effective as a hypnotic but it also exhibited anticonvulsant properties.

Answer 95

PHENOBARBITAL

Question 96

The modification of barbituric acid molecule led to the development of?

Answer 96

HYDANTOINS

Question 97

Phenytoin is also known as?

Answer 97

DIPHENYLHYDANTOIN OR DILANTIN

Question 98

Phenytoin was first synthesized in what year?

Answer 98

1908

Question 99

not a sedative at ordinary doses, it established that anti-seizure drugs need not induce drowsiness.

Answer 99

PHENYTOIN

Question 100

the anticonvulsant properties of phenytoin was not discovered until?

Answer 100

1938

Question 101

Chemical structure of Barbiturates

Answer 101

C4H3N2O3

Question 102

Chemical structure of hydantoin

Answer 102

C3H4N2O2

Question 103

Chemical structure of phenytoin

Answer 103

C15H12N2O2

Question 104

Induced in the category are _____, _____ , _____ and _____ used in the treatment of myocardial ischemia, pharmacotherapy of congestive heart failure, arrhythmia and hypercholesteromia.

Answer 104

DIURETICS VASSOPRESIN RENIN ANGIOTENSIN DRUGS

Question 105

was attributed to William Withering, who in 1775 discovered that the foxglove plant, Digitalis Purpurea was beneficial to those suffering from abnormal fluid buildup.

Answer 105

DIGOXIN

Question 106

Digoxin was attributed to?

Answer 106

WILLIAM WITHERING

Question 107

When was digoxin was attributed to William Withering?

Answer 107

1775

Question 108

In 1775, William Withering discovered that the _____, ____ was beneficial to those suffering from Abnormal fluid buildup.

Answer 108

FOXGLOVE PLANT, DIGITALIS PURPUREA

Question 109

The active principles of digitalis were isolated in ____ by ____, _____ in Paris. These active priciples consisted mainly of Digitoxin

Answer 109

1841 E. HUMOLLE T. QUEVENNE

Question 110

Cholesterol lowering drugs

Answer 110

STATINS

Question 111

One of the cornerstones in the prevention of both primary and secondary heart diseases.

Answer 111

STATINS

Question 112

The discovery of statins can be credited to this research scientist at Sankyo Pharmaceuticals in Japan.

Answer 112

AKIRA ENDO

Question 113

What was the first effective leukemia drug?

Answer 113

6-MERCAPTOPURINE

Question 114

Who developed the first leukemia drug, 6 mercaptopurine.

Answer 114

GEORGE HITCHINGS GERTRUDE ELION

Question 115

Who is the technician of George Hitchings in the development of 6 mercaptopurine?

Answer 115

GERTRUDE ELION

Question 116

Who discovered cisplatin as a cancer treatment?

Answer 116

BARNETT ROSENBERG, PhD

Question 117

When did Barnett Rosenberg, PhD discovered cisplatin as a treatment for cancer?

Answer 117

1965

Question 118

Cisplatin was synthesized in ____ by Barnett Rosenberg.

Answer 118

1845

Question 119

It is now the gold standard against which new medicines are compared,

Answer 119

CISPLATIN

Question 120

A second generation compound which has less toxicity and fewer side effects.

Answer 120

CARBOPLATIN