Pressors

Question 1

What is the primary effect of α-1 adrenergic receptors?

Answer 1

Vasoconstriction

Question 2

What are the primary effects of β-1 receptors?

Answer 2

Chronotropy and inotropy

Question 3

What is the primary effect of β-2 receptors?

Answer 3

Vasodilation

Question 4

What is the primary effect of most subtypes of dopamine receptors?

Answer 4

Vasodilation

Question 5

What is the first-line pressor for septic shock?

Answer 5

norepinephrine

Question 6

Which receptors does NE act on?

Answer 6

α-1 and β-1

Question 7

What are the primary effects of NE?

Answer 7

vasoconstriction and a modest increase in CO

Question 8

Which receptors does phenylephrine act on?

Answer 8

almost purely α-1

Question 9

What are the primary effects of phenylephrine?

Answer 9

vasoconstriction (minimal cardiac inotropy or chronotropy

Question 10

What is a potential disadvantage of phenylephrine?

Answer 10

decreased stroke volume

Question 11

What receptors does Epi act on?

Answer 11

primarily β-1 + moderate β-2 and α-1

Question 12

What is the effect of Epi at low doses?

Answer 12

Increased CO w/ no change (or decrease) in SVR

Question 13

What is the effect of Epi at higher doses?

Answer 13

increased CO + increased SVR

Question 14

What are the risks of Epi?

Answer 14

dysrhythmias and splanchnic vasoconstriction

Question 15

What receptors does dopamine act on in low doses (1-2 mcg/kg/min)?

Answer 15

dopamine-1

Question 16

What is the effect of dopamine at low doses?

Answer 16

splanchnic vasodilation

Question 17

What receptors does a medium dose of dopamine act on?

Answer 17

β-1

Question 18

What is the effect of medium-dose dopamine?

Answer 18

increased CO

Question 19

What receptors does high-dose dopamine act on?

Answer 19

α-1

Question 20

What is the predominant effect of high-dose dopamine?

Answer 20

vasoconstriction

Question 21

What is the main risk of dopamine?

Answer 21

tachyarrhythmias

Question 22

What is a reason why you might use dopamine over NE?

Answer 22

bradycardia

Question 23

What receptors does dobutamine act on predominantly?

Answer 23

β-1

Question 24

What is the effect of dobutamine?

Answer 24

increased CO and reduced SVR

Question 25

What is the primary effect of isoproterenol?

Answer 25

increased chronotropy

Question 26

What pressor would be good for a patient with septic shock and tachyarrhythmias?

Answer 26

phenylephrine

Question 27

What agent should be added (say to NE) for septic shock when the adrenergic effect is insufficient?

Answer 27

vasopressin

Question 28

What is the first-line pressor for hypodynamic shock?

Answer 28

NE

Question 29

What is the first-line pressor for anaphylactic shock?

Answer 29

Epi