Primary Pharmacotherapy Approach in Psychiatric Disorders Flashcards Preview

Pharm list for Neuro Exam 4 > Primary Pharmacotherapy Approach in Psychiatric Disorders > Flashcards

Flashcards in Primary Pharmacotherapy Approach in Psychiatric Disorders Deck (14)
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1

Goal of pharmacotherapy in Alzheimers

Increase ACh activity
Decrease Glu excitotixicity

2

Goal of pharmacotherapy in Acyte-Chronic Pain

Increase NE-5HT
Decrease PG formation

3

Goal of pharmacotherapy in Parkinson's Disease

Increase DA activity
Decrease in ACh activity

4

Goal of pharmacotherapy in Seizure Disorder

Increase in GABA (BDZs, Barbs)

Block VSSC (Carbamazepine, Phenytoin)

Block VSCC (Lamotrigine)

T-Ca2+ Channel blocker (Ethosuximide)

5

Goal of pharmacotherapy in Psychoses

Block D2 receptor (Haloperidol)

Block 5HT receptor (Clozapine)

**Nicotinic agonists also help, which is why many ppl with Schizophrenia smoke**

6

Goal of pharmacotherapy in Depression

Increase synaptic levels of 5HT, NE, and DA

DAT inhibitor: Buproprion
MAO inhibitor: Phenelzine
SERT inhibitor: Fluoxetine
SERT-NE inhibitor: Venlafaxine

7

Goal of pharmacotherapy in Mania

Modulate NT activity (Lithium inhibits release of DA, NE and 5HT)
Block VSSC (Valproate)
Block VSCC (Lamotrigine)

8

Goal of pharmacotherapy in Anxiety

Enhance 5HT (Buspirone)
Enhance GABA (BNDz
SERT anagonist (Fluoxetine)

9

Goal of pharmacotherapy in ADHD

Inhibit DAT (Amphetamine-Methylphenidate)
Inhibit NET (Atomoxetine)
Increase alpha2 (Clonidine)

10

Goal of pharmacotherapy in Insomnia

Increase GABA (Zolpidem, Benzodiazepines)
Decrease ACh
Decrease Histamine (Diphenhydramine)
5HT2A antagonist (Trazadone)

11

Goal of pharmacotherapy in General Anesthesia

Increase GABA (Isoflurane, Barbs)
Decrease NMDA
GLU inhibition (Ketamine, NO)

12

Treatment of Opioid substance use disorder

Methadone: long-acting opioid agonist
Buprenorphine: partial opioid agonsit + naloxone, can cause seizures)
Naltrexone

13

Treatment of Alcohol substance use disorder

Disulfiram: Inhibits acetaldehyde dehydrongenase (makes you sick!!!)

Naltrexone: opioid antagonish

Acamprosate: GABA antagonist

14

Treatment of Nicotine use

Nicotine replacement therapy

Bupropion: Nicotinic receptor antagonist/DA reuptake inhibitor

Varenicline: partial a4b2 agonist, may cause suicidal ideation and depression