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Pharm list for Neuro Exam 4 > Primary Pharmacotherapy Approach in Psychiatric Disorders > Flashcards

Primary Pharmacotherapy Approach in Psychiatric Disorders Flashcards

1
Q

Goal of pharmacotherapy in Alzheimers

A

Increase ACh activity

Decrease Glu excitotixicity

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2
Q

Goal of pharmacotherapy in Acyte-Chronic Pain

A

Increase NE-5HT

Decrease PG formation

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3
Q

Goal of pharmacotherapy in Parkinson’s Disease

A

Increase DA activity

Decrease in ACh activity

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4
Q

Goal of pharmacotherapy in Seizure Disorder

A

Increase in GABA (BDZs, Barbs)

Block VSSC (Carbamazepine, Phenytoin)

Block VSCC (Lamotrigine)

T-Ca2+ Channel blocker (Ethosuximide)

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5
Q

Goal of pharmacotherapy in Psychoses

A

Block D2 receptor (Haloperidol)

Block 5HT receptor (Clozapine)

Nicotinic agonists also help, which is why many ppl with Schizophrenia smoke

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6
Q

Goal of pharmacotherapy in Depression

A

Increase synaptic levels of 5HT, NE, and DA

DAT inhibitor: Buproprion
MAO inhibitor: Phenelzine
SERT inhibitor: Fluoxetine
SERT-NE inhibitor: Venlafaxine

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7
Q

Goal of pharmacotherapy in Mania

A 
Modulate NT activity (Lithium inhibits release of DA, NE and 5HT)
Block VSSC (Valproate)
Block VSCC (Lamotrigine)
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8
Q

Goal of pharmacotherapy in Anxiety

A 
Enhance 5HT (Buspirone)
Enhance GABA (BNDz
SERT anagonist (Fluoxetine)
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9
Q

Goal of pharmacotherapy in ADHD

A 
Inhibit DAT (Amphetamine-Methylphenidate)
Inhibit NET (Atomoxetine)
Increase alpha2 (Clonidine)
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10
Q

Goal of pharmacotherapy in Insomnia

A 
Increase GABA (Zolpidem, Benzodiazepines)
Decrease ACh 
Decrease Histamine (Diphenhydramine)
5HT2A antagonist (Trazadone)
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11
Q

Goal of pharmacotherapy in General Anesthesia

A 
Increase GABA (Isoflurane, Barbs)
Decrease NMDA
GLU inhibition (Ketamine, NO)
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12
Q

Treatment of Opioid substance use disorder

A

Methadone: long-acting opioid agonist
Buprenorphine: partial opioid agonsit + naloxone, can cause seizures)
Naltrexone

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13
Q

Treatment of Alcohol substance use disorder

A

Disulfiram: Inhibits acetaldehyde dehydrongenase (makes you sick!!!)

Naltrexone: opioid antagonish

Acamprosate: GABA antagonist

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14
Q

Treatment of Nicotine use

A

Nicotine replacement therapy

Bupropion: Nicotinic receptor antagonist/DA reuptake inhibitor

Varenicline: partial a4b2 agonist, may cause suicidal ideation and depression

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Pharm list for Neuro Exam 4 (2 decks)

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