Primer 7 Flashcards

1
Q

Waist to hip circumference for men should be less than

  1. 25
  2. 5
  3. 8
  4. 95
A

0.95

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2
Q

Waist to hip circumference for women should be less than

  1. 25
  2. 5
  3. 8
  4. 95
A

0.8

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3
Q

Measuring the skinfold of the triceps helps estimate body _____ composition

Muscle
Fat
Protein
water

A

Fat

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4
Q

Measuring the midarm muscle circumference estimates body ________ composition

Muscle
Fat
Protein
water

A

Muscle

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5
Q

Urinary excretion of which 2 metabolites estimates total body muscle mass?

1-Methylhistidine
3-Methylhistidine
Creatinine
Creatine

A

3-Methylhistidine and CREATININE

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6
Q

Total body nitrogen content is indicated by

BUN
Creatinine
Bilirubin
N2 measurement

A

BUN

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7
Q

Urea is formed in the _________ and excreted by the _______.

A

Liver, kidneys

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8
Q

Elevated BUN indicates which type of organ failure?

Renal
Hepatic
Splenic
Colonic

A

Renal (not being excreted well)

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9
Q

Low BUN indicates which type of organ disease?

Renal
Hepatic
Splenic
Colonic

A

Hepatic…likely enough not being formed

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10
Q

Body protein reserves are reflected in the concentration of which serum component?

Bilirubin
Creatine
Albumin
Globulin

A

Albumin

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11
Q

A serum albumin level under _____ suggests protein malnutrition, GI inflammation, digestive in capacity, edema in the extremities, CHF, acute liver disease, ecclampsia of pregnancy, or protein loss due to renal dysfunction.

< 5.5

  1. 5
  2. 5
  3. 5
A

< 5.5

serum albumin concentration <3.5 g/dL is indicative of malnutrition in an elderly individual.

Serum albumin concentrations less than 3.5 g/dL often accompany dehydration or hypothyroidism.

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12
Q

Serum albumin less than _____ often accompanies dehydration or hypothyroidism

<5.5
<4.5
<3.5
<2.5

A

<3.5

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13
Q

Serum osteocalcin, serum total and bone alk phos, serum type 1 collagen propeptide are markers of

Bone resorption
Bone formation
Bone density
Bone cancer

A

Bone formation

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14
Q

Urinary pyridinoline and urinary hydroxyproline, along with plasma tartrate-resistant acid phosphatase activity are markers of

Bone resorption
Bone formation
Bone density
Bone cancer

A

Bone resorption

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15
Q

Dehydration of cells, due to hypernatremia, can cause dry mucous membranes and sunken eyeballs, but much more dangerous issues when cerebral cells become dehydrated. Sx of cerebral cellular dehydration are

A

Restlessness, apprehension, coma

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16
Q

Hyperkalemia can cause disturbances of

Skeletal muscle
Cardiac muscle
Both

A

Both

17
Q

Abdominal distension, bloating, constipation, nausea, vomiting, general lethargy, muscle weakness, lack of normal reflex, increased cardiac contractility and elevated BP are signs of which?

Hypernatremia
Hypercalcemia
Hypermagnesemia
Hyperkalemia

A

Hypercalcemia

18
Q

What is the appropriate blood pH range?

A

7.35-7.45

19
Q

What occurs when increased blood CO2 elevates plasma H2CO3 (carbonic acid) and decreases the ratio of H2CO3 to HCO3(-) {bicarbonate ion} in plasma to less than 1:20?

Metabolic Acidosis
Respiratory Acidosis
Metabolic Alkalosis
Respiratory Alkalosis

A

Respiratory acidosis

Respiratory Acidosis occurs when increased blood CO2 concentration in turn elevates plasma H2CO3 concentration and decreases the ratio of H2CO3 to HCO3- in plasma to less than 1:20. The usual cause is pulmonary disease that impairs the ability to excrete CO2. In uncompensated respiratory acidosis, plasma HCO3- concentration remains in the normal range and plasma pH falls below 7.35.

In compensated respiratory acidosis, urinary excretion of acid is increased, in turn elevating plasma HCO3- concentration, restoring a 1:20 ratio of the plasma concentrations of H2CO3 andHCO3 - and returning plasma pH to 7.35-7.45.

20
Q

What occurs when alterations in metabolism generate increases amounts of organic acids that lower plasma pH, which increases the production of H2CO3?

Metabolic Acidosis
Respiratory Acidosis
Metabolic Alkalosis
Respiratory Alkalosis

A

Metabolic acidosis

Metabolic Acidosis occurs when alterations in metabolism generate increased amounts of non- volatile organic acids that lower plasma to pH to below 7.35. The increased plasma acidity upsets the equilibrium between H2CO3 and HCO3-, increasing the production of H2CO3 and resulting in a ratio of H2CO3 to HCO3- in plasma of less than 1:20.

Increased respiratory excretion of CO2 can compensate for increasing acid production, returning plasma CO2 and HCO3- concentrations, the plasma H2CO3 to HCO3- ratio and plasma pH to normal.

21
Q

What occurs when CO2 excretion by the lungs causes decreased plasma CO2 concentration, leading to low levels of HCO3(-) and a ratio of H2CO3 to HCO3(-) in plasma greater than 1:20?

Metabolic Acidosis
Respiratory Acidosis
Metabolic Alkalosis
Respiratory Alkalosis

A

Respiratory alkalosis

Respiratory Alkalosis occurs when increased pulmonary excretion of CO2 causes decreased plasma CO2 concentration, leading to depression of plasma HCO3- concentration, a ratio of H2CO3 to HCO3- in plasma greater than 1:20 and elevation of plasma pH to above 7.45.

Increased excretion of alkaline urine can restore the plasma ratio of H2CO3 to HCO3- to 1:20 and return plasma pH to the normal range.

22
Q

What occurs when metabolic alterations generate depress HCO3 (-) levels and a ratio of H2CO3 to HCO3(-) of greater than 1:20, decreased plasma CO2?

Metabolic Acidosis
Respiratory Acidosis
Metabolic Alkalosis
Respiratory Alkalosis

A

Metabolic Alkalosis

Metabolic Alkalosis occurs when alterations in metabolism generate increased amounts of alkali, leading to depression of plasma HCO3- concentration, a ratio of H2CO3 to HCO3- in plasma greater than 1:20, decreased plasma CO2 concentration and elevation of plasma pH to above 7.45.

Decreased respiratory excretion of CO2 can restore the plasma ratio of H2CO3 to HCO3 - to 1:20 and return plasma pH to the normal range.

23
Q

PKU nutritional therapy involves a diet low in phenylalanine and high in which amino acid?

Tryptophan
Tyrosine
Methionine
Arginine

A

Tyrosine. PKU is caused by a deficiency of the enzyme phenylalanine hydroxylase which converts Phe to Tyr. Since Phe won’t be converted, need to avoid it and replace Tyr since it can’t be generated

24
Q

Tyrosenemia type 1 causes hypertyrosenemia, which causes rickets and potentially fatal hepatomegaly. Nutritional therapy is based on diets low in which 2 amino acids?

A

Phe and Tyr, because Phe is coverted to Tyr.

25
Q

Cystathione synthase defect causes which metabolic issue that leads to increased CVD and mental retardation?

hypercystathionemia
hypermethionemia
hyperhomocysteinemia
hyperglycemia

A

hyperhomocysteinemia

26
Q

Which amino acid should be avoided or restricted in a situation of cystathionine-beta-synthase defect?

Tryptophan
Cysteine
Methionine
Arginine

A

Methionine (converted to Hcys)

The CBS gene provides instructions for making an enzyme called cystathionine beta-synthase. This enzyme acts in a chemical pathway and is responsible for using vitamin B6 to convert building block of proteins (amino acid) called homocysteine and serine to a molecule called cytathionine.

27
Q

Glycogen Storage Disease Type 1a is due to a defect in ________. This causes which two primary symptoms?

Hyperglycemia and hepatomegaly
Hypoglycemia and hepatomegaly
Hyperglycemia and splenomegaly
Hypoglycemia and splenomegaly

A

glucose-6-phosphatase

Hypoglycemia and hepatomegaly (enlarged liver)

28
Q

Effective nutritional therapy for Glycogen Storage Disease Type 1a is a diet with ________ fat and ________ complex carbs

Low, low
Low, high
high, low
High, high

A

Low, high