Principles of Pharmacology

Question 1

Define pharmacokinetics.

Answer 1

effect of a body on the drug (bioavailability, absorption, distribution, elimination)

Question 2

Define pharmacodynamics.

Answer 2

effect of the drug on the body (side effects, therapeutics, mechanism of action)

Question 3

List determinants of distribution.

Answer 3

• size of target
• blood flow
• solubility
• binding to receptors

Question 4

Contrast zero and first order elimination.

Answer 4

• First Order: elimination of drug is dependent on concentration of drug in circulation
• Zero Order: elimination of druge is independent of concentration of drug in circulation

Question 5

Describe multicomponent distribution.

Answer 5

drug is distributed to many different compartments (blood, tissues, neurons, etc.)

• undergoes a distribution phase as it equilibrates among these compartments
• then, it undergoes an elimination phase
• both phases have their own half life

Question 6

Describe single component distribution.

Answer 6

drug is only distributed to the vascular compartments of the body

Question 7

Define Type I, II, and II Receptors.

Answer 7

Type I - plasma membrane (ACh, norepi)
Type II - cytoplasm (steroids)
Type III - nuclear (anticancer drugs)