Propanolol Hydrochloride (Antihypertensive) Flashcards
(19 cards)
What are the brand names for propanolol hydrochloride?
Inderal (LA) & Innopran XL
What strength tablets of propranolol hydrochloride are available?
10mg, 20mg, 40mg, 60mg, 80mg
What strength capsules propanolol hydrochloride sustained release are available?
60mg, 80mg, 120mg, 160mg
What strength injection solution of propranolol hydrochloride is available?
1 mg/mL
What strength oral solution of propranolol hydrochloride is available?
40 mg per 5 mL
What dose of propanolol Hydrochloride is used for the treatment of hypertension?
80mg per day in a single or divide dose, up to 640 mg per day and in divides doses or 120 to 160 mg daily (SR)
What dose of propanolol hydrochloride is used for the treatment of arrhythmias?
Oral: 10mg to 30mg 3 to 4 times a day before meals and at bedtime
Parenteral: Reserve to life-threatening arrhythmias or during anesthesia. Usual dose is 1 to 3mg under careful monitoring. If necessary give a second dose after minutes. Thereafter, do not give additional doses within four hours..
What dose of Inderal is used for the treatment of angina pectoris?
30 to 160mg daily in divided doses or once daily (SR)
What dose of Innopran XL is used for the treatment of migraine headache?
80 to 240mg per day in divided doses or once daily (SR)
What dose of propranolol hydrochloride is used for the treatment of myocardial infarction?
180 to 240 mg per day in 2 to 3 doses
What dose of propranolol hydrochloride is used for the treatment of hypertrophic sub-aortic stenosis?
20 to 40mg 3 to 4 times a day before food and a bedtime OR 80 to 160mg once daily (SR)
What dose of Inderal is used for the treatment of pheochromocytoma?
30mg per day in divided doses
What dose of propranolol hydrochloride is used preoperatively in surgical procedures?
60 mg per day in divided doses for three days prior to surgery.
What should the providers monitor when the patient is taking Inderal?
Blood pressure
What is the mechanism of action for propranolol hydrochloride?
It is a nonselective blockage of beta-adrenergic receptors a.k.a. a beta blocker
What are the drug interactions for Inderal?
- May decrease effects of theophylline or clonidine.
- Barbiturates or rifampin may decrease effects.
- Cimetidine may increase serum levels.
- Hydralazine, propafenone, thioamines, or phenothiazines may increase effects.
- NSAIDs may decrease effects.
- Toxic effects may be increased with verapamil.
- Severe hypertension occurs with epinephrine.
- May increase toxic affects of ergot alkaloids or lidocaine. - Use with prazosin may increase postural hypotension
What are the contraindications of propranolol hydrochloride?
- Use is contraindicated in patients with cardiogenic shock, bronchial asthma, sinus bradycardia, greater than first-degree heart block, and congestive heart failure, unless secondary to tachyarrhythmia treatable with propanolol.
- Use with caution in pregnant or nursing mothers, in patients with impaired renal or hepatic function, bronchospasmic diseases, diabetes mellitus, and thyrotoxicosis.
- Pregnancy Category C
What are the adverse effects of Inderal?
Dizziness, fatigue, lightheadedness, nausea, vomiting, bronchospasm, bradycardia, and peripheral vascular insufficiency.
What should the RPh tell the patient when counseling on propanolol hydrochloride?
- If a dose is missed, take it as soon as possible. If it is closer to the time of your next dose than the dose you missed, skip the missed dose and return to your dosing schedule. Do not double dose.
- May cause drowsiness. Use caution while operating machinery or when mental alertness is required.
- Patients with diabetes need to be aware that this agent can cause masking of hypoglycemic symptoms
- Avoid OTC cough, cold, and allergy medications unless otherwise directed
