Propofol flashcards

Question 1

The 4 desired effects of general anesthesia

Answer 1

hypnosis, amnesia, analgesia, immobility

Question 2

The intravenous anesthetic provides all four of the desired effects of general anesthesia without side effects

Answer 2

none

Question 3

Balanced anesthesia

Answer 3

Using smaller doses of multiple drugs to provide anesthesia rather than using larger doses of one or two drugs

Question 4

The most frequently administered anesthetic drug for induction of anesthesia

Answer 4

Propofol

Question 5

Other uses of propofol besides induction of general anesthesia

Answer 5

Sedation and to a lesser extent it is used to prevent nausea and vomiting

Question 6

Propofol chemically is

Answer 6

2,6 diisopropylphenol

Question 7

Propofol is metabolized by

Answer 7

70% liver 30% Lungs

Question 8

Metabolites of Propofol are active or inactive

Answer 8

inactive

Question 9

Metabolites of Propofol are excreted via

Answer 9

Kidneys

Question 10

Wake up from a single dose of Propofol occurs within _____ minutes

Answer 10

8-10 minutes

Question 11

Termination of the effects of Propofol are due to

Answer 11

Redistribution of the drug from highly perfused organs (brain) to lesser perfused organs/tissues

Question 12

Sterile technique is especially important when working with Propofol because

Answer 12

the available formulation supports bacterial growth

Question 13

An open vial of Propofol should be discarded after

Answer 13

6 hours

Question 14

Patients with what allergy may be allergic to Propofol

Answer 14

Eggs. Propofol contains egg yolk lecithin

Question 15

What effects does Propofol have on the central nervous system

Answer 15

Hypnosis, sedation, decreased cerebral blood flow, decreased cerebral metabolic requirement for oxygen, decreased intracranial pressure, decreased intraocular pressure, burst suppression on the EEG, anticonvulsant

Question 16

The analgesic properties of Propofol are

Answer 16

Nonexistent

Question 17

Propofol during periods of focal ischemia is

Answer 17

neuroprotective

Question 18

Occasional excitatory effects of Propofol seen on induction of anesthesia with Propofol are

Answer 18

twitching and spontaneous movement

Question 19

Propofol’s effect on systemic arterial blood pressure

Answer 19

Propofol produces a larger decrease in systemic arterial blood pressure than any other drug used for induction of anesthesia

Question 20

Propofol’s effect on peripheral vasculature

Answer 20

Profound vasodilatation of both arterial and venous circulation

Question 21

Propofol’s effect on the myocardium

Answer 21

Unclear

Question 22

Propofol’s effect on preload

Answer 22

Propofol reduces preload

Question 23

Propofol’s effect on afterload

Answer 23

Propofol reduces afterload

Question 24

Propofol’s effect on the elderly

Answer 24

Propofol’s reduction in blood pressure is more pronounced in the elderly, especially those with reduced intravascular volume

Question 25

Propofol's effect on the baroreceptor response

Answer 25

Propofol markedly inhibits the normal baroreflex response and produces only a small increase in heart rate, thus further exacerbating its hypotensive effect.

Question 26

Propofol can induce arrhythmias they are

Answer 26

Bradycardia and asystole can occur in healthy adults despite prophylactic anticholinergics

Question 27

Propofol's effect on respiration after an induction dose

Answer 27

Propofol's respiratory depressant effects often produce apnea following an induction dose.

Question 28

Propofol's effect on respiration during a maintenance infusion

Answer 28

Propofol reduces minute volume both my decreases in respiratory rate and tidal volume. The decrease in tidal volume is more pronounced.

Question 29

Propofol's effect on upper airway reflexes

Answer 29

Propofol reduces airway reflexes more than pentothal making it well suited for instrumentation of the airway (intubation)

Question 30

Wheezing after Propofol versus Pentothal

Answer 30

Propofol decreases the incidence of wheezing after induction of anesthesia and tracheal intubation in healthy and asthmatic patients.

Question 31

Propofol dose for induction of general anesthesia in healthy adults

Answer 31

1-2.5 mg/kg IV

Question 32

Propofol dose for induction of general anesthesia in children

Answer 32

2.5-3.5 mg/kg IV

Question 33

Continuous infusion rate of Propofol for IV sedation

Answer 33

25-75 mcg/kg/min

Question 34

Antiemetic dose of Propofol

Answer 34

10-20 mg

Question 35

Propofol side effect noted on injection

Answer 35

Pain on injection

Question 36

The presumed mechanism of action of propofol is through

Answer 36

potentiation of the chloride current mediated throught he gamma-aminobutyric acid type A (GABA type A) receptor complex

Question 37

What is the beta half-life of Propofol?

Answer 37

4-23 hours