Prosopagnosia

Question 1

DeHann, Young & Newcombe, 1987

Answer 1

Patient PH: associative prosopagnosia. Could match to FRU but not PIN

Question 2

Schweinberger (1998)

Answer 2

Identity can affect expression judgements

Question 3

Bauer 1984; Tranel & Damasio 1985

Answer 3

PPAs = higher SCRs to familiar faces

Question 4

Bate 2010

Answer 4

Oxytocin improves face recognition in DPs. Modulates distributed face processing network, particularly the amygdala

Question 5

Domes 2010

Answer 5

Oxytocin modulates FFA in face emotion processing task

Question 6

Haxby 2000

Answer 6

OFA = initial visual face processing, FFA = facial identity, STS = changeable aspects e.g. emotion

Question 7

Delvenne 2004

Answer 7

Associate PPA was actually perceptual

Question 8

Avidan 2014

Answer 8

DPs = no composite effect

Question 9

Duchaine 2006

Answer 9

Edward = no face inversion effect

Question 10

Barton 2009

Answer 10

Apperceptive PPAs: configural deficit (for face stimuli and dot patterns) - although some evidence of whole-object processing

Question 11

Lobmaier 2010

Answer 11

DPs = disrupted face-specific, configural processing (impaired for blurred faces but not blurred objects or scrambled faces etc)

Question 12

Van Belle 2010

Answer 12

Acquired PPA = patient PS had abnormal eye gaze exploration patterns so reflects feature-based processing approach

Question 13

Biotti 2017

Answer 13

Highly significant composite effect in DPs

Question 14

Yovel & Duchaine 2006

Answer 14

PPAs impaired for both shapes and features and spacing between them

Question 15

Witthoft 2016

Answer 15

DPs had smaller pRF sizes in ventral face network that rarely extended to ipsilateral or peripheral VF = impaired spatial integration of facial features

Question 16

Johnston and Morton 1991

Answer 16

Babies innate ability to attend to faces

Question 17

Farah 1995

Answer 17

Faces = within-category so harder. But not just due to this as created OR task of comparable difficulty and PPAs still worse at faces

Question 18

Moscovitch 1997

Answer 18

CK: visual agnosia but no PPA

Question 19

Sergent and Signoret 1992

Answer 19

RM Impaired for faces but not cars

Question 20

McNeill and Warrington 1993

Answer 20

WJ PPA for human faces but not sheep faces

Question 21

Duchaine and Yovel 2006

Answer 21

Edward (DP) = impaired at faces but not within-category objects so mechanisms for each = separate developmental processes

Question 22

Rangarajan 2014

Answer 22

EBS to right FFA only = deficits in conscious face perception e.g. distortion of faces, while left FFA = non-face related aspects e.g. colour changes

Question 23

Jonas 2014

Answer 23

EBS to right (but not left) OFA = impaired face discrimination

Question 24

Hadjikhani 2002

Answer 24

PPAs (1 DP, 2 AP) did not show normal increase in FFA or OFA fMRI activation in response to faces (objects and faces had similar activation)

Question 25

Avidan 2005

Answer 25

DPs showed normal FFA activation (although could be disconnection syndrome? Could be continuum?) FFA detection only, full recognition requires activation of anterior temporal semantic stores. But: Grill-Spector 2004. Could be feedback mechanisms?

Question 26

Dalrymple 2011

Answer 26

No N170 if both OFA and FFA. Spared if only bilateral FFA damaged. Also patient with only STS damage only showed impairment when expression changed. So need at least two components of FP network spared?

Question 27

Schiltz 2006

Answer 27

Damaged OFA = reduced responses in FFA (feedback)

Question 28

Barton 2003

Answer 28

Posterior occipital lesions = perceptual deficits (impaired structural and matching to FRUs), anterior temporal = can't extract semantic info (match to PIN)

Question 29

Gomez 2015; Song 2015

Answer 29

DPs had abnormal white matter around FFA so disconnection syndrome?

Question 30

Renzi 2013

Answer 30

Right DLPFC is involved in holistic processing. DPs show higher fMRI activity in this area = compensatory (but ineffective) mechanism?

Question 31

Cattaneo 2016

Answer 31

Polymorphisms in OXTR associated with DP

Question 32

Fisher 2017

Answer 32

DPs = attenuated N250 in identity matching task. | Identity-specific deficit.

Question 33

Johnen 2014

Answer 33

Family of DPs: all showed varying severity of PPA and general visual deficits. Continuum!

Question 34

Avidan & Behrmann 2008

Answer 34

DPs better at familiar face matching than unfamiliar. | = covert recognition

Question 35

Eimer 2012

Answer 35

DPs had intact N250 (occipito-temporal) for non-recognised famous faces, but no P600f. Suggests disconnection between intact identity-specific memory and later semantic stages, which are necessary for full FR.

Question 36

Grill-Spector 2004

Answer 36

Differential FFA activation for face detection vs face identification tasks.

Question 37

Barton 2003

Answer 37

Anterior temporal lesions = worse at task involving extraction of long-term memory representations / mental imagery.