Prostate Cancer Flashcards

1
Q

What is the prostate? What does it do?

A

small gland in men

produces seminal fluid that nourishes and transports sperm

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2
Q

Prostate cancer may cause no sign or symptoms in early stages: T/F?

A

True

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3
Q

Early or more advanced prostate cancer causes signs and symptoms?

A

more advanced

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4
Q

symptoms of prostate cancer?

A
trouble urinating
decreased force in urine stream
blood in urine or semen
bone pain
losing weight w/o trying
ED
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5
Q

Why is bone pain a possible symptom of prostate cancer?

A

bones are a likely met site for prostate cancer

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6
Q

Common risk factors for prostate cancer:

A

age (>50)
Race (most common in AA and have more severe cancers)
FHx
Obesity

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7
Q

What blood test is used to screen for prostate cancer?

A

PSA

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8
Q

What is PSA? normal range? What if it’s elevated?

A

protein produced by noncancerous and cancerous cells

<3-4ng/mL

elevated PSA could indicate prostate cancer, enlarged or inflamed prostate

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9
Q

What screening method is done in addition to PSA?

A

digital rectal exam

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10
Q

What must be completed if PSA or digital rectal exam come back abnormal?

A

a prostate biopsy

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11
Q

What else can PSA tell us?

A

measuring levels after treatment has begun, can tell us if therapy is working or if need to switch

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12
Q

What is PSA doubling time?

A

amount of time it takes for someone’s PSA levels to double

if 3mo or less, prognosis seems to be worse compared to other

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13
Q

What scoring system is used for prostate cancer?

A

Gleason

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14
Q

What type of biopsy is used in prostate cancer?

A

core biopsy

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15
Q

Describe the process of Gleason scoring:

A

graded 1-5 based on how differentiated (look normal) the cells are

1/2 are often not used (typically 3 or higher)

highest score is 10

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16
Q

How are Gleason scores often written?

A

+=_

17
Q

Why do Gleason scores often have multiple numbers added together?

A

prostate cancer often have areas with different grades

18
Q

What makes the first and second numbers in a gleason score different?

A

the first is the predominant type of cell in the sample

19
Q

What Gleason score range is poorl diff./high grade? intermediate? low?

A

8-10

7

6

20
Q

What are some common treatments for prostate cancer?

A

Lupron

enzalutamide

21
Q

What hormone can prostate cancer be sensitive to?

A

testosterone

22
Q

What are some limitations of somatic testing of tumors?

A

not all genes/gene of interest are on the panel

panel may screen gene of interest but not cover it all

23
Q

What is TMZ?

A

temozolomide: alkyating agent which causes cell death

24
Q

What status can impact effectiveness of TMZ?

A

MGMT methylation

if methylated -> TMZ effective

if not methylated -> TMZ less effective