Prostate Cancer Flashcards
T/F: men castrated before puberty do not develop cancer
True
T/F: prostate cancer does not respond to hormonal deprivation
False, it does respond to hormonal deprivation
At what stage do you start to see obstructive sx of prostate cancer?
Late stages
What are the 2 main dx used to detect prostate cancer?
DRE
PSA
What 3 instances would you do a DRE in?
- prostate issues
2, blood in stool
- rectal cancer
DRE: General principles:
Any ______ nodule needs to be considered for biopsy
Any _____________ nodule needs to be correlated with the PSA
hard
questionable
What position must the pt be in when performing the DRE?
kneeling position
DRE is useful for approximating the __________
size of the prostate gland
Which part of the prostate can we access during a DRE?
Why is this so useful to us?
peripheral zone
this is the zone where prostate cancer is most common
The following are physiological properties of what?
Serine protease
Produced by epithelial cells lining the
aciniand ducts of the prostate gland
Secreted in the seminal fluid, very little
should enter the general circulation
Liquefaction of the seminal coagulum
PSA
The median increase in serum PSA
after routine DRE is clinically insignificant/significant?
INSIGNIFICANT
What is PSA velocity and why is it significant?
change in PSA concentration over a period of time
may detect early prostate cancer before detection through other methods
What is PSA density and why is it significant?
serum PSA concentration/prostate volume (divided by)
May be helpful in differentiating prostate cancer from BPH
T/F: PSA is prostate specific not prostate cancer specific
TRUE
T/F: PSA following DRE is accurate and reliable
True
