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Pharmacology- week 8 , non-inflammatories > Prostoglandins (PGs) > Flashcards

Prostoglandins (PGs) Flashcards

1
Q

MoA of NSAIDs

A

inhibition of cyclooxygenase (COX) enzymes.
* Reduction in eicosanoid formation from arachidonic acid
→ ↓ prostaglandins synthesis (↑ eukotrienes synthesis)

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2
Q

Non-inflmatory drugs include?

A

1) NSAIDs
2) Glucocorticoids

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3
Q

MoA of PGE2

A

prominant in inflammatory respone –> mediator of fever and pain
- Inhibition of gasteric acid secretion
- Relaxation if broncial, vascular and GI tract SM

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4
Q

MoA of PGI1 (Prostacyclin)

A

vasodilatation and inhibition of platelet aggregation

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5
Q

MoA of PGF2a

A

1) contraction of the uterus
2) decreases intraocular pressure

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6
Q

MoA of PGD2

A

vasodilatation and inhibition of platelet aggregation

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7
Q

category of Misoprostol

A

PGE1

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8
Q

indication of Misoprostol

A

protective action on gastric mucosa

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9
Q

MoA of Misoprostol

A

Prostaglandin
receptor
agonists.

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10
Q

PK/PD of Misoprostol

A
  1. Misoprostol –> a metabolically stable
    prostaglandin (PG)E analogue.
    - It has the potential risk to induce
    abortion     in pregnant women à therefore,
    the drug is contraindicated during
    pregnancy
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11
Q

Adverse effects of Misoprostol

A

Contraindicated In pregnancy,
unless –> used as an abortifacient(misoprostol in combination with mifepristone)

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12
Q

indication of Alprostadil

A
  1. Erectile dysfunction.
  2. Maintain ductus arteriosus potency
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13
Q

MoA of Aloprostadil

A

Prostaglandin receptor agonists.

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14
Q

PK/PD of Alprostadil

A
  1. Vasodilation –> for impotent males to
    treat erectile dysfunction.
  2. Maintains potency of ductus arteriosus
    in neonates until surgical correction in
    neonates with certain congenital heat
    malformations
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15
Q

Indication of Dinoprostone

A
  1. “cervical ripening”.
    (Induction of labor)
  2. As abortifacient
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16
Q

MoA of Dinoprostone

A

Uterine Smooth muscle contraction
inducer

17
Q

category of Carboprost

A

PGF2a

18
Q

indication of Carboprost

A
  1. Abortifacient.
  2. Postpartum uterine bleeding
19
Q

MoA of Carboprost

A

Uterine andbronchiolar SM
contraction inducer

20
Q

PK/PD of Carboprost

A

Bronchiolar SM contractor

21
Q

indication of Latanoprost/Travoprost

A

open angle glaucoma –eye drops

22
Q

MoA of Latanoprost/Travoprost

A

↓ intraocular pressure

23
Q

PK/PD of Latanoprost/Travoprost

A
  1. Vasodilation and increased vascular permeability.
  2. Sensitization of nociceptive fibers
24
Q

Category of Eproprostenol/ Treprostinil

A

PGI2

25
Q

indication of Eproprostenol/ Treprostinil

A

pulmonary hypertension.
(pulmonary atrial
hypertension)

25
Q

MoA of Epoprostenol/Treprostinil

A
  1. Inhibition of platelet aggregation.
  2. Vasodilation
26
Q

Adverse effects of Epoprostenol

A
  1. Dizziness.
  2. headache
  3. flushing.
  4. fainting
27
Q

PK/PD of Epoprostenol

A
  1. Potent pulmonary vasodilators.
  2. Prod significant reduction in pulmonary arterial resistance with a subsequent increase in cardiac index and oxygen delivery.
  3. Short half-life
28
Q

Administration of Treprostinil

A

Orally or inhaled form.

29
Q

Category of Iloprost

A

PGI2

30
Q

indication of Iloprost

A

pulmonary hypertension.
(pulmonary atrial
hypertension)

31
Q

PK/PD of Illoprost

A
  1. Inhaled form only.
  2. Short half-life.
  3. Required frequent dosing due to it
32
Q

Adverse effects of Iloprost

A

Bronchospasm and cough after inhaltion

33
Q

A non-inflammatory drug used to maintain the treatment of Asthma

A

Zileuton –> Lipoxygenase inhibitor

34
Q

Category of Zileuton

A

Lipoxygenase Inhibitor

35
Q

Indication of Zileuton

A

maintaining treatment of asthma

36
Q

MoA of Zileuton

A

Inhibits 5- lipoxygenase.

Pharmacology- week 8 , non-inflammatories (3 decks)

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