Prostoglandins (PGs)

Question 1

MoA of NSAIDs

Answer 1

inhibition of cyclooxygenase (COX) enzymes.
* Reduction in eicosanoid formation from arachidonic acid
→ ↓ prostaglandins synthesis (↑ eukotrienes synthesis)

Question 2

Non-inflmatory drugs include?

Answer 2

1) NSAIDs
2) Glucocorticoids

Question 3

MoA of PGE2

Answer 3

prominant in inflammatory respone –> mediator of fever and pain
- Inhibition of gasteric acid secretion
- Relaxation if broncial, vascular and GI tract SM

Question 4

MoA of PGI1 (Prostacyclin)

Answer 4

vasodilatation and inhibition of platelet aggregation

Question 5

MoA of PGF2a

Answer 5

1) contraction of the uterus
2) decreases intraocular pressure

Question 6

MoA of PGD2

Answer 6

vasodilatation and inhibition of platelet aggregation

Question 7

category of Misoprostol

Answer 7

PGE1

Question 8

indication of Misoprostol

Answer 8

protective action on gastric mucosa

Question 9

MoA of Misoprostol

Answer 9

Prostaglandin
receptor
agonists.

Question 10

PK/PD of Misoprostol

Answer 10

1. Misoprostol –> a metabolically stable
   prostaglandin (PG)E analogue.
   - It has the potential risk to induce
   abortion in pregnant women à therefore,
   the drug is contraindicated during
   pregnancy

Question 11

Adverse effects of Misoprostol

Answer 11

Contraindicated In pregnancy,
unless –> used as an abortifacient(misoprostol in combination with mifepristone)

Question 12

indication of Alprostadil

Answer 12

1. Erectile dysfunction.
2. Maintain ductus arteriosus potency

Question 13

MoA of Aloprostadil

Answer 13

Prostaglandin receptor agonists.

Question 14

PK/PD of Alprostadil

Answer 14

1. Vasodilation –> for impotent males to
   treat erectile dysfunction.
2. Maintains potency of ductus arteriosus
   in neonates until surgical correction in
   neonates with certain congenital heat
   malformations

Question 15

Indication of Dinoprostone

Answer 15

1. “cervical ripening”.
   (Induction of labor)
2. As abortifacient

Question 16

MoA of Dinoprostone

Answer 16

Uterine Smooth muscle contraction
inducer

Question 17

category of Carboprost

Answer 17

PGF2a

Question 18

indication of Carboprost

Answer 18

1. Abortifacient.
2. Postpartum uterine bleeding

Question 19

MoA of Carboprost

Answer 19

Uterine andbronchiolar SM
contraction inducer

Question 20

PK/PD of Carboprost

Answer 20

Bronchiolar SM contractor

Question 21

indication of Latanoprost/Travoprost

Answer 21

open angle glaucoma –eye drops

Question 22

MoA of Latanoprost/Travoprost

Answer 22

↓ intraocular pressure

Question 23

PK/PD of Latanoprost/Travoprost

Answer 23

1. Vasodilation and increased vascular permeability.
2. Sensitization of nociceptive fibers

Question 24

Category of Eproprostenol/ Treprostinil

Answer 24

PGI2

Question 25

indication of Eproprostenol/ Treprostinil

Answer 25

pulmonary hypertension. (pulmonary atrial hypertension)

Question 25

MoA of Epoprostenol/Treprostinil

Answer 25

1. Inhibition of platelet aggregation. 2. Vasodilation

Question 26

Adverse effects of Epoprostenol

Answer 26

1. Dizziness. 2. headache 3. flushing. 4. fainting

Question 27

PK/PD of Epoprostenol

Answer 27

1. Potent **pulmonary vasodilators**. 2. Prod significant **reduction in pulmonary arterial resistance with a subsequent increase in cardiac index and oxygen delivery**. 3. **Short half-life**

Question 28

Administration of Treprostinil

Answer 28

Orally or inhaled form.

Question 29

Category of Iloprost

Answer 29

PGI2

Question 30

indication of Iloprost

Answer 30

pulmonary hypertension. (pulmonary atrial hypertension)

Question 31

PK/PD of Illoprost

Answer 31

1. **Inhaled form only**. 2. **Short half-life.** 3. Required frequent dosing due to it

Question 32

Adverse effects of Iloprost

Answer 32

Bronchospasm and cough after inhaltion

Question 33

A non-inflammatory drug used to maintain the treatment of Asthma

Answer 33

Zileuton --> Lipoxygenase inhibitor

Question 34

Category of Zileuton

Answer 34

Lipoxygenase Inhibitor

Question 35

Indication of Zileuton

Answer 35

maintaining treatment of asthma

Question 36

MoA of Zileuton

Answer 36

Inhibits 5- lipoxygenase.