Protein

Question 1

Imino Acid

Answer 1

Proline

Question 2

With alipathic side chain

Answer 2

Glycine
Alanine
Valine
Leucine
Isoleucine

Question 3

With hydroxylic groups

Answer 3

Serine
Threonine
Tyrosine

Question 4

With sulfur atoms

Answer 4

Cysteine

Methionine

Question 5

With aromatic side chains

Answer 5

Histidine
Phenylalanine
Tyrosine
Tryptophan
Proline

Question 6

With basic groups

Answer 6

Arginine
Lysine
Histidine

Question 7

With acidic groups and amides

Answer 7

Aspartic acid
Asparagune
Glutamic acid
Glutamine

Question 8

Smallest side chain
First step of heme synthesis
Purine synthesis
Inhibitory NT in spinal cord

Answer 8

Glycine

Question 9

Carries nitrogen from peripheral tissues to the liver

Answer 9

Alanine

Question 10

Branched chain amino acid

Accumulate in MSUD

Answer 10

Valine
Isoleucine
Leucine

Question 11

Accumulate in phenylketonuria

Answer 11

Phenylalanine

Phenyllactate, phenylacetate and phenylpyruvate

Question 12

Deficient in PKU

Answer 12

Phenylalanine hydroxylase

Question 13

Longest side chain

Precursor for niacin, serotonin, and melatonin

Answer 13

Tryptophan

Question 14

Precursor of homocysteine

Answer 14

Methionine

Question 15

Uncharged polar side chains

Answer 15

Cysteine
Tyrosine
Serine
Threonine
Asparagine
Glutamine

Question 16

Precursor of thyroxine and melanin; dopa, norepi and epinephrine

Answer 16

Tyrosine

Question 17

Phosphorylation site of enzyme modification

Linked to carbohydrate groups in glycoprotein

Answer 17

Serine

Question 18

Sites for O-linked glycosylation in Golgi apparatus

Answer 18

Serine and threonine

Question 19

With carbonyl group and amide group that can form H-bonds

Answer 19

Asparagine and Glutamine

Question 20

Site for N-linked glycosylation in ER

Answer 20

Asparagine

Question 21

Major carrier of nitrogen to the liver from peripheral tissues
Forms ammonia

Answer 21

Glutamine

Question 22

Acidic side chains

Answer 22

Aspartate

Glutamate

Question 23

Precursor for GABA and glutamate

Answer 23

Glutamate

Question 24

Basic amino acids

Answer 24

Arginine
Lysine
Histidine

Question 25

Used in the diagnosis of folic acid deficiency (N-formiminoglutamate excretion test) Precursor of histamine

Answer 25

Histidine

Question 26

Precursor of creatinine, urea and nitric oxide

Answer 26

Arginine

Question 27

With sulfur

Answer 27

Cysteine | Methionine

Question 28

L-configuration usually found in

Answer 28

AA in protein

Question 29

D-configuration found in:

Answer 29

Bacterial cell wall, antibiotics

Question 30

Chemical compound with net charge of zero

Answer 30

Zwitterion

Question 31

Essential AA

Answer 31

``` Phenylalanine Valine Tryptophan Threonine Isoleucine Methionine Histidine Arginine Leucine Lysine ```

Question 32

Conditionally non-essential

Answer 32

Arginine | Histidine

Question 33

Enzymes for sequencing of: | N-terminal AA

Answer 33

Sanger's (1-fluoro-2,4-dinitrobenzene) | Edman's (Phenylisothiocyanate)

Question 34

Enzymes for sequencing of: | C-terminal AA

Answer 34

Hydrazine | Carboxypeptidase

Question 35

Secondary structure: R handed spiral Parallel to helix Ex.: keratin and hemoglobin

Answer 35

Alpha helix

Question 36

Secondary structure: Sheets H bonds perpendicular to helix Ex.: Amyloid and immunoglobulin

Answer 36

Beta pleated sheets

Question 37

B bends Loop and coil Motifs/ supersecondary

Answer 37

Other Secondary structures

Question 38

Fundamentally functional and 3-d structural units of a polypeptide Formed by combinations of motifs

Answer 38

Domains

Question 39

Specialized groups of proteins required for proper folding of many species of proteins Prevent aggregation Rescue proteins by unfolding hydrophobic regions

Answer 39

Chaperones

Question 40

Hemoglobin of conception up to first few months | At yolk sac

Answer 40

Hb gower

Question 41

Hb at first few months to birth | At liver

Answer 41

Hb F

Question 42

``` Myoglobin vs hemoglobin: 1 polypeptide 1 Oxygen For O2 storage With allosteric effect Hyperbolic curve ```

Answer 42

Myoglobin

Question 43

``` Myoglobin vs Hemoglobin 4 polypeptides 4 Oxygen For O2 transport With allosteric effect Sigmoidal curve ```

Answer 43

Hemoglobin

Question 44

``` Collagen Type Defect Ehler Danlos Osteogenesis Imperfecta Scurvy Alport Menke Epidermolysis Bullosa ```

Answer 44

``` Collagen Type Defect Ehler Danlos - type 3 Osteogenesis Imperfecta - type 1 Alport - type 4 Epidermolysis Bullosa - type 7 ```

Question 45

``` Clinical correlates: Taller and thinner Dolichostenomelia Arachnodactyly Ascending aorta dilation ```

Answer 45

Marfan syndrome

Question 46

Clinical correlates: Hematuria ESRD

Answer 46

Alport syndrome

Question 47

Clinical correlates: Kinky hair Growth retardation

Answer 47

Menke syndrome

Question 48

``` Clinical correlates: Multiple fractures Blue sclera Hearing loss Dental imperfection ```

Answer 48

Osteogenesis imperfecta