Protein Structure Flashcards

(32 cards)

1
Q

What are the key properties of proteins?

A
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2
Q

What is the genral formula for amino acid structure

A
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3
Q

What are the 4 main categories for amino acid classifications?

A
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4
Q

What are non-polar v polar side chains?

A

polar interact better with water

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5
Q

what is the difference between acidic and basic side chains?

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6
Q

What are the steps of polypeptide chain synthesis?

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7
Q

What is peptide bond formation?

A
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8
Q

What happens in chain formation?

A
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9
Q

What are the 4 levels of protein structure?

A
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10
Q

Provide an overview of the primary structure.

A
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11
Q

Provide an overview of the secondary structure.

A
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12
Q

Provide an overview of alpha-helix sheet structure.

A
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13
Q

Provide an overview of beta-sheet structure.

A
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14
Q

Compare parallel and ant antiparallel beta sheet structures

A

parallell - chained lines up in the same polarity, requires looping
antiperallel - run in opposite directions

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15
Q

Provide an overview of tertiary structure.

A
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16
Q

What weak forced stabilise tertiary structures?

17
Q

What strong forces stabilise tertiary structures?

18
Q

Give an overview of quaternary protein structure.

19
Q

What are fibrous protein structures?

20
Q

What are globular protein structures?

21
Q

What forces contribute to protein folding and stability?

22
Q

What is the hydrophobic effect?

23
Q

What is amino acid hydropathy?

A

high values = non-polar (on interior)
low = more likely to be polar (on the exterior)

24
Q

What is ubiquitin?

A

tags other structures for destruction.

25
What is the hydrophobic effect?
- H-bonds - ion pairs or salt bridges - metal ions
26
What are DNA-binding proteins? - examples - interactions (forces) - nomenclature - groove interaction with DNA - binding domains - structural motifs
27
What is a helix-turn-helix structural motif?
28
What is the Lac repressor? - tetramar -> 4 domains
29
What a leucine zipper motif?
- 2 alpha helices - coil w/ in each other
30
What are the main features in the amino acid sequence of the leucine zipper?
31
What is the zinc finger motif? - typical features - DNA groove integration - examples
32
What is TBP?