Protein Structure Flashcards
(26 cards)
What are amino acids linked together by?
Peptide Bonds
Primary
the linear sequence of amino acids in a protein
Secondary
the local 3-dimensional structure of the peptide backbone
Tertiary
the global arrangement of secondary structure, amino acid R groups and prosthetic groups
Quaternary
the arrangement of multiple protein molecules in complexes
N-Terminal
Amino Terminal
C-Terminal
Carboxyl Terminal
What form the peptide “backbone” of proteins?
Atoms of the peptide bonds and alpha-carbnos
Primary structure ______ all other levels of structure
dictates
What are the 4 major classes of secondary structure?
Alpha Helix, Beta sheet, turns, and random coil
Alpha Helix
a helical region of the peptide backbone that is stabilized by hydrogen bonding within the helix
Where are R groups in alpha helices?
Sticking outward
Beta Sheet
a planar arrangement of several peptide backbones that is stabilized by hydrogen bonding to adjacent beta strands
Where are R groups in beta sheets?
Sticking up and down from the beta sheets
In beta sheets, adjacent chains can be _____ or ______.
parallel; antiparallel
What structure interacts to give a protein its tertiary structure?
Secondary
What can portions oof tertiary structure define?
Domains
What energy state are the proteins in their native fold?
Low energy state
Are proteins rigid once folded?
No
Homodimers
Dimers formed between identical polypeptide monomers
Heterodimers
Dimers between different polypeptide monomers
Denature
Protein unfolding/uncoiling
Is primary structure maintained in protein denaturing?
Yes
What does protein denaturation do?
Eliminates enzyme function
