Protein Structure - TRQ

Question 1

Dense hydrophobic cores are typical of…

Answer 1

Globular protein

Question 2

Collagen is found in a(n)…

Answer 2

triple helix

Question 3

Peptide bonds have a structure and geometry which is …

Answer 3

Rigid and planar

Question 4

Secondary structure is stabilized by …

Answer 4

Hydrogen bonds

Question 5

Silk fibroin is found in a(n) …

Answer 5

beta conformation

Question 6

Beta-turns link together two adjacent segments of …

Answer 6

Antiparallel beta sheets

Question 7

A recognizable folding pattern involving two or more elements of secondary structure is called…

Answer 7

Motif

Question 8

a loss of 3-D structure sufficient to cause loss of function is called …

Answer 8

denaturation

Question 9

A part of a polypeptide chain that is independently stable or could undergo movements as a single entity is known as a …

Answer 9

Domain

Question 10

A visual description of the combinations of dihedral angles that are permitted in a peptide backbone is called …

Answer 10

Ramachandran plot

Question 11

An example of a family of chaperones is …

Answer 11

Hsp70

Question 12

An idealized alpha-helix contains how many residues per turn?

Answer 12

3.6 residues/turn

Question 13

Biochemists can estimate the fraction of protein made up of a helix or beta sheet using …

Answer 13

Circular dichroism (CD) spectroscopy

Question 14

In the beta conformation of polypeptide chains, the backbone is extended into a …

Answer 14

Zigzag

Question 15

In alpha-keratins, the cross-links stabilizing quaternary structure are …

Answer 15

Disulfide bonds

Question 16

Most enzymes and regulatory proteins are …

Answer 16

Globular proteins

Question 17

Proteins can be denatured by …

Answer 17

Heat and extremes of pH

Question 18

Proteins in their functional, folded conformations are called …

Answer 18

Native proteins

Question 19

Proteins that catalyze the accurate folding of proteins are called …

Answer 19

Chaperones

Question 20

Proteins with polypeptide chains folded into a spherical or globular shape are called …

Answer 20

Globular proteins

Question 21

Proteins with polypeptide chains arranged in long strands or sheets are called …

Answer 21

Fibrous proteins

Question 22

Proteins with significant similarity primary structure and/or tertiary structure and function are said to be in the same …

Answer 22

protein family

Question 23

Returning to conditions in which the native conformation is stable is called …

Answer 23

Renaturation

Question 24

Since the loss of structure in one part of the protein destabilizes other parts, the process of unfolding is …

Answer 24

Cooperative

Question 25

Some multimeric proteins have a repeated unit consisting of a singe subunit or group of subunits called ...

Answer 25

Protomer

Question 26

The C-N bond in a peptide group cannot rotate freely because of ...

Answer 26

Partial double-bond characters

Question 27

The coiled-coil motif is found in ...

Answer 27

alpha-Keratin

Question 28

The local spatial arrangement of polypeptides is called ...

Answer 28

Secondary structure

Question 29

The spatial arrangement of atoms in a protein or any part of a protein is called its ...

Answer 29

Conformation

Question 30

The arrangement of two or more separate polypeptide chains in 3-D complexes is termed ...

Answer 30

Quaternary structure

Question 31

The elements that connect segments of antiparallel beta sheets are called ...

Answer 31

beta turns

Question 32

The major contributor in stabilizing the globular form of most soluble proteins is ...

Answer 32

Hydrophobic interactions

Question 33

The overall 3-D arrangement of all atoms in a protein, including longer-range aspects of amino acid sequence, is termed ...

Answer 33

Tertiary structure

Question 34

The structures that provide support, shape, and external protection to vertebrates are made of ...

Answer 34

fibrous proteins

Question 35

These proteins constitute hair, nails, wools, and much of the outer layer of skin.

Answer 35

alpha-keratin

Question 36

This enzyme catalyzes the interchange of disulfide bonds until the native conformation is formed.

Answer 36

Protein disulfide isomerase (PDI)

Question 37

This enzyme catalyzes the interconversion of the cis and trans isomers of Pro residue peptide bonds.

Answer 37

Peptide prolyl cis-trans isomerase (PPI)

Question 38

This protein structure is found int he beta conformation and has soft, flexible filaments.

Answer 38

silk fibroin

Question 39

This type of protein is found in connective tissue , such as tendon or cartilage.

Answer 39

collagen