PRRSV

Question 1

WHAT does PRRSV stand for?

Gestation of pig

Answer 1

Porcine Reproductive and Respiratory Syndrome Virus

115 days

Question 2

How important is Porcine Reproductive and Respiratory Syndrome Virus and what does it cause?

Answer 2

most important infectious agent causing reproductive failure in sows and severe pneumonia in piglets.

Question 3

Pathogenesis of PRRS virus

Answer 3

Transmission by inhalation, ingestion, coitus, skin damage and contaminated needles

Arteriviruses replicate in the perinuclear cytoplasm of their host cells.
Replication in mucosal, pulmonary, or regional macrophages- target being alveolar macrophages of pig

Regional lymph nodes and virmaemia (with 12 hrs post-infection)

Systematic distribution to mononuclear cells and tissue macrophages

Clinical disease (age dependent)

Question 4

Clinical sign in sow

Answer 4

Vetrical trans placental transmission means that repro failure: still births, abortion or weak live born

Question 5

Clinical sign in neonate

Answer 5

dyspnea, CNS signs, high mortality

Question 6

Clinical sign in grower

Answer 6

increased mortality, secondary infections, failure to thrive. = economic loss

Often subclinical but if clinical then usually respiratory:
fever, sneezing, hyperpnea, dyspnea, cough, pneumonia, leathargy