Psoriasis Flashcards Preview

Dermatology > Psoriasis > Flashcards

Flashcards in Psoriasis Deck (7)
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1
Q

What is the pathophysiology of psoriasis?

A
  • Acute, intermittent of chronic skin disease
  • multifactoral: genetic, immune and environment
  • Abnormal T cell activity stimulates keratinocyte proliferation
2
Q

What are recognised subtypes of psoriasis?

A
  • Plaque psoriasis (most common)
  • Flexural psoriasis
  • Guttate psoriasis
  • Pustular psoriasis
3
Q

What are the features of plaque psoriasis?

A

*Well demarcated red, scaly patches affecting extensor surfaces, sacrum and scalp

4
Q

What nail features can be seen in psoriasis?

A
  • Pitting

* oncholysis

5
Q

What following factors can exacerbate psoriasis?

A
  • Trauma
  • Alcohol
  • Drugs: lithium, beta blockers, antimalarials, NSAIDs, ACEi
  • Withdrawal of systemic steroids
6
Q

What is the management of chronic plaque psoriasis?

A

1a. Regular emollients help to reduce scale loss and reduce pruritus
1b. Potent topical steroid + vit D analogue OD
2. No improvement after 8 weeks offer vit D analogue BD
3. No improvement after 8-12wks then potent sterid BD
4. Short acting dithranol can be used

Secondary Care:
5. Phototherapy

  1. Immunosuppresants: methotrexate, ciclosporine, acitretin, biological therapy
7
Q

How do vit D analogues work?

A

Reduce cell division and differentiation