PSY280 - 10. Chemical senses Flashcards

(75 cards)

0
Q

chemical senses

A

molecules floating in the air + molecules you put in your
mouth
stimulants incorporated into our body
have to take molecules in to experience perception

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Chemical senses

A

basic purpose of life to take-in some substances & avoid others: which ones are which?
food vs toxins
to identify chemicals, help us identify which molecules are helpful

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

olfaction

A

odorant is an aromatic chemical.

Odor is the olfactory sensation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Odorant

A

produce an odor, ordorant needs to be volatile & hydrophobic - There are some notable exceptions.
volatile - can become airborn
hydrophobic - repellant to water

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Odorant

A

allows odourant to remain separate from medium, doesn’t dissolve in mucus + membrane to reach receptors
more molecules will have an odour, but not true universally
CO - byproduct of methane gas, but odourless - associate it with smell but added so we can detect it

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

the apparatus

A

2 bilateral olfactory bulb - first site of processing, two, ipsilateral
glomerulus (pl. glomeruli): with bulb organize info about odourants
cribriform plate - separates nose from brain
axons of OSN pass through tiny holes
olfactory epithelium - retina of the nose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

the apparatus

A
olfactory mucosa: capture odourants to facilitate interaction with olfactory receptor neurons
olfactory receptor (sensory) neurons: translates it to electrical signals
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

the apparatus

A

olfactory cilia: dendrites of sensory receptors - experience adult neurogenesis - regenerate every 28 days
contain receptors which interact with odourant molecules
turbinates - direct volatile molecules to olfactory epitheluim
nose - primary purpose to filter warm + humidify air before it’s passed on to lungs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

the apparatus

A

pass through cribiform - delicate axons pass through tiny holes to synapse with olfactory bulb
olfactory bulb extension of brain - ipsilaterally organized

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

threshold

A

average, 7-8 molecules bind to one receptor to trigger an action potential & 40 action potentials are required for us to experience of odor*
detection threshold - lowest concentration of odourant that can be detected

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

threshold

A

sensitivity varies based on substance
CO2 low threshold important to detect
acetone has high threshold even though we can easily smell it

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

detecting odors

A

Dogs 30-100,000X more sensitive than people:
1 billion more ORNs, more cortex
humans .1% vs dogs 5% dedicated
not bad in detecting smells, humans can follow 10 m scent track of chocolate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Anosmia

A

total inability to smell, sinus infection/head trauma:
associated with depression
sensitivity declines with age
delicate sense

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Anosmia

A

dependent on smells reaching olfactory - going through small axons
head trauma - can cut axons and may not come back
highly associated with depression: most likely has to do with adult neurogenesis - decreases in limbic system
die out faster than regeneration as we age

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Olfactory receptors

A

analogous to visual pigments except humans have about 350 different types of receptors, not just 4
diff receptors respond to diff odourants - each of them has only 1 receptor type
will respond to range of odourants, but tend to have a preference

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Olfactory receptors

A

1000 genes that code for olfactory receptors, but many are non-functional in humans, most are functional in rats, and dogs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Evolutionary Trade-Off?

A

trichromats vs dichromats
primates are trading olfaction for vision
old world - less olfactory genes, more colour vision
new world - more olfactory genes, less colour vision

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Olfactory receptors

A

Each kind of receptor widely distributed across olfactory epithelium, but synapse on a specific glomeruli pair
glomeruli receive diff type of stimuli: organize info based on odourant in the olfactory bulb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Olfactory receptors

A

can receive all of signals from red and green
Molecular structure does not predict odor experience.
two diff structures can produce same odour

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Ca2+ imaging

A

infuse odourant into fluorescent to easy visualize
CA+ enters cell during depolarization, decreasing concentration of fluorescence - means stronger activation
patterns of activation determines smell
each odourant can activate diff receptor types

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

at the receptors

A

Using Ca2+ imaging can identify odorant recognition profile - pattern of activation across multiple olfactory receptor types
similar structures can produce similar recognition profiles - not necessarily the case

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

in the olfactory bulb

A

Each odorant activates multiple glomeruli, location related to length of carbon chain for the chemical
produce pattern of activation across multiple glomeruli
carbon chain attached, but length varies
shorter chains more posterior/longer chains more anterior
location coding in olfactory bulb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

in the olfactory bulb

A

Chemical structure matters less than the pattern of activity for determining odor
diff forms of same molecule where structure is flipped
stereoisomers smells diff, activation is also diff
similar pattern of activation, similar smell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

higher-order processing

A

O1 & O2 have strong bi-directional connections to
limbic system, including the amygdala
piriform cortex - basic qualities related to odour are processed
orbitofrontal - analyzing odour at higher level, what they indicate - reward or punishment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
higher-order processing
In olfactory bulb, evidence of placing coding (chemotopic map), but in the cortex, activation is more distributed distributed level of activation across puriform cortex - expect odours processed synthetically
25
synthetic or analytic?
Audition is analytic: diff pitches activate diff parts of cochlea & we hear separate pitches Vision is synthetic: 2 diff wavelengths of light combine to produce a singular experience of a diff color analytic - distinct stimuli processed as seperate stimuli synthetic - 1 experience even when contains multiple wavelengths
26
synthetic or analytic?
Olfaction is both, with a tendency toward synthesis: few odours that contain only 1 odourant Analytic abilities vary with practice: depends on familiarity + practice in differentiating
27
synthetic or analytic
odour presented simultaneously can identify 3/5 each odour has separate odourant molecules produces distinct smell of bacon our ability to distinguish bacon because we’ve experienced in diff contexts
28
identifying odors: presence vs. quality
detection/discrimination not identification diff thresholds for each of these identification threshold is 3x more than detection 350 olfactory receptor types to produce hundred thousands of types
29
the mute sense
All languages have only few words exclusively to describe smell inability to name it even when they find it familiar huge gap between odour and language aromatic, redolent, stinky, fragrant, pungent
30
the mute sense
descriptors to odour - we talk about odour itself floral - flowers/fruity - fruit deep disconnection with language not just in english
31
several explanations for disconnect:
resources only sense not integrated through thalamus damage to thalamus associated with language deficits lateralized to right hemisphere, whereas language is in the left
32
several explanations for disconnect:
competition for resources - language + smell need same resources process semantics, and present odour stimulus, changes fmri signal and ppl less likely to recall word later can’t do both at same time but to process non semantic processes - length - don’t get interference
33
olfactory hedonics
Intensity has a complex relationship with liking dimension of odor. breaks down based on hedonic value of odourant inverted u shape pleasant: low - neutral, peak - pleasant, high - unpleasant negative linear unpleasant: low - neutral, high - unpleasant both unpleasant for high intensity
34
olfactory hedonics
tend to like familiar odors, & to think pleasant odors are familiar. familiarity is a top-down contribution more semantic based top-down contributions like applying labels
35
olfactory hedonics
Other top-down contributions, like labels can influence same odour told cheddar cheese/body odour diff hedonics - diff labels: fritos and dog feet, weed and skunks orbitofrontal - tracks reward + punishment
36
innate
``` # of diff olfactory receptors expressed by any 1 person is quite variable + probably corresponds to intensity of smell. high intensity we don’t like regardless ```
37
innate
anosmic to androstenone found either sweet musky or urinous clearly have some genetic component
38
learned
Babies don’t find either sweat or feces unpleasant | learn associations
39
learned
prenatal experience plays a role Mothers who consume distinctive smelling volatiles have newborns who show greater preference for those odors
40
learned
no universally unpleasant odors, but there are cultural preferences hedonics largely dictated by experience which is cultural specific secondary olfactory - in prefrontal cortex because it tracks reward value
41
Odors have an unusually retention curve
non linear diff rates of decrease - steeper, then more stable small decline overall right after, still don’t have a high recognition lost 25% accuracy in 30 seconds what we remember after 30 seconds, close to what we remember after a week, month, year
42
Smell
no better than other sensory cues for recall of specific memories reputation that it’s best cue for recall in terms of accuracy, same as other modalities in terms of emotionality, smell wins in both lab induced + autobiographical - report more memory + greater intensity
43
Proust effect
induce recall for memory from events that happened years ago | unintentional recall of memories from pasts
44
Proust effect
In animals that rely on smell for survival, there are two subdivisions of the olfactory system: main & accessory olfactory bulb main olfactory: responisble for detecting and organizing molecules that interact with epithelium accessory: triggered by vomeronasal organ
45
Proust effect
vomeronasal organ evolved to detect large or aqueous molecules, primarily pheromones detect those that can’t be detected by main olfactory pheromones - trigger response in other species signal - danger, reproductive equivocal evidence that we respond
46
McClintock effect
menstrual synchrony | pheromones explanation
47
McClintock effect
Underarm sweat from different times in the cycle caused menstrual cycles to either lengthen or shorten random cycles when viewed through small window can give appearance of synchrony that’s untrue
48
pheromones in humans: the evidence
exotic dancers: make more money when ovulating men smelling t-shirts: men tshirts worn by females ovulating on birth control make more money
49
pheromones in humans: the evidence
chemicals in women’s tears decrease sexual arousal in men significant in sexual attraction, less attracted to female faces breastfeeding women increases sexual arousal in other women especially with a sexual partner
50
Gustation
gatekeeper between taste quality + substance’s effect: sweet= caloric bitter=poison salt=sodium sour=acid discern which chemicals to ingest + spit out
51
Gustation
more deliberate - more important hedonics more specific four basic qualities + maybe 5 children avoid bitter flavours - desirableness is learned
52
the apparatus
papillae (bumps) filiform - most of bumps, no taste, texture especially in trough - not directly involved in taste fungiform - mushroom-shaped, edges of tongue especially tip foliate - folded, sides & back of tongue circumvallate - flat mound surrounded by trench
53
the apparatus
texture allow us to detect texture + spreads molecules over tongue buds - globular clusters of taste cells
54
the apparatus
taste cells - signals are conveyed through brain each taste cells have microvilli that project through taste pore taste receptors specialized for quality - 1 for each - can appear on any type of papillae diff receptors on a single taste cell
55
taste receptors
Salty (Na+) & sour (H+) ions enter the cell through ion channels, directly increasing the potential inside the cell to trigger depolarization.
56
taste receptors
salty + sour bundled - both positive ions - change drives membrane potential - triggers depolarization encourages Ca to enter cell + triggers release of neurotransmitters saliva breaks it down to ions
57
taste receptors
Sweet, bitter & umami molecules act through second messenger: activate G-protein triggers enzyme cascade, Ca2+ released intracellularly, triggers neurotransmitter release bind with receptors activating the G protein which triggers an enzyme cascade - intracalcium stores which in turn triggers release
58
taste receptors
chemotopic map (doesn’t exist) detection threshold is similar across bitter - back of throat highly sensitive
59
umami: is it or isn’t it?
quality evoked by monosodium glutamate & is described as meaty, brothy, & savory. idea is an advertising campaign that insisted it signaled consumption of protein but peanut butter is high in protein, yet it doesn’t have umami taste survival advantage of protein, but some people don’t like protein
60
umami: is it or isn’t it?
associated with sweet receptors in the gut • safe for consumption umami receptors unique combo of 3 + 2 - take off of sweet
61
umami: is it or isn’t it?
receptors in a way they aren’t organized break down of protein into glutamate associate msg with reward - only works if you swallow it have to consume protein to develop associations no evidence that msg is bad for you
62
higher-order processing
signals from the taste buds transmitted via 3 cranial nerves: nucleus of the solitary tract ! thalamus !insula & frontal operculum (T1) !orbitofrontal cortex innervate tongue and throat converge in brain stem thalamus to insula + frontal operculum - primary cortex for taste perception some end up in orbitofrontal cortex - reward + punishment - how taste preference is formed
63
distributed or specificity coding?
Reports from subjective experience in humans parallels these results. distributed coding sodium chloride diff activation with potassium chloride +
64
distributed or specificity coding?
amonium chloride pair foot shock with KCL enough, so classical conditioning takes place transfers to ammonium but not sodium chloride
65
distributed or specificity coding?
Sucrose, NaCl, HCl & QHCl are compounds that com the closest to having only one of the four basic tastes. Each tends to activates specific neurons in the chorda tympani. shows some specificity
66
distributed or specificity coding?
But! Taste cells can have more than one type of taste receptor, & the nerve fibers that innervate them can synapse with more than one taste cell! taste cells have more than one taste receptor nerve fibers specificity - how it’s organized is a mystery don’t know how we identify taste perception distributed - most valid way
67
genetic variation in taste experience
``` PROP & PTC: some people taste it (tasters), some people don’t (nontasters) 1/3 taste nothing 2/3 bitter taste prop = taster PTC related compound - safer ```
68
Tasters
tend to be more finicky eaters. Supertasters have more fungiform papillae, and experience the most intense taste sensations. more sensitive to bitter tastes fewer alcoholics because of sensitivity linked to a specific gene supertasters more intense taste perception some ppl report more or less intense taste - most intense oral burnings and acids - generally avoid feel fats + thickeners more
69
Flavor
combination of basic tastes, retronasal olfaction, & tactile sensations tactile critical component to our experience preference often around texture
70
Flavor
When you pinch your nose, the experience of flavor is significantly diminished. pinch nose reduces flavour decreases identification
71
Flavor
Flavor is localized to the mouth, except for volatiles that activate c-fibers in the nasal cavity. localize to mouth - where you feel + put the food volatiles that activate c fibers can feel like burning in your nose
72
Flavor
Responses from taste & smell are first combined in the orbitofrontal cortex. vison, taste, olfaction, touch converge here place where flavour lives directly correlates with hedonic experience
73
Activity in the OFC indicates hedonic qualities of flavor
pleasure varies according to OFC activity first got it - excited as they got more and more, monkeys no longer wanted it similar pattern in OFC activation tracking reward + punishment + changes in rewarding value of stimulus
74
Sensory-specific satiety
refers to the fact that we can be satiated for one flavor (broccoli), but still have room for apple pie. can be satiated for one flavour but have room for another flavour can get nutrients from diverse flavours