Psych Flashcards

(166 cards)

1
Q

EUPD description (3)

A

Problems in the functioning of aspects of self i.e. self-worth and direction

Intense interpersonal relationships that alternate between idealisation and devaluation

Associated with a history of recurrent self-harm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Histrionic PD description

A

Need to have attention and acting in a dramatic and narcissistic way to achieve this

Inappropriate sexual seductiveness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Paranoid PD description

A

Hypersensitivity and unforgiving if insulted

Question loyalty of those around them and are reluctant to confide in others

Anti-social

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Schizoid PD description

A

Anti-social, aloof, indifferent and not complying to social norms

Lack of interest in sexual interactions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Schizotypal PD description

A

History of ‘magical thinking’ / odd beliefs and ideas of reference

Lack of close friends other than family members

  • The ideas of reference are not firm enough to meet the criteria for delusional disorder or schizophrenia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Narcissistic PD

A

Grandiose sense of self importance

Preoccupation with fantasies of unlimited success and power

Lack of empathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Obsessive-compulsive / Anakastic PD

A

Unhelpful perfectionism - occupied with details, rules, lists

Rigid with respect to morals, ethics and values that everyone should follow

Unwilling to pass on tasks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Avoidant/anxious PD

A

Preoccupied with ideas that they are being criticised or rejected in social situations and therefore avoid interpersonal contact

Certainty of being liked is needed before becoming involved with people

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Dependent PD

A

Difficulty making everyday decisions without excessive reassurance from others

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Anti-social PD

A

Failure to conform to social norms
Repeatedly performing acts that are grounds for arrest
More common in men
Lack of remorse
Aggressiveness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Psychological therapy used for EUPD

A

Dialectical behaviour therapy (DBT)

medication should not be used unless comorbidities exist e.g. depression or psychosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Factors favouring delirium over dementia

A

Acute onset
Impairment of consciousness
Fluctuation of symptoms: worse at nights, periods of normality
Abnormal perception (e.g. illusions and hallucinations)
Agitation, fear
Delusions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Monoamine Oxidase Inhibitor metabolise which neurotransmitters

A

serotonin and noradrenaline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

2 examples of MAOIs drugs
- ine

A

Phenelzine
Tranylcypromine
Selegiline
Isocarboxazid
Rasagiline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Adverse effect of non-selective MAOI drugs

A

‘Cheese effect’:
Hypertensive reactions with tyramine-rich foods e.g. cheese, pickled herring, Bovril, OXO, marmite, broad beans

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Prophylactic mood stabilisation in bipolar disorder 1st & 2nd line

A

1st line: Lithium (teratogenic)
2nd line: Sodium valproate (teratogenic)
3rd line: Olanzapine
Rapid cycling bipolar: Carbamazepine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Difference between hypomania and mania

A

Mania: severe functional impairment or PSYCHOTIC symptoms (e.g. delusions of grandeur) for 7 days or more
- Type 1

Hypomania: decreased or increased function for 4 days or more
- Type 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Side effects of Lithium - name 5

A

Nausea/vomiting/diarrhoea
Hypothyroidism / Weight gain
Fine tremor
Polyuria and polydipsia secondary to nephrogenic DI (lithium = nephrotoxic)

Other:
Hyperparathyroidism and resultant hypercalcaemia (stones, bones, moans, groans)
Idiopathic intracranial hypertension
Leucocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Lithium monitoring

A

Lithium levels:
taken 12 hours post-dose
After a dose change or after starting: weekly until levels are stable
Normally checked every 3 months

Thyroid and renal function (U&Es, eGRF) should be checked every 6 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

3 reasons lithium toxicity may be precipitated

A

Dehydration
Renal failure
Drugs: diuretics, ACE inhibitors, NSAIDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Features of lithium toxicity - name 4

A

Coarse tremor (fine tremor seen in therapeutic)
Hyperreflexia
Acute confusion
Polyuria
Seizure
Coma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Management of assisted alcohol withdrawal

A

1st line: oral long acting benzo e.g. Lorazepam or Chlordiazepoxide

IV if symptoms persist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Features of alcohol withdrawal (timed stages)

A

6-12 hours: symptoms
36 hours: seizures
48-72 hours: delirium tremens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What is given during alcohol detoxification to replenish low B1 stores in delirium tremens

A

IV Pabrinex (thiamine, riboflavin etc.)

oral thiamine is used to replenish low B1 stores when not in DE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Risk factors for delirium
PINCHME Pain Infection (think UTI) Nutrition Constipation Hydration Medication Environment Hypoxia (type 1 resp failure i.e. low O2 with normal CO2)
26
Causes of serotonin syndrome (2)
1. Antidepressants e.g. MAOIs + SSRIs e.g. rasagiline + Citalopram, or SSRI-drug interactions e.g. St John’s wort / Tramadol 2. Illicit substances e.g. Ecstasy + Amphetamines
27
3 features of serotonin syndrome (triad)
*think: excess 5-HT to neuromuscular and central synapses (brain + spinal cord)* **Neuromuscular excitation:** Hyperreflexia, Myoclonus, Rigidity **Autonomic nervous system excitation:** Hyperthermia, Sweating 😓 **Altered mental state:** Confusion
28
Favouring features for neuroleptic malignant syndrome compared with serotonin syndrome
Caused by antipsychotics Slower onset (days to weeks vs 24h) Hyporeflexia, normal pupils
29
Neuroleptic malignant syndrome investigation results
Raised creatine kinase (due to muscle rigidity) - rhabdomyolysis Raised white cell count (leukocytosis) Acute renal failure = abnormal U&Es Deranged LFTs Metabolic acidosis - low pH, low HCO3
30
Neuroleptic malignant syndrome tetrad
*think: neurotransmitter overload:* 1. Autonomic instability - hypertension, tachycardia, tachypnoea 2. Altered mental status - delirium with confusion 3. Hyperthermia (pyrexia) *think: dopamine overload i.e. Parkinsonism rigidity:* 4. Muscle rigidity
31
Definition of severe depression
**triad** *(low mood for at least 2 weeks, anhedonia, anergia)* **PLUS** most other symptoms e.g. weight change, sleep change, psychomotor, worthlessness, inability to think, suicidal ideation - **all of which markedly interfere with functioning** **PHQ-9 > 16**
31
3 core symptoms of depression
Low mood for at least **2 weeks** Anhedonia Anergia
32
ICD-10 criteria for delirium (5)
1. Impairment of consciousness and attention 2. Global disturbance in cognition 3. Psychomotor disturbance 4. Disturbance of sleep-wake cycle 5. Emotional disturbances
33
Name 4 medical problems associated with Down’s syndrome
Heart defects (ToF, AV/V/A septal defects) Hearing loss Visual disturbance (cataracts, strabismus) GI problems (oesoph/duodenal atresia, Hirschsprung’s) Hypothyroidism Haematological malignancies (AML, ALL) Alzheimer’s risk increase
34
Describe 4 physical appearance features in Down’s syndrome
Face: Upslanting palpebral fissures Epicanthic folds Brushfield spots in iris Protruding tongue Small low set ears Round/flat face Flat occiput Single palmar crease
35
NICE first line for mild depression
Watch and wait (review in 2 weeks) and consider referral to IAPT for **low intensity** psychological interventions
36
NICE first line for severe depression
Combination of individual CBT + an antidepressant
37
First line antidepressant for less severe depression
SSRI
38
What kind of antidepressant is amitriptyline
Tricyclic antidepressant *NICE recommends avoiding TCAs in history or risk of overdose due to toxicity*
39
What kind of antidepressant is duloxetine
SNRI
40
What kind of antidepressant is isocarboxazid
MAOI
41
GAD definition
Syndrome of **ongoing, uncontrollable, widespread worry** about **many events** that the patient **recognises as excessive** - must be present on most days for at least **6 months**
42
Agoraphobia definition
Fear of **public spaces** or fear of entering a public space from which immediate escape would be difficult in the event of a panic attack
43
First and second line drug for GAD
1. SSRI e.g. sertraline 2. another SSRI or an SNRI e.g. duloxetine and venlafaxine
44
Examples of stimulant drugs
Cocaine Meth MDMA Khat Nicotine
45
4 main dopaminergic pathways
Mesolimbic Mesocortical Nigrostriatal Tuberohypophyseal
46
4 common indications for the prescription of a benzodiazepine
Alcohol withdrawal Seizures Severe anxiety Severe insomnia *Benzos should not be used for more than 2-4 weeks due to addiction / side effects (drowsiness)*
47
4 extrapyramidal side effects of **typical antipsychotics**
Parkinsonism Acute dystonia - sustained **muscle contraction** such as torticollis or oculogyric crisis Akathisia (severe **restlessness**) Tardive dyskinisea (**chewing and pouting of jaw or excessive blinking**)
48
How is acute dystonia secondary to antipsychotics managed
Procyclidine *anti-cholinergic which corrects cholinergic neurotransmission*
49
what 2 complications can antipsychotics cause in the elderly
Stroke VTE
50
Non-EPSE side effects of typical antipsychotics
Antimuscarinic - dry mouth, blurred vision, urinary retention, constipation Sedation Dyslipidaemia/Weight gain Hyperprolactinaemia - may result in galactorrhoea Dysglycaemia/diabetes Mellitus Prolonged QT interval (particularly haloperidol)
51
Adverse effects of atypical antipsychotics
Weight gain Hyperprolactinaemia + Clozapine is associated with agranulocytosis
52
Examples of atypical antipsychotics
Clozapine Olanzapine Risperidone Quetiapine Amisulpride Aripiprazole
53
Atypical antipsychotic that increases risk of dyslipidemia and obesity
Olanzapine
54
Atypical antipsychotic with good side effect profile
Aripiprazole
55
Why is FBC monitoring essential during clozapine treatment
Significant risk of agranulocytosis
56
When is clozapine indicated in schizophrenia
Sequential use of two or more antipsychotic drugs (one of which should be a second generation anti-psychotic drug) each for at least 6-8 weeks
57
What activity can cause a rise in clozapine blood levels
Smoking
58
Adverse effects of clozapine (5)
Agranulocytosis, neutropaenia Reduced seizure threshold Constipation Myocarditis Hypersalivation
59
Management of depressive episode in bipolar disorder
Fluoxetine + atypical antipsychotic e.g. olanzapine Talking therapies
60
Management of manic episode in bipolar disorder
Consider stopping antidepressant (SSRIs and TCAs especially venlafaxine increase risk of 'switch') Atypical antipsychotic therapy e.g. olanzapine
61
Midazolam
RAPID acting benzo Indications: status epilepticus
62
ICD-10 criteria for agoraphobia
- fear and avoidance of 2 of: crowds, public spaces, travelling alone, travelling away from home - symptoms of anxiety in feared situation with autonomic arousal - significant emotional distress due to avoidance or anxiety symptoms - recognised as excessive or unreasonable - symptoms restricted to feared situation
63
Panic disorder definition
Recurrent, episodic, severe panic attacks which are unpredictable and not restricted to any particular situation or circumstance Not associated with marked exertion or with exposure to dangerous or life-threatening situations
64
ICD-10 criteria of panic disorder (5)
- discrete episodes of intense fear or discomfort - starts abruptly - reaches a crescendo within a few minutes and lasts at least some minutes - at least 1 symptom of autonomic arousal - other symptoms of anxiety
65
Schizophrenia Schneider's first rank symptoms (4)
auditory hallucinations delusional perceptions thought disorders passivity phenomena
66
Auditory hallucinations in schizophrenia (3)
thought echo two or more voices discussing the patient in the third person voices commenting on the patient's behaviour
67
Thought disorders in schizophrenia (3)
thought insertion thought withdrawal thought broadcasting
68
Passivity phenomena seen in schizophrenia definition
bodily sensations being controlled by external influence
69
Delusional perceptions in schizophrenia definition
two stage process: first a normal object is perceived secondly there is a sudden intense delusional insight into the objects meaning for the patient e.g. 'The traffic light is green therefore I am the King' *this can include persecutory delusions*
70
Name 4 negative symptoms of schizophrenia
incongruity/blunting of affect anhedonia (inability to derive pleasure) alogia (poverty of speech) avolition (poor motivation) social withdrawal
71
Schizophrenia prognostic indicators
strong family history gradual onset pre-morbid low IQ prodromal phase of social withdrawal lack of obvious precipitant
72
Strongest risk factor for developing a psychotic disorder
Family history
73
Risk factors associated with an increased risk of future completed suicide after an attempted suicide (5)
efforts to avoid discovery planning leaving a written note final acts such as sorting out finances violent method
74
Suicide risk factors
**static**: male sex history of deliberate self-harm history of mental illness depression schizophrenia (10%) history of chronic disease advancing age **dynamic**: alcohol or drug misuse unemployment or social isolation/living alone financial problems being unmarried, divorced or widowed
75
Flumazenil
reverses the sedative effects of benzodiazepines (particularly in benzodiazepine overdose)
76
Indication for the use of EMDR in PTSD
recommended in patients who have presented **between 1 and 3 months** after a **non-combat related** trauma who specifically **prefer EMDR > trauma-focussed CBT**
77
Indication for the use of trauma-focused CBT in PTSD
1st line for patients
78
1st line medical management of PTSD (2)
**SSRIs** e.g. sertraline or **venlafaxine** (SNRI)
79
4 types of thought disorganisation seen in psychosis
alogia e.g. … *(poverty of speech)* tangentiality e.g. ‘How was your week?’ ‘The sky is blue’ clanging e.g. Where are the keys knees freeze breeze? word salad e.g. soggy blankets and red tomatoes
80
5 conditions where psychosis is a symptom
Schizophrenia (most common) Depression (psychotic depression seen in elderly patients) Bipolar disorder Parkinson's disease Corticosteroid induced Illicit drugs e.g. cannabis
81
Knight's move thinking
phenomenon where a patient’s thoughts move from one topic to another **differential from flight of ideas**: knight’s move has no logical connection between them
82
Flight of ideas
increased rate of thought with at least some logical links between the frequent changes of topics that a patient is talking about *commonly a feature of mania/hypomania*
83
Circumstantiality
patient gives an excessive amount of detail that is irrelevant to the question but there is a logical progression of thought + normal rate
84
Perseveration
repetition of a certain word/phrase/thought
85
Features of opioid misuse
rhinorrhoea needle track marks pinpoint pupils drowsiness watering eyes yawning
86
emergency management of opioid overdose
IV or IM naloxone
87
1st line treatment for opioid detoxification
methadone or buprenorphine
88
lithium in pregnancy
**teratogenic** *risk of **Ebstein's anomaly** (congenital heart defect characterised by enlarged right atrium, shrunken right ventricle, pansystolic murmur by defective tricuspid valve)*
89
Clomipramine
**tricyclic antidepressant** used 2nd line in **OCD**
90
4 features of a capacity assessment
WURC The ability to… **weigh-up** **understand** **retain** **communicate** …the decision made
91
How does a person need to communicate their decision for a capacity assessment
A person can communicate their decision verbally or by other means such as in writing or via sign language, **the assessor must take into account the patients’ primary communication method**
92
Egodystonic vs egosyntonic in OCD thoughts
Obsessive thoughts are usually **egodystonic** (very **different** to the patient’s normal beliefs and values) rather than egosyntonic (in keeping with ones beliefs and values)
93
Cognitive function test used in primary care settings
Six Item Cognitive Impairment Test (6-CIT)
94
Medications associated with delirium
PROF Propranolol Ranitidine (H2 blocker) Chlorphenamine (H1 blocker) Oxybutynin - causes constipation (PINCH ME) Furosemide (diuretic)
95
Blood test monitoring clozapine
first 18 weeks: minimum of 1 blood test per week until 1 year: fortnightly after 1 year: monthly (as long as there are no abnormalities)
96
Confusion screen (4)
**Infection screen** Chest X-ray C-Reactive Protein Full Blood Count, B12/folate, TFTs, glucose, calcium Urinalysis
97
**Depression** over Dementia features
short history, rapid onset biological symptoms e.g. weight loss, sleep disturbance patient worried about poor memory reluctant to take tests, disappointed with results mini-mental test score: variable **global memory loss** (dementia characteristically causes recent memory loss)
98
GAD risk factors (4)
Aged 35-54 Being divorced or seperated Being a lone parent Living alone
99
How long should a patient continue with treatment once they have reached remission with antidepressant therapy
6 months (to reduce the risk of relapse)
100
Over what period of time should SSRIs be reduced when stopping them
4 weeks
101
Section 5 (4)
Holding power for **nurses** for up to **6 hours**
102
Section 5 (2)
Holding power for **doctors** for up to **72 hours**
103
key differential when elderly patient experiences drowsiness, confusion, or convulsions while taking an SSRI
Hyponatraemia
104
Disulfiram
Deterrent drug which increases serum acetaldehyde if alcohol is consumed which causes diaphoresis, palpitations, facial flushing, nausea etc. *not an anti-craving drug - used for alcohol abstinence*
105
Naltrexone use in alcohol abuse recovery
Naltrexone blocks opioids from releasing endorphins (associations of alcohol with endorphin rush are diminished) = undermines the reinforcement/reward system with drinking alcohol
106
3 drugs used for alcohol addiction rehabilitation
Naltrexone Disulfiram Acamprosate
107
Normal pressure hydrocephalus
Reversible cause of dementia thought to be secondary to reduced CSF absorption at the arachnoid villi *these changes may be secondary to head injury, sub arachnoid, meningitis*
108
Normal hydrocephalus features triad
Urinary incontinence Dementia and bradyphrenia Gait abnormality
109
Neuroimaging of normal pressure hydrocephalus
Ventriculomegaly in the absence of sulcal enlargement
110
Management normal pressure hydrocephalus
Ventriculoperitoneal shunting
111
Medications that can trigger anxiety (5)
Salbutamol Theophylline Corticosteroids Antidepressants Caffeine
112
Alternative causes of anxiety disorders
Hypothyroidism - TFTs Cardiac disease - ECG Medication induced anxiety Anaemia (palpitations + fatigue) - FBC Phaeochromocytoma - 24 hour urinary metanephrines
113
Management of serotonin syndrome
IV fluids + **Benzodiazepines** More severe cases: serotonin antagonists i.e. cyproheptadine and chlorpromazine
114
1st line management step after someone presents with depression in a primary care setting for the first time
PHQ-9 questionnaire
115
Acamprosate mechanism of action
Reduces alcohol cravings by increasing GABA transmission
116
Indication for the use of mertazapine as an antidepressant
the 2 side effects of mirtazapine, sedation and an increased appetite, can be beneficial in older people that are suffering from insomnia and poor appetite
117
what is the 1 absolute contradiction for ECT
Raised intracranial pressure
118
Causes of drug induced psychosis
Illicit substances Alcohol Anti-malarial Bromocriptine Levodopa Steroids
119
Edwards and Gross criteria for alcohol dependence
- Narrowing of repertoire - Salience of drink-seeking behaviour - Increased tolerance to alcohol - Repeated withdrawal symptoms - Relief or avoidance of withdrawal symptoms by further drinking - Subjective awareness of compulsion to drink - Reinstatement after abstinence
120
Schizoaffective disorder
Schizophrenia along with another disorder e.g. depression or bipolar
121
What age does autism normally present by
3 years old
122
Features of autism
1. Impaired social communication and interaction 2. Repetitive behaviours, interests, and activities Often associated with intellectual impairment or language impairment ASD has a co-occurrence of 35%
123
3 management options in autism
Early educational and behavioural interventions e.g. applied behavioural analysis SSRIs for anxiety symptoms Family support and counselling
124
Risk factors for OCD
Family history Age: peak onset 10-20 years Pregnancy/post natal period History of abuse, bullying, neglect
125
Severe OCD features
> 3 hours a day on their obsessions/compulsions Severe interference/distress Very little control/resistance
126
Mild functional impairment OCD management
1st: low-intensity CBT including exposure response prevention 2nd: SSRI or more intensive CBT with ERP
127
Moderate functional impairment OCD management
1st: Intensive CBT with ERP +/- SSRI for at least 12 weeks 2nd: Different SSRI or Clomipramine (1st if the person prefers it, has had a good previous response, or if SSRI is C/I)
128
Severe functional impairment OCD management
**Refer to the secondary care mental health team for assessment** and whilst waiting offer **SSRI and CBT with ERP (or clomipramine as alternative)**
129
SSRI for body dysmorphia
Fluoxetine
130
OCD SSRI dose vs depression
Higher dose and longer duration of treatment before an initial response (at least 12 weeks)
131
Somatatisation disorder definition
Multiple physical **symptoms** present for at least 2 years Patient refuses to accept reassurance or negative test results
132
Illness anxiety disorder (hypochondriasis)
Persistence belief in the presence of an underlying serious **disease** e.g. cancer Patient refuses to accept reassurance of negative test results
133
Conversion disorder
Psychological stress ***converted*** to loss of **motor or sensory** function Doesn’t consciously feign the symptoms (factitious) or seek material gain (malingering) La belle indifference = indifferent to their apparent disorder
134
Factitious disorder
Also known as Münchausen’s syndrome Intentional production of physical or psychological symptoms
135
Malingering disorder definition
Fraudulent simulation or exaggeration of symptoms with the intention of financial or other gain
136
Concordance rate for schizophrenia in monozygotic twins
50%
137
Mental Health Act: Section 2
Admission for assessment for up to **28 days** Not renewable 2 doctors (usually 1 consultant psychiatrist) + AMHP Treatment can be given against a patient’s wishes
138
Mental Health Act: Section 3
Admission for treatment for up to 6 months Renewable 2 doctors + AMHP (all must have seen patient within past 24 hours) Treatment can be given against a patient’s wishes
139
How long can a section 136 be used for
24 hours (whilst a MHA assessment is arranged)
140
What should be offered to all schizophrenia patients after medication
Cognitive behavioural therapy
141
Differential diagnoses in depression
Bipolar disorder psychotic disorders premenstrual syndrome substance misuse Anaemia Hypothyroidism
142
3 screening tools for depression
PHQ-9 HADS BDI-II
143
What should be co-prescribed with an SSRI if they are already taking an NSAID
PPI
144
Patient under 25 time until review after initiating SSRIs
1 week
145
Acute stress disorder definition
Acute stress reaction that occurs in the first 4 weeks after a person has been exposed to a traumatic event ***(PTSD is diagnosed after 4 weeks)***
146
1st line for acute stress reaction
1st line: Trauma focused CBT *Benzodiazepines can sometimes be used for acute symptoms e.g. sleep disturbance - but should be used with caution due to addictive potential*
147
4 antipsychotics used in a manic episode
Haloperidol Olanzapine Quetiapine Risperidone
148
2 typical antipsychotics
Chlorpromazine Haloperidol
149
3 features of PTSD
Re-experiencing e.g. flashbacks, nightmares Avoidance e.g. avoiding people or situations Hyperarousal e.g. hyper vigilance, sleep problems
150
Most effective antipsychotic for dealing with negative symptoms
Clozapine
151
Catatonia definition
Stopping of voluntary movement or staying in an unusual position arising from disturbed mental state
152
Most likely SSRI to cause QT prolongation and torsades de points
Citalopram
153
Most useful SSRI post-myocardial infarction
Sertraline
154
SSRI discontinuation symptoms
Increased mood change restlessness Difficulty sleeping Sweating GI symptoms: pain, cramping, diarrhoea Dizziness electric shock sensations Anxiety
155
Use of SSRIs in pregnancy (3)
1st trimester: small risk congenital heart defects 3rd trimester: small risk pulmonary hypertension of new born **Paroxetine** increases risk of congenital malformations (particularly in 1st)
156
SSRI drug-drug interactions
NSAIDs (co-prescribe PPI) Warfarin/Heparin (prescribe mirtazapine instead) Aspirin Triptans (increased risk of SS) MAOIs (increased risk of SS)
157
Recommended monitoring before initiating treatment of SNRI
Blood pressure
158
Signs of cocaine use
Dilated pupils Hyperreflexia
159
Chronic insomnia definition
Difficulty with falling or staying asleep at least 3 nights per week for at least 3 months
160
TCA side effect profile
Histamine receptors: drowsiness Muscarinic receptors: dry mouth, blurred vision, constipation, urinary retention/overflow incontinence
161
Flight of ideas vs knights move thinking
Flight of ideas = discernible links, seen in **bipolar** Knight’s move = no discernible links, seen in **schizophrenia**
162
Where would a patient with hypomania be referred to from primary care
Community mental health team
163
When might dose adjustment of clozapine be necessary
If smoking is started (increase) or stopped (reduce)
164
Charles-Bonnet syndrome
Persistent complex hallucinations occurring in clear consciousness with a background of visual impairment (age related macular degeneration is the most common) Patients usually have insight that the hallucinations are not real
165
anorexia bloods
most things low G's and C's raised: growth hormone, glucose, salivary glands, cortisol, cholesterol, carotinaemia