Psych drugs (GOOD REV!) Flashcards by Stephanie Escobar

List the 6 typical anti-psychotics

+common suffix

Haloperidol
Pimozide
Trifluoperazine
Fluphenazine
Thioridazine
Chlorpromazine
(azine/azide)

(Haloed pimps & trifling thieves flew by cheating)

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increase cAMp

block D2 receptor

typical anti-psychotics

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High potency typical antipsychotics

Haloperidol
Trifluoperazine
Fluphenazine

(trifling Halos flew High)

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Low potency typical antipsychotics

Chlorpromazine, Thioridazine

cheating theives are low

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List 1 atypical antipsychotic and the other’s 2 common suffix

Aripiprazole

(+apine)(+Peridone/ idone)

asenapine, clozapine, quetipine,

iloperidone, paliperidone, risperidone, lurasidone, ziprasidone

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serotonin (2A) and dopamine (D2) antagonist

Atypical antipsychotics

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which atypical anti-psychotic is a partial D2 agonist

Aripiprazole

Ari is a pipsqueak and an atypical pop-star

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causes agranulocytosis and seizures

Clozapine; atypical

watch clozapine closely

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causes hyperprolactenemia (galactorrhea, amenorrhea, man boobs/ gynecomastia)

Risperidone; atypical

makes me think of the ice-cream a raspado. ice-cream is milky

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causes metabolic syndrome

weight gain, dyslipidemia, diabetes

Clozapine
Olanzapine
Risperidone
Quetiapine

(put a CORQ in it)

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Antipsychotics (2)

causes a prolonged QT interval

Ziprasidone (less EPS)

Risperidone (more EPS)

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For treatment resistant schizophrenia &

schizophrenia associated with Suicidality

Clozapine

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Clozapine can cause:
Metabolic syndrome
agranulocytosis

and what else (2)

Seizures

Myocarditis (angina/dyspnea)

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Antipsychotics (2)
Causes sedation, orthostatic hypotension, &
anticholinergic side effects (dry mouth, dilated pupils, tachycardia, constipation)

Chlorpromazine, Thioridazine

1st gen low potency

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Can cause sudden onset sustained muscle contractions, Dystonia. (3)

Haloperidol
Trifluoperazine
Fluphenazine
(typical antipsychotics high potency)

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Can cause Tremor, Rigidity, Blunted affect, and Bradykinesia

Haloperidol
Trifluoperazine
Fluphenazine
(typical antipsychotics high potency)

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Can cause subjective restlessness with inability to sit still (Akathisia)

Haloperidol
Trifluoperazine
Fluphenazine
(typical antipsychotics high potency)

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Can cause involuntary tics or choreoathetoid movements after chronic use

Haloperidol
Trifluoperazine
Fluphenazine
(typical antipsychotics high potency)

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Fever, Rigidity with Hyporeflexia, mental status change, diaphoresis, Autonomic Instability
Recent use of Dopamine Antagonist

Neuroleptic malignant syndrome

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Schizophrenia: excess dopamine in this pathway

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Mesolimbic

Fever, Clonus with Hyper-reflexia, mental status change, Hypertension, tachycardia, diaphoresis
use of SSRI, MOA-I, Dextromethorphan (cough syrup)

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Serotonin Syndrome

Drug-induced parkinsonism is caused by dopamine (D2) receptor blockade in the ____ pathway.

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naigrostriatal

Drug-induced parkinsonism can be caused by (4)

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1st gen Antipsychotics

Antiemetics/gastric motility agents
(metoclopromide, Odansetron/ prochlorepezine)

Mood stabilizers
(Valproate, Lithium)

MPTP dmg to Substantia Nigra

Mood stabilizer for Bipolar

Manic & Depressive features

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Lithium

Mood stabilizer for Bipolar | Manic features only

Valproate, Carbamazepine

``` Mood stabilizer for Bipolar Depressive features (only) ```

Lamotrigene

``` Mood stabilizer with following AE: Nephrogenic Diabetes Insipidus Tremor Hypothyroidism Teratogen (Ebstein's Anomaly) ```

Lithium

Mood stabilizer with following AE: Hepatotoxicity Teratogen (neural tube defects)

Valproate

Mood stabilizer with following AE: Aplastic Anemia SIADH Teratogen (neural tube defects)

Carbamezapine

Mood stabilizer with following AE: Benign Rash Steven Johnson Syndrome

Lamotrigene

Mirtazepine mechanism of action

alpha 2 anTagonist *causes weight gain & sedation. Good for Elderly

Which antidepressants is lethal in overdose

TCAs

TCA overdose treated with

Sodium Bicarbonate (IV)

Monoamine Oxidase Inhibitor mechanism of action

IRREVERSIBLY inhibits MAO A/B to stop the inactivation of NE, 5HT, Dopamine & Tyramine to increase their availability in the synaptic cleft.

Enuresis treated with

Desmopressin (1st line) | Imipramine (TCA)

Chronic pain/ Neuropathic pain treated with (2)

SNRI | TCAs

The only ((mood stabilizer)) shown to decrease suicidality

Lithium

2 mood stabilizers/ anticonvulsants that can cause Stevens Johnson Syndrome

Carbamazepine | Lamotrigine

Medication helps with impulse control, but causes cognitive slowing and kidney stones

Topiramate

a weak, non-competitive antagonist of the NMDA receptor, which increases dopamine release and prevents dopamine re-uptake. Used for drug induced Parkinson's

Amantadine

A cholinesterase inhibitor used to reverse the toxic CNS effects caused by anticholinergic drugs.

Physostigmine

SSRI with anticholinergic SE & weight gain

Paroxetine

3 side effects of Trazadone

Sedation Priapism Orthostatic hypotension

Which drugs go HAM | anti- Histamine, Alpha1, Muscarinic

TCA 1st gen Low pot. antipsychotics Clozapine, Olanzapine, Risperidone, Quetiapine

SSRI with the shortest half-life

Paroxetine (2 weeks or less)

Suvorexant is an ____ inhibitor

orexin | insomnia

What is the Black Box warning for antipsychotics?

Increased Mortality in pts w/ Dementia | still used, but 2nd gen like Quetiapine

Competitive inhibition of histamine at H2 receptors of the gastric parietal cells, which inhibits gastric acid secretion

Famotidine (GERD) *watch for delirium in elderly

Psych drugs (GOOD REV!) Flashcards

(48 cards)