Psych Meds Flashcards
(41 cards)
1
Q
Amitriptyline
A
- TCA
- Oral, > 2 wks to take effect
- Non-specific blockers of monoamine reuptake (NE and 5-HT)
- Highly soluble, long half life
2
Q
Amoxapine
A
- TCA
- Oral, > 2 wks to take effect
- Non-specific blockers of monoamine reuptake (NE and 5-HT)
- Highly soluble, long half life
3
Q
Imipramine
A
- TCA
- Oral, > 2 wks to take effect
- Non-specific blockers of monoamine reuptake (NE and 5-HT)
- Highly soluble, long half life
4
Q
Nortriptyline
A
- TCA
- Oral, > 2 wks to take effect
- Non-specific blockers of monoamine reuptake (NE and 5-HT)
- Highly soluble, long half life
- Blurry vision, dry mouth, anuria, constipation, tachycardia, orthostatic hypotension, sedation, weight gain, sexual dysfunction, seizures, delirium in elderly, mania in bipolar
5
Q
Citalopram
A
- SSRI
- Oral, effects > 2 wks
- Selective for 5-HT reuptake
- Long 1/2 life
- SAFER THAN TCAs early: nausea, anxiety, insomnia. late: anorexia, sexual dysfunction, induction of mania in bipolar
6
Q
Escitalopram
A
- SSRI
- Oral, effects > 2 wks
- Selective for 5-HT reuptake
- Long 1/2 life
- SAFER THAN TCAs early: nausea, anxiety, insomnia. late: anorexia, sexual dysfunction, induction of mania in bipolar
7
Q
Fluoxetine
A
- SSRI
- Oral, effects > 2 wks
- Selective for 5-HT reuptake
- Long 1/2 life
- SAFER THAN TCAs early: nausea, anxiety, insomnia. late: anorexia, sexual dysfunction, induction of mania in bipolar
8
Q
Sertraline
A
- SSRI
- Oral, effects > 2 wks
- Selective for 5-HT reuptake
- Long 1/2 life
- SAFER THAN TCAs early: nausea, anxiety, insomnia. late: anorexia, sexual dysfunction, induction of mania in bipolar
9
Q
Duloxetine
A
- SNRI
- Selective for 5-HT and NE reuptake
- 11-12 h 1/2 life
- Nausea, anxiety, insomnia, sexual dysfunction, increase in HR/BP
- Contraindicated in pts with hepatic insufficiency
10
Q
Venlafaxine
A
- SNRI
- Selective for 5-HT and NE reuptake
- 11-12 h 1/2 life
- Nausea, anxiety, insomnia, sexual dysfunction, increase in HR/BP
11
Q
Buproprion
A
- Atypical Antidepressant
- Inhibits D reuptake
- Headache, nausea, tinnitus, insomnia, nervousness
- Treats bipolar disorder
12
Q
Mirtazapine
A
- Atypical antidepressant
- Increases NE and 5-HT by blocking alpha 2 recpt.
- Headache, nausea, tinnitus, insomnia, nervousness
- Used to treat depression
13
Q
Nefazodone
A
- Atypical antidepressant
- Inhibits reuptake of 5-HT and blocks receptors
- Headache, nausea, tinnitus, insomnia, nervousness
- Used to treat depression, anti-psychotic
14
Q
Phenelzine
A
- MOAI
- Increases presynaptic conc. of monoamines
- Restlessness, agitation, psychosis, orthostatic hypertension, tachycardia, serotonin syndrome, cheese effect
- Used to treat aytipical depression
15
Q
Tranylcypromine
A
- MOAI
- Increases presynaptic conc. of monoamines
- Restlessness, agitation, psychosis, orthostatic hypertension, tachycardia, serotonin syndrome, cheese effect
- Used to treat aytipical depression
16
Q
Lithium
A
- Bipolar treatment drug of choice
- Oral administration
- Prevents PI signaling, inhibits serotonin receptors, enhances glutamate reuptake
- VERY TOXIC, tremors, confusion, convulsions, coma arrhythmias, decreased thyroid function, polydipsia, polyuria, teratogen
17
Q
Atomexetine
A
- Stimulant
- NE reuptake inhibitor, non habit forming
- ADHD
18
Q
Dextro-amphetamine
Methylphenidate
Amphetamine
A
- Stimulants
- Potential for addiction
- Psychomotor stimulant, met by liver, increase release of DA and NE from synaptic vesicles
- Euphoria, anxiety, vertigo, insomnia, paranoia, psychosis, suicidal thoughts, arrhythmia, hypertension, nausea, diarrhea
- ADHD, narcolepsy
19
Q
Modafinil
A
- Stimulant
- Unknown but involves DA and NE systems
- Fewer psychotic and euphoric effects than other stimulants
- Used to treat narcolepsy
20
Q
Diazepam
Lorazepam
A
- Benzodiazepine
- Diaz = long half life, Lora = intermediate half life
- Longer 1/2 life used to treat both anxiety and convulsions
- Bind to GABA receptors and enhance inhibition
- Safer than barbiturates, tolerance after 1-6 months, drowsiness, sedation, ataxia, nausea, vomiting, skin rash, weight gain
- Used to treat anxiety, withdrawal, muscle relaxant, absence seizures, status epilepticus (IV) and generalized seizures
21
Q
Chlordiazepoxide
Alprazolam
Oxazepam
A
- Benzos
- Anti anxiety
- Ultrashort half life
- Bind to GABA receptors, increase inhibition
- Resp dep
22
Q
Midazolam
A
- Benzo
- anti anxiety, premedication for general anesthesia
- Bind to GABA receptors, increase inhibition
- Resp dep
23
Q
Flumazenil
A
- Benzo ANTAGONIST
- Short acting IV use
- Blocks effects of GABA rec agonists and inverse agonists
- Precipitate withdrawal of BZ or BARB
- Reverses BZ resp dep
24
Q
Zolpidem
Zaleplon
A
- Non-Benzo Anti Anxiety
- Can be given IV
- Act on BZ binding site of GABA rec
- Card dep in heart failure - caution
- Induce sleep
25
Pentobarbital
* BARB
* Sedating
* Anticonvulsant
* Binds GABA rec, enhances inhibition, short onset and intermediate half life
* Drowsiness, confusion, diminished motor skills and impaired judgement
* Premedication for gen anesthesia
26
Phenobarbital
* BARB
* PO prep readily absorbed into brain
* Long onset and Long 1/2 life
* Anticonvulsant and Premedication, preop sedation
* Drowsiness, confusion, diminished motor skills, impaired judgement, teratogen nausea vomiting, skin rash weight change
27
Amobarbital
* BARB
* Sedating
* Immediate onset (IV), short 1/2 life
* Preop sedation
* Drowsiness, confusion, diminished motor skills, impaired judgement
28
Thiopental
* BARB*Sedating
* Immediate onset (IV), ultra short 1/2 life
* Preop sedation
* Drowsiness, confusion, diminished motor skills, impaired judgement
* Anesthesia induction
29
Buspirone
* Misc Sedating
* 5-HT receptor AGONIST
* Met by CYP3A4, onset 1-3 weeks so not for acute use
* No dependence or withdrawal symptoms, no additive effects with EtOH
* Anti-anxiety
30
Propranolol
*Misc Sedating
31
Carbamazepine
* Bipolar treatment, anticonvulsant
* PO slowly absorbed, highly lidid soluble
* Inhibits V-G Na channels and reduces firing
* Drowziness, sedation, ataxia, nausea, vomiting, skin rash weight gain/loss hepatotoxicity, teratogen
32
Valproic Acid
* Bipolar treatment, anticonvulsant
* PO-high plasma protein binding, met by liver P450
* Inhibits V-G Na channels and reduces firing, also inhibits GABA
* Drowziness, sedation, ataxia, nausea, vomiting, skin rash weight gain/loss hepatotoxicity, teratogen, thrombocytopenia
33
Chlorpromazine
* Antipsychotic, phenothiazine
* Selective antagonist for D2 recept. Low potency
* Hyperthermia, tachycardia, urinary retention, memory impairment, blurred vision, constipation, confusion, vasodilation, orthostatic hypotension, sexual dysfunction and weight gain
34
Haloperidol
| Fluphenazine
* Antipsychotic, phenothiazine
* Selective for D2 rec. HIGH potency
* Hyperthermia, tachycardia, urinary retention, memory impairment, blurred vision, constipation, confusion, vasodilation, orthostatic hypotension, sexual dysfunction and weight gain
35
Thiothixene
* Antipsychotic thioxanthene
* Selective for D2 medium potency
* Can increase prolactin release, infertility and impotence
* Psychosis
36
Risperidone
| Paliperidone
* Bipolar treatment, atypical antipsychotic
* Inhibits both D2 and 5-HT rec
* Sedation and weight gain
* Treats psychosis
37
Olanzapine
* Atypical antipsychotic
* Inhibits D2 and 5-HT rec
* Hyperthermia, tachycardia, urinary retention, memory impairment, blurred vision, constipation, confusion, vasodilation, orthostatic hypotension, sexual dysfunction and weight gain
38
Clozapine
* Atypical antipsychotic
* Inhibits D2 and 5-HT rec
* Hyperthermia, tachycardia, urinary retention, memory impairment, blurred vision, constipation, confusion, vasodilation, orthostatic hypotension, sexual dysfunction and weight gain
39
Quetiapine
* Atypical antipsychotic
* Inhibits D2 and 5-HT rec
* Hyperthermia, tachycardia, urinary retention, memory impairment, blurred vision, constipation, confusion, vasodilation, orthostatic hypotension, sexual dysfunction and weight gain
40
Aripiprazole
* Atypical antipsychotic
* weak D2 agonist and 5-HT rec antagonist
* Hyperthermia, tachycardia, urinary retention, memory impairment, blurred vision, constipation, confusion, vasodilation, orthostatic hypotension, sexual dysfunction and weight gain
41
Prochlorperazine
| Promethazine
* Antiemetic, Antipsychotic
| * D2 receptor blockade and H1 receptor blockade
