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psych pharm Flashcards

(107 cards)

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1
Q

chlorpromazine

A

1st gen APS

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2
Q

fluphenazine

A

1st gen APS

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3
Q

haloperidol

A

1st gen APS

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4
Q

perphenazine

A

1st gen APS

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5
Q

1st gen APS MOA

A

D2 antag

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6
Q

1st gen APS SE

A

EPS, NMS, tardive dyskinesia

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7
Q

EPS

A

dystonia
oarkinsonism
akathesia

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8
Q

tx for EPS

A

anticholinergics (benztropine, diphenhydramine), benzos/betablockers

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9
Q

Tx for tardive dyskinesia

A

d/c meds

benzoa, botox, vit E

mvts may persist even with removal of the drug

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10
Q

NMS

A

change in mental status, fever, labile BP, lead pipe rigidity, elevated CPK

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11
Q

aripiprazole

A

2nd gen APS

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12
Q

asenapine

A

2nd gen APS

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13
Q

clozapine

A

2nd gen APS

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14
Q

iloperidone

A

2nd gen APS

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15
Q

lurasidone

A

2nd gen APS

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16
Q

olanzapine

A

2nd gen APS

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17
Q

quetiapine

A

2nd gen APS

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18
Q

risperidone

A

2nd gen APS

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19
Q

ziprasidone

A

2nd gen APS

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20
Q

2nd gen APS MOA

A

antag 5HT2 and D4>D2

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21
Q

SE of 2nd gen APS

A

metabolic syndrome

agranulocytosis with clozapine

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22
Q

metabolic syndrome

A

inc BP, inc blood sugar levels, excess body fat around the waist, abnormal cholesterol levels, inc risk for CV, stroke and type II diabetes

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23
Q

serotonin syndrome

A

autonomic instability, diaphoresis, , tachycardia, fever, hyperreflexia, seizures, coma, death

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24
Q

what 2 drugs combined are high risk for serotonin syndrome

A

SSRI and MAOI

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25
What meds cause HAM SE?
TCAs and low potency APS
26
What meds cause HTN crisis?
MAOI with tyramine rich foods
27
Blockage of what tract is crucial to the efficacy of APS and why?
mesolimbic tract bc excessive dopamine transmission in this area causes pos sx of schizophrenia
28
APS blockage of dopamine in what tract causes cognitive dysfunction
mesocortical tract
29
APS blockage of dopamine in what tract causes hyperprolactinemia
tuberoinfundibular tract
30
APS blockage of dopamine in what tract causes EPS
nigrostriatal tract
31
Antagonism of histamine 1
sedation and weight gain
32
Muscarinic receptor blockade
blurred vision, dry mouth, urinary retention, constipation, and decreased cognition
33
Inhibition of alpha-1 adrenergic receptors
sedation, orthostatic hypotension, and reflex tachycardia
34
What meds have HAM SE?
TCA and low potency APS
35
What APS cause hyperprolactinemia
typicals and risperidone
36
Paroxetine
SSRI- short HL causing withdrawal sx
37
Fluvoxamine
SSRI- only approved for OCD
38
Fluoxetine
SSRI- longest HL, safe in children and in pregnancy
39
Sertraline
SSRI- higher risk for GI disturbances
40
venlafaxine
SNRI
41
duloxetine
SNRI
42
Mirtazpine
alpha 2 adrenergic antagonist- good for depression in elderly with insomnia and anorexia
43
Tx for TCA overdose
IV sodium bicarbonate
44
Amitriptyline
TCA- good for chronic pain and insomnia
45
Imipramine
TCA- good for enuresis and panic d/o
46
Clomipramine
TCA- good for OCD
47
Doxepine
TCA
48
Nortriotyline
TCA
49
Desipramine
TCA
50
TCA SE
HAM- sedation, wt gin, CV SE, dry mouth, seizures, lethal in OD
51
Phenelzine
MAOI
52
Tranylcypromine
MAOI
53
Isocarboxazid
MAOI
54
Selegiline
MAOI
55
Chlorpromazine
1st gen APS | deposits in lens and cornea, blue-gray skin discoloration
56
thioridazine
1st gen APS | associated with retinitis pigmentosa
57
thiothixene
mid potency 1st gen APS
58
loxapine
mid potency 1st gen APS
59
molindone
mid potency 1st gen APS
60
perphenazine
mid potency 1st gen APS
61
fluphenazine
high potency 1st gen APS
62
pimozide
high potency 1st gen APS
63
tx for akathesia SE
beta blockers or benzos
64
Tx of EPS SE
benztropine or diphenhydramine | sometimes amantadine
65
Onset of NMS SE
usually early but can be anytime
66
Onset of acute dystonia
hrs to days
67
Onset of parkinsonism/akathesia
days to weeks
68
onset of TD
6 months to years
69
clozapine
2nd gen APS agranulocytosis- stop if ANC < 1500 ONLY APS shown to dec risk of suicide
70
risperidone
2nd gen APS | increased prolactin
71
quetiapine
2nd gen APS
72
olanzapine
2nd gen APS | weight gain and sedation
73
ziprasidone
2nd gen APS | QTc prolongation, must be taken with food at least 300 cal
74
aripiprazole
2nd gen APS | less potential for weight gain
75
What is the only mood stabilizer shown to decrease suicidality
lithium
76
SE of APS
metabolic syndrome- monitor with baseline weight, BP, fasting glucose and fasting lipids weight gain, hyperlipidemia and hyperglycemia some anti-HAM effects elevated LFTs QTc prolongation
77
What should you monitor with lithium
lithium levels, creatine and thyroid function tests
78
SE of lithium
tremor, nephrogenic diabetes insipidus, GI disturbance, weight gain, sedation, thyroid enlargement, hypothyroidism, ecg changes, benign leukocytosis, Ebsteins anolomy in babies of mothers taking lithium
79
Carbamazepine class and SE
anticonvulsant/mood stabilizer SE- GI and CNS, can cause SJS, agranulocytosis and teratogenic
80
valproic acid
anticonvulsant/mood stabilizer must monitor LFT and CBC, CI in pregnancy
81
lamotrigine
anticonvulsant/mood stabilizer SE- dizziness, sedation, HA, SJS
82
Gabapentin
anticonvulsant good for neuropathic pain, anziety and sleep
83
preganalin
anticonvulsant food for GAD and fibromalagia
84
Toprimate
anticonvulsant good for impulse control disorders with beneficial SE of weight loss
85
SE of anticonvulsants
hepatotoxic and teratogenic, alopeica, GI sx, pancreatitis
86
What benzos are good for chronic alcoholics or liver dz pts
Lorazepam Oxazepam Temazepam
87
How do BZD work
potentiate effects of GABA
88
diazepam
BZD LA | detox from alc
89
clonazepam
BZD LA anxiety and panic attacks avoid with renal fn pts
90
alprazolam
BZD intermediate | anxiety/PA
91
lorazepam
BZD intermediate | anxiety, alc detox
92
oxazepam
BZD intermediate | alc detox
93
temazepam
BZD intermediate
94
triaozolam
BZD SA | incomnia tx
95
midazolam
BZD SA
96
BZA toxicity
respiratory depression esp when combined with alcohol
97
zolpidem
non-BZD hypnotic | insomnia
98
diohenhydramine and ramelteon
non-BZD hypnotic
99
buspirone
non-BZD anxiolytics | used in combo with SSRI for GAD
100
hydroxyzine
non-BZD anxiolytics
101
propranolol
non-BZD anxiolytics good for performance anxiety
102
atomoxetine
psychostimulant less abuse but less effective in ADHD
103
modafinil
psychostimulant used in narcolepsy
104
doneppezil
ach inhibitor used in mild to mod neurocog d/o
105
galantamine
ach inhibitor used in mild to mod neurocog d/o
106
rivastigmine
ach inhibitor used in mild to mod neurocog d/o
107
memantine
NMDA receptor antag mod to severe neurocog d/o

Behavioral Medicine EOR (11 decks)

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