Psychiatric Disorders Flashcards
(53 cards)
depression is more common in:
elderly, teenagers and chronic pain patients
major depression is a serious:
potentially life threatening situation
what are the diagnostic criteria for major depression
- at least one of the symtpoms is either
- low mood
- anedonia (no longer enjoys pleasureable activities)
- 5 or more of the following symptoms for more than 2 weeks:
- low energy
- sleep changes: daily insomnia or hypersomnia
- significant weight loss/decreased apetite
- suicidal thoughts
- pscyhomotor agitation/retardation
- poor concentration
- irritability
- feeling worthless or inappropriate guilt
major depression =
5 out of 9 symptoms for longer than 2 weeks
major depression affects:
social function
what is the physiology of major depression
- locus ceruleus- produces NE
- raphe nucleus - produces serotonin
- left frontal cortex and brainstem
- brain is either firing too fast or too slow in releasing NE and serotonin
what is the physiology of depression vs anxiety
- depression: less serotonin, more postsynaptic receptors, firing rates of neurons are faster because they have a hypersensitive neurosynaptic junction. causes upregulation
- anxiety- firing rates of neurons are too slow
_______ of people with depression have anxiety
100%
depression is more common in individuals who as children experiences:
- abuse
- shyness
- high rejection sensitivity
- eagerness to please
- introverts
people in alpha personality positions have increased:
serotonin
describe SSRIs
- prozac and paxil
- inhibit reuptake of serotonin at nerve junction
- initially this increases firing rate for 2-3 weeks
_____ of people feel worse with SSRIs
30%
SSRIs take _____ to work to down regulate neurons
4 weeks
SSRIs reduce:
rejection sensitivity
what are the depression symptoms
- ask patient how long they have been feeling down, if they have problems with sleep and apetite
- early morning dysphoria
what is early morning dysphoria
waking up in the morning feeling down regularly. this is the worst and pathognomonic symptom
grieving individuals usually have their worst symptom in:
the evening
the most sensitive symptom is:
mild depression
what is the main symptom of depression
irritability
mild depression begins to act like:
a chronic stressor
cortisol affects:
NMDA receptor -> neuronal firing -> kills brain cells in amygdala and hippocampus
depression symptoms cause decreased _______ if patient does not get immediate treatment
brain mass
what happens to platelets
they spike causing clotting over time
what happens to BP in depression
increased which destroys lining of blood vessels and cause plaques