Psychiatric Medication Formulary CYP and SE

Question 1

Amitriptyline (Elavil)

Answer 1

2D6 substrate

Anticholinergic effects, cardiovascular, wt gain

Question 2

Aripiprazole (Abilify)

Answer 2

3A4/2D6 substrate

akathisia/anxiety

Question 3

Asenapine (Saphris)

Answer 3

1A2 substrate

wt gain, QTc prolongation

Question 4

Bupropion (Wellbutrrin/Zyban)

Answer 4

2B6 substrate

insomnia/appetite suppression

Question 5

Chlorpromazine (Thorazine)

Answer 5

2D6 substrate/inhibitor

EPS, drowsiness, or rash

Question 6

Citalopram (Celexa)

Answer 6

2C19 substrate

akathisia, sedation, sexual dysfunction

Question 7

Clozapine (Clozaril)

Answer 7

1A2 substrate

Agranulocytosis, cardiomyopathy

Question 8

Desvenlafaxine (Pristiq)

Answer 8

renal excretion

sedation, nausea, increased bp, GI upset

Question 9

Fluvoxamine (Luvox)

Answer 9

1A2 inhibitor

indicated for OCD, sedation, sexual dysfunction

Question 10

Levomilnacipran (Fetzima)

Answer 10

3A4 substrate

sedation, nausea, increased bp, GI upset

Question 11

Lurasidone (Latuda)

Answer 11

3A4 substrate

take with food, prominent akathisia

Question 12

Milnacipran (Savella)

Answer 12

renal excretion

not indicated for depression, sedation, nausea, increased BP

Question 13

Olanzapine (Zyprex)

Answer 13

1A2 substrate

significant wt gain, metabolic syndrome risk

Question 14

Quetiapine (Seroquel)

Answer 14

3A4 substrate

QTc prolongation, abuse potential

Question 15

Risperidone (Risperdal)

Answer 15

2D6 substrate

EPS, hyperprolactinemia

Question 16

Sertraline (Zoloft)

Answer 16

2C19/2D6 substrate

GI at higher doses, sexual dysfunction, sedation

Question 17

Trazodone (Desyrel)

Answer 17

3A4 substrate

priapism, clinically more useful for insomnia

Question 18

Venlafaxine (Effexor)

Answer 18

3A4/2D6 substrate

dose must be > 150mg for NE effects, elevated BP, sexual dysfunction

Question 19

Vilazodone (Viibryd)

Answer 19

3A4 substrate

insomenia, nausea, diarrhea

Question 20

Vortioxetine (Brintellix)

Answer 20

2D6 substrate

N/V, constipation

Question 21

Ziprasidone (Geodon)

Answer 21

aldehyde oxidase

must take with food, QTc prolongation