Psychiatry Flashcards

(137 cards)

1
Q

What are the 3 core symptoms of depression?

A

Low mood, anergia, anhedonia

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2
Q

What are other biological symptoms of depression?

A

Changes in sleep (early morning wakening)
Changes in appetite
Change in libido
Agitation/anxiety
Diurnal mood variation

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3
Q

What are other cognitive symptoms of depression?

A

Loss of confidence
Loss of concentration
Feelings of guilt
Hopelessness
Suicidal ideation

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4
Q

What is the diagnostic criteria for mild depression?

A

Minimum 2/3 core symptoms + 2-3 other symptoms

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5
Q

What is the diagnostic criteria for moderate depression?

A

Minimum 2/3 core symptoms + 4 others

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6
Q

What is the diagnostic criteria for severe depression?

A

Core symptoms + several other symptoms + suicidal thoughts +/- psychotic symptoms

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7
Q

What are examples of SSRIs?

A

Sertraline
Fluoxetine
Paroxetine
Citalopram

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8
Q

For what disorders can SSRIs be used?

A

Depression
Generalised Anxiety Disorder
PTSD
OCD

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9
Q

What are the side effects of SSRIs?

A

Excessive stimulation of cerebral serotonin receptors (insomnia, anxiety, irritability)
Excessive stimulation of spinal serotonin receptors (sexual dysfunction)
Excessive stimulation of GI serotonin receptors (Nausea, vomiting, diarrhoea)

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10
Q

What are the symptoms of abrupt SSRI discontinuation?

A

Increased mood change
Restlessness
Difficulty sleeping
Unsteadiness
Sweating
GI symptoms
Paraesthesia and electric shock-like sensations

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11
Q

What are examples of SNRIs?

A

Duloxetine
Venlafaxine
Levomilnacipran

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12
Q

For what disorders can SNRIs be used?

A

Depression
Generalised Anxiety Disorder
Panic disorders
Fibromyalgia
Neuropathy

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13
Q

What are the side effects of SNRIs?

A

Excessive stimulation of cerebral serotonin receptors (insomnia, anxiety, irritability)
Excessive stimulation of spinal serotonin receptors (sexual dysfunction)
Excessive stimulation of GI serotonin receptors (Nausea, vomiting, diarrhoea)
PLUS - Excessive noradrenergic activity (hypertension, tachycardia)

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14
Q

What are examples of tricyclic antidepressants?

A

Amitriptyline
Clomipramine
Nortriptyline
Doxepin
Desipramine
Amoxapine

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15
Q

What are the uses of TCAs?

A

Migraine prevention
Neuropathic pain
Insomnia

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16
Q

What are the side effects of TCAs?

A

Inhibition of alpha receptors (orthostatic hypotension, dizziness)
Inhibition of histamine receptors (sedation)
Inhibition of muscarinic receptors (blurred vision, constipation, urinary retention, dry mouth (anticholinergic effects))
Block cardiac sodium channels (cardiac conduction abnormalities)

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17
Q

What are examples of monoamine oxidase inhibitors (MAOIs)?

A

Isocarboxazid
Phenelzine
Selegiline

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18
Q

What are the uses of MAOIs?

A

Last choice antidepressant due to interactions with other drugs and foods

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19
Q

What are the side effects of MAOIs?

A

Interact with tyramine (eg. in cheeses, beer, red wine, fish sauces) and can cause stroke

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20
Q

What are examples of atypical antidepressants?

A

Bupropion –> Used for depression, nicotine cravings and withdrawal symptoms
Mirtazapine –> Sedation
Nefazadone
Vilazadone

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21
Q

What is first line pharmaceutical management of depression?

A

SSRIs

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22
Q

What is non-pharmaceutical management of depression?

A

CBT

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23
Q

What are the two states of bipolar disorder?

A

Depression
Mania/hypomania

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24
Q

What is hypomania?

A

A milder form of mania

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25
What symptoms are suggestive of mania?
Abnormally elevated mood Increased energy Pressure of speech Flight of ideas or racing thoughts Poor concentration Increased libido/disinhibition Extravagant plans Psychotic symptoms --> delusions (usually grandiose), hallucinations (usually voices)
26
How do you diagnose a manic episode?
Symptoms of mania lasting for at least 7 days which usually begin abruptly
27
What symptoms are suggestive of hypomania?
Mild elevation of mood/irritability Increased energy Feelings of wellbeing Increased sociability
28
How do you diagnose a mixed episode (in bipolar)?
Rapid alternation, within a few hours, of manic/hypomanic symptoms and depression
29
What symptoms may help distinguish bipolar disorder from unipolar depression?
Hypersomnia Weight instability Early age of onset Abrupt onset More frequent episodes of shorter duration History of substance misuse Psychosis, psychomotor retardation, catatonia Family history of bipolar disorder
30
What is the diagnostic criteria for Bipolar I?
Mania + depression
31
What is the diagnostic criteria for Bipolar II?
Many episodes of depression + hypomania
32
What therapies are used to manage bipolar disorder?
CBT Interpersonal therapy
33
What is first line pharmaceutical treatment of bipolar disorder?
Antidepressant (fluoxetine) + antipsychotic (olanzapine, quetiapine, haloperidol, risperidone) for an acute manic episode Lithium (mood stabiliser) or valproate for long term management
34
What are examples of typical antipsychotics?
Haloperidol Fluphenazine Chlorpromazine Prochlorpromazine
35
What are the uses of typical antipsychotics?
Reduce positive schizophrenia symptoms (delusions, hallucinations)
36
What are the side effects of typical antipsychotics?
Worsening of negative schizophrenia symptoms (anergia, lack of motivation, social disengagement) Extrapyramidal disorders Increased prolactin (sexual dysfunction, gynaecomastia, galactorrhoea) Chlorpromazine --> Orthostatic hypotension, anticholinergic symptoms (eg. dry mouth, blurred vision, constipation, urinary problems), sedation, weight gain
37
What can be given to prevent and treat extra-pyramidal side effects of antipsychotics?
Anti-cholinergic drugs (eg. procyclidine)
38
What are examples of atypical antipsychotics?
Aripiprazole Olanzapine Risperidone Paliperidone Clozapine Quetiapine
39
What are the uses of atypical antipsychotics?
Reduce positive and negative schizophrenic symptoms Reduces extrapyramidal side effects Improves cognition compared with typical antipsychotics
40
What are side effects of atypical antipsychotics?
Weight gain Sedation Orthostatic hypotension Hyperglycaemia/hyperlipidaemia Constipation Nausea/vomiting
41
What are the first rank symptoms of schizophrenia?
Thought alienation Passive phenomena 3rd person auditory hallucination Delusional perception (Only need 1 of the above for diagnosis)
42
What are the secondary symptoms of schizophrenia?
Delusions 2nd person auditory hallucinations Thought disorders Catatonic behaviours (Need at least 2 of the above for diagnosis)
43
What symptoms can be associated with Generalised Anxiety Disorder?
Excessive anxiety Lasting for 6+ months Tiredness Poor concentration Irritability Muscle tension Initial insomnia (difficulty falling asleep)
44
What are physical symptoms associated with panic disorder?
Palpitations Chest pain Tachypnoea Urgency Dizziness
45
What are psychological symptoms associated with panic disorder?
Feelings of impending doom Fear of dying Fear of losing control Depersonalisation Derealisation
46
What are examples of benzodiazepines?
Alprazolam Diazepam Clonazepam Lorazepam
47
What are some side effects of benzodiazepines?
Drowsiness Dizziness Decreased concentration
48
What are the uses of benzodiazepines?
Insomnia Anxiety Muscle relaxants
49
Which personality disorders belong to cluster A (odd/eccentric)?
Schizoid (lack of interest in social interaction) Paranoid (patterns of distrust and suspicion without reasonable cause) Schizotypal (mild form of schizophrenia where someone has few, if any, close relationships and doesn't seem to understand how relationships form and how their behaviour impacts others, also quite eccentric)
50
Which personality disorders belong to cluster B (dramatic/erratic)?
Emotionally unstable/Borderline Histrionic (feel uncomfortable if not at the centre of attention) Narcissistic (inflated sense of self importance) Dissocial (converted from antisocial PD at 18 years old, antisocial behaviour can include impulsivity, irresponsibility and crime)
51
Which personality disorders belong to cluster C (anxious/fearful)?
Obsessive-Compulsive Personality Disorder/Anankastic (preoccupation with orderliness, perfection and control) Dependent (feelings of helplessness and submissiveness and inability to take care of themselves) Avoidant (chronic feelings of inadequacy and fear of rejection)
52
What are the clinical features of EUPD?
Impulsivity --> can manifest as substance abuse, eating disorders, sexual/risk taking behaviours, self-harm, overspending Intense unstable relationships Fear of abandonment Unstable mood Feelings of emptiness Thoughts of self-harm/suicide Uncertainty around self-image
53
What are the conditions of self-harm in EUPD?
Tends to not be suicidal but instead aims to relieve psychic pain Inflict self-punishment Reduce anxiety/re-establish control Shout for help
54
What are the principles of management in EUPD?
Validating, containing, compassion Consistency Medication is often unreliable Gold standard therapy is Dialectical Behavioural Therapy --> Self-soothing and distraction techniques
55
For which disorders is CBT approved?
Depression Anxiety OCD PTSD Eating disorders Psychosis
56
For which disorders is interpersonal therapy used?
Mild/moderate depression --> helps the patient to understand how their problems are connected to their relationships
57
For which disorders is dialectical behavioural therapy used?
EUPD/BPD
58
What is involved in section 2 of the Mental Health Act?
Used for detainment for assessment of a patient Maximum 28 days and cannot be renewed Requires 1 section 12 registered doctor and any other registered practitioner
59
What is involved in section 3 of the Mental Health Act?
Used for detainment for treatment of a patient 6 months and can be renewed Requires 1 section 12 registered doctor and any other registered practitioner
60
What is involved in section 4 of the Mental Health Act?
Used for urgent necessity for when a second doctor is unavailable Maximum 72 hours for assessment 1 doctor + 1AMHP
61
What is involved in section 5 (2) of the Mental Health Act?
Used as a doctor's holding power for admitted patients to allow for assessment for sections 2 or 3 Maximum 72 hours Does not allow treatment
62
What is involved in section 5 (4) of the Mental Health Act?
Used as a nurse's holding power for an admitted patient who wants to leave, until a doctor can arrive Maximum 6 hours Does not allow for treatment
63
What is involved in section 12 of the Mental Health Act?
The ability of a doctor to make decisions about detainment of a patient in sections 2 or 3
64
What is involved in section 135 of the Mental Health Act?
Allows for the police to access a person's home and remove them on the basis of poor mental health and transport them to a place of safety to allow for further assessment
65
What is involved in section 136 of the Mental Health Act?
Allows for the police to detain an individual suspected of having a mental disorder in a public place and transport them to a place of safety to allow for further assessment
66
What are the symptoms of alcohol withdrawal?
Anxiousness/nervousness Irritability Depression Fatigue Tremor Mood swings Loss of concentration Night sweats Headache Difficulty sleeping Nausea/vomiting Loss of appetite
67
What are the clinical signs of alcohol withdrawal?
Tremor Tachycardia Hypertension Dilated pupils Fever Tachypnoea
68
What is the management of mild/moderate alcohol withdrawal?
Often able to withdraw at home with help Benzodiazepine sedative (eg. chlordiazepoxide) Test for other comorbidities associated with alcohol use Counselling for alcohol use
69
What is the management of moderate/severe alcohol withdrawal?
Often hospitalised for monitoring IV fluids IV sedatives Treat seizures or any other complication Supportive to stop drinking
70
What are the symptoms of delirium tremens?
Fever Extreme agitation Seizures Extreme confusion Hallucinations Hypertension Tachycardia Hyperthermia Extreme sweating
71
What are the risk factors for delirium tremens?
Past history of delirium tremens Past history of seizures Concurrent illness History of detoxification Prolonged period prior to last drink
72
What is the cause of delirium tremens?
Severe alcohol withdrawal
73
What is the treatment of delirium tremens?
IV benzodiazepines IV Pabrinex (Vitamin B1) --> Prevent Korsakoff's syndrome Control and treat symptoms
74
What is Wernicke's encephalopathy?
Thiamine deficiency
75
What are the signs of Wernicke's encephalopathy?
Altered mental state Ophthalmoplegia (extraocular muscle paralysis) Ataxic gait Delirium Hypotension Nystagmus
76
What are the risk factors of Wernicke's encephalopathy?
Chronic alcohol abuse Chronic malnutrition
77
What are the causes of Wernicke's encephalopathy?
Severe alcohol use Severe malnutrition Hyperemesis gravidarum (severe vomiting in pregnancy) Malignancy Liver disease Hyperthyroidism
78
How can you diagnose Wernicke's encephalopathy?
Clinical triad of altered mental state, ophthalmoplegia and ataxic gait
79
What is the treatment of Wernicke's encephalopathy?
IV thiamine
80
What are the symptoms of severe lithium toxicity?
Hyperreflexia Seizures Agitation Slurred speech Kidney failure Tachycardia Hyperthermia Nystagmus Hypotension Confusion
81
What is the treatment of lithium toxicity?
Decontamination --> Charcoal, gastric lavage, whole bowel irrigation Elimination --> Haemodialysis
82
What is the difference between illusion and hallucination?
Both are false perceptions, but whereas illusions are due to a misinterpretation of a stimulus arising from an object, hallucinations do not involve an object
83
What is a hypnagogic hallucination?
A hallucination that occurs when falling asleep
84
What is a hypnopompic hallucination?
A hallucination that occurs when waking up
85
What is the definition of a over-valued idea?
A false belief that is maintained despite strong evidence that it is untrue (eg. an anorexic patient believing that they are fat)
86
What is the definition of a delusion?
A belief held with unshakeable conviction that cannot be altered by rational arguement and is outside the person's normal cultural belief system
87
What is delusional perception?
Belief that a normal event has a special meaning for them
88
What is thought alienation?
Feelings that an individual's thoughts are no longer in their control
89
What is thought insertion?
Where an individual believes that a thought has been inserting into their head
90
What is thought withdrawal?
Where an individual believes that their thoughts have been taken out of their head by an external source
91
What is thought broadcast?
Belief that the individual's life story is being told to everyone
92
What is thought echo?
A form of hallucination where the individual hears their own thoughts out loud after they have thought them
93
What is thought block?
A sudden halting of thoughts, causing the individual to stop speaking mid sentence
94
What is loosening of association?
Where an individual jumps between unrelated ideas when talking
95
What is circumstanitality?
Where an individual talks irrelevantly around the point
96
What is perseveration?
Where an individual repeats a word/theme/action beyond the point of relevance
97
What is confabulation?
Where a gap in the memory is filled with false content
98
What is somatic passivity?
Where the individual passively receives bodily sensations that are imposed from outside forces
99
What is the definition of delirium?
A serious mental disturbance causing confusion and reduced awareness of the surroundings
100
What is the definition of catatonia?
A state of excited motor activity in the absence of mood or neurological disorder
101
What is flight of ideas?
Where thoughts are formed quickly, causing the individual to talk quickly and jittery
102
What is poverty of speech?
Where speech is difficult to form and only comes in order to answer a question
103
What is poverty of thought?
Where speech is adequate in quantity but is vague and lacks meaningful content
104
What is pressure of speech
A tendency to speak rapidly and frenziedly
105
What is anhedonia?
The inability to experience emotion
106
What is apathy?
A lack of interest
107
What is flattening of affect?
No emotional expression
108
What is blunting of affect?
Significantly reduced emotional expression
109
What is incongruity of affect?
Emotional response out of time with the scenario
110
What is Belle indifference ("Beautiful ignorance")?
A lack of concern by an individual to their symptoms
111
What is depersonalisation?
A feeling of being outside oneself and passively observing ones actions
112
What is derealisation?
A feeling that the world around an individual is unreal
113
What is the definition of an obsession?
An intrusive thought that intrudes into consciousness and cannot be easily removed
114
What is the definition of a compulsion?
A repetitive behaviour that an individual feels the need to do to temporarily relieve an unpleasant feeling brought on by an obsessive thought
115
What is Othello syndrome?
Delusional jealousy, usually believing that their partner is being unfaithful
116
What is Fregoli syndrome?
Delusional belief that one or more familiar people are repeatedly changing their appearance
117
What is Folie a deux?
A mental disorder shared by two people at the same time
118
What is factitious disorder/Munchausen disorder?
Where someone deceives others by appearing sick or purposely getting sick or self harming Can also happen by presenting others, such as children, as being ill
119
What is Cotard syndrome?
When a patient believes that they are dead or non-existent
120
What is Capgras syndrome?
When the patient believes that a relative or friend has been replaced by an identical imposter
121
What is Charles Bonnet syndrome?
Where patients with vision loss have vivid, recurrent visual hallucinations
122
What is De Clerambault syndrome/erotomania?
When a patient believes that another individual is infatuated with them, often with the other person being imaginary, deceased or unknown
123
What is somatisation disorder?
Significant focus on a physical symptoms that causes significant distress and/or problems functioning
124
What is hypochondrial disorder?
An exaggeration of present symptoms and belief that there is an underlying serious disease eg. cancer
125
What is conversion disorder?
Where a patient experiences motor or sensory neurological symptoms that cannot be explained with medical evaluation
126
What is malingering?
Feigning or exaggeration of symptoms for financial/material gain
127
What is dissociative disorder?
Where the patient feels disconnected from the world around them
128
What is tangentiality?
Where a patient talks around the point without ever answering the question asked
129
What drugs should be avoided when taking SSRIs?
Triptans --> cause Serotonin Syndrome
130
What are the signs and symptoms of serotonin syndrome?
Agitation/restlessness Insomnia Confusion Hypertension Tachycardia Pupil dilation Muscle rigidity Twitching Sweating Diarrhoea Headache Shivering
131
What is the cause of serotonin syndrome?
Excess serotonin build up
132
What is the management of serotonin syndrome?
Stop causative drug Activated charcoal if caused by overdose Supportive measures Benzodiazepines to control agitation
133
What are the causes of neuroleptic malignant syndrome?
Adverse reaction to antipsychotics Abrupt dopaminergic withdrawal
134
What is the presentation of neuroleptic malignant syndrome?
Change in mental state Rigidity Fever Autonomic dysfunction (tachycardia, hyper/hypotension)
135
What is the ICD-10 criteria for delirium?
Impairment of consciousness and attention Global disturbance in cognition Psychomotor disturbance Disturbance of sleep-wake cycle Emotional disturbance
136
What is the mechanism of action of benzodiazepines?
They facilitate and enhance the bonding of GABA to the GABA receptors
137
What are side effects of lithium?