Psychiatry Flashcards
(137 cards)
What are the 3 core symptoms of depression?
Low mood, anergia, anhedonia
What are other biological symptoms of depression?
Changes in sleep (early morning wakening)
Changes in appetite
Change in libido
Agitation/anxiety
Diurnal mood variation
What are other cognitive symptoms of depression?
Loss of confidence
Loss of concentration
Feelings of guilt
Hopelessness
Suicidal ideation
What is the diagnostic criteria for mild depression?
Minimum 2/3 core symptoms + 2-3 other symptoms
What is the diagnostic criteria for moderate depression?
Minimum 2/3 core symptoms + 4 others
What is the diagnostic criteria for severe depression?
Core symptoms + several other symptoms + suicidal thoughts +/- psychotic symptoms
What are examples of SSRIs?
Sertraline
Fluoxetine
Paroxetine
Citalopram
For what disorders can SSRIs be used?
Depression
Generalised Anxiety Disorder
PTSD
OCD
What are the side effects of SSRIs?
Excessive stimulation of cerebral serotonin receptors (insomnia, anxiety, irritability)
Excessive stimulation of spinal serotonin receptors (sexual dysfunction)
Excessive stimulation of GI serotonin receptors (Nausea, vomiting, diarrhoea)
What are the symptoms of abrupt SSRI discontinuation?
Increased mood change
Restlessness
Difficulty sleeping
Unsteadiness
Sweating
GI symptoms
Paraesthesia and electric shock-like sensations
What are examples of SNRIs?
Duloxetine
Venlafaxine
Levomilnacipran
For what disorders can SNRIs be used?
Depression
Generalised Anxiety Disorder
Panic disorders
Fibromyalgia
Neuropathy
What are the side effects of SNRIs?
Excessive stimulation of cerebral serotonin receptors (insomnia, anxiety, irritability)
Excessive stimulation of spinal serotonin receptors (sexual dysfunction)
Excessive stimulation of GI serotonin receptors (Nausea, vomiting, diarrhoea)
PLUS - Excessive noradrenergic activity (hypertension, tachycardia)
What are examples of tricyclic antidepressants?
Amitriptyline
Clomipramine
Nortriptyline
Doxepin
Desipramine
Amoxapine
What are the uses of TCAs?
Migraine prevention
Neuropathic pain
Insomnia
What are the side effects of TCAs?
Inhibition of alpha receptors (orthostatic hypotension, dizziness)
Inhibition of histamine receptors (sedation)
Inhibition of muscarinic receptors (blurred vision, constipation, urinary retention, dry mouth (anticholinergic effects))
Block cardiac sodium channels (cardiac conduction abnormalities)
What are examples of monoamine oxidase inhibitors (MAOIs)?
Isocarboxazid
Phenelzine
Selegiline
What are the uses of MAOIs?
Last choice antidepressant due to interactions with other drugs and foods
What are the side effects of MAOIs?
Interact with tyramine (eg. in cheeses, beer, red wine, fish sauces) and can cause stroke
What are examples of atypical antidepressants?
Bupropion –> Used for depression, nicotine cravings and withdrawal symptoms
Mirtazapine –> Sedation
Nefazadone
Vilazadone
What is first line pharmaceutical management of depression?
SSRIs
What is non-pharmaceutical management of depression?
CBT
What are the two states of bipolar disorder?
Depression
Mania/hypomania
What is hypomania?
A milder form of mania