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Genomics final > Psychiatry > Flashcards

Psychiatry Flashcards

1
Q

CYP1A2 *1A

A

Wild-type

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2
Q

CYP1A2 *1C

A

decreased function/decreased inducibility

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3
Q

CYP1A2 *1F

A

increased inducibility

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4
Q

Allele distribution

A

CYP1A21A/1F and *1F/1F accounts for 90% of the population

Therefore, high induction is most common phenotype

CYP1A21F/1F genotype result in a 22% reduction of olanzapine serum concentration as compared to the CYP1A2*1A carriers

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Genomics final (7 decks)

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