Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

USMLE - Pharmacology > Psychiatry > Flashcards

Psychiatry Flashcards

(82 cards)

Start Studying
1
Q

Methylphenidate: Family

A

CNS stimulant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Dextroamphetamine: Family

A

CNS stimulant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Methamphetamine: Family

A

CNS stimulant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

CNS Stimulant: Mechanism

A

Increases catecholamines at synaptic cleft (NE and DA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

CNS Stimulant: Use (3)

A

ADHD
Narcolepsy
Appetite control

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Haloperidol: Family

A

Antipsychotic (high potency)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Trifluoperazine: Family

A

Antipsychotic (high potency)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Fluphenazine: Family

A

Antipsychotic (high potency)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Thioridazine: Family

A

Antipsychotic (low potency)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Chlorpromazine: Family

A

Antipsychotic (low potency)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Antipsychotics: Mechanism

A

Dopamine D2 receptor antagonist (increases cAMP)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Antipsychotics: Use (4)

A

Schizophrenia (positive symptoms)
Psychosis
Acute mania
Tourette’s syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Antipsychotics: Toxicity (5)

A 
EPS side effects
Endocrine (hyperprolactinemia)
Antimuscarinic
Antihistamine
Alpha 1 blocker (hypotension)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

High potency antipsychotics: Toxicity

A

neurologic side effects (EPS)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Low potency antipsychotics: Toxicity (3)

A

Anticholinergic
Antihistamine
Alpha-1 blockade

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Evolution of EPS Side Effects:

4hr, 4day, 4wk, 4mo

A

4hr: acute dystonia (muscle spasm, stiffness, oculogyric crisis)
4day: akathisia (restlessness)
4wk: bradykinesia (parkinsonism)
4mo: tardive dyskinesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Neuroleptic malignant syndrome (4)

A

Rigidity
Myoglobinuria
Autonomic instability
Hyperpyrexia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

NMS: treatment

A 
Dantrolene
D2 agonist (bromocriptine)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Olanzapine: Family

A

Atypical antipsychotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Clozapine: Family

A

Atypical antipsychotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Quetiapine: Family

A

Atypical antipsychotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Risperidone: Family

A

Atypical antipsychotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Aripiprazole: Family

A

Atypical antipsychotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Ziprasidone: Family

A

Atypical antipsychotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Atypical antipsychotics: Mechanism
Varied effects on 5-HT2, dopamine, alpha and H1 receptors
26
Atypical antipsychotics: Use (7)
``` Schizophrenia (positive and negative) Bipolar OCD Anxiety Depression ania Tourette's syndrome ```
27
Which atypical antipsychotic most likely cause EPS? Which the least?
Risperidone - the most | Clozapine - the least
28
Clozapine: Side effect (2)
Agranulocytosis (weekly WBC monitoring) | Seizures
29
Clozapine and Olanzapine: Side effect
Weight gain
30
Ziprasidone: Side effect
Prolonged QT interval
31
Lithium: Mechanism
Inhibition of phosphoinositol cascade
32
Lithium: Use (2)
Mood stabilizer for bipolar (blocks relapse and acute manic events SIADH
33
Lithium: Toxicity (7)
``` Polyuria (ADH antagonist) Ebstein anomaly Heart blcok Hypothyroidism Tremor Sedation Edema ```
34
How is lithium cleared in the body?
Exclusively kidneys | Most is reabsorbed at proximal tubules following Na+
35
Use of what can increase lithium levels (2)
NSAIDS | Thiazide
36
Buspirone: Mechanism
Stimulates 5-HT1A receptors
37
Buspirone: Use
Generalized anxiety
38
Buspirone: Side effect
Does not cause sedation, addiction, tolerance | Does not interact with alcohol
39
Fluoxetine: Family
SSRI
40
Paroxetine: Family
SSRI
41
Sertraline: Family
SSRI
42
Citalopram: Family
SSRI
43
SSRI: Use (7)
``` Depression Generalized anxiety disorder Panic disorder OCD Bulimia Social phobias PTSD ```
44
SSRI is contraindicated in what?
Acute mania
45
SSRI: Side effect (3)
Serotonin syndrome Sexual dysfunction GI distress Fewer Side effects than TCAs
46
Serotonin syndrome (7)
``` Hyperthermia Confusion Myoclonus Cardiovascular collapse Flushing Diarrhea Seizures ```
47
Serotonin syndrome: Treatment
Cyproheptadine (5-HT2 receptor antagonist)
48
Venlafaxine: Family
SNRI
49
Duloxetine: Family
SNRI
50
SNRI: Use (3)
Depression Generalized anxiety (Venlafaxine) Diabetic peripheral neuropathy (Duloxetine)
51
Which SNRI has greater effect on NE?
Duloxetine
52
SNRI: Side effect (4)
Increased BP Stimulant effects Sedation Nausea
53
Amitriptyline, Nortriptyline,: Family
TCA
54
Imipramine, Desipramine, Clomipramine: Family
TCA
55
Doxepin: Family
TCA
56
Amoxapine: Family
TCA
57
TCA: Mechanism
Blocks reuptake of NE and 5HT
58
TCA: Use (4)
Major depression Bedwetting (imipramine) OCD (Clomipramine) Fibromyalgia
59
TCA: Toxicity (5)
Convulsion, Coma, Cardiotoxicity Respiratory depression hyperpyrexia Anticholinergic (3 TCA more)
60
Which TCA has higher anticholinergic side effects?
Amitriptyline
61
Which TCA has lower anticholinergic side effects?
Nortriptyline
62
Which TCA is less sedating but has higher seizure threshold?
Desipramine
63
TCA Cardiovascular toxicity: Treatment
NaHCO3
64
Tranylcypromine: Family
MAO inhibitor
65
Phenelzine: Family
MAO inhibitor
66
Isocarboxazid: Family
MAO inhibitor
67
Selegiline
selective MAO-B inhibitor
68
MAO inhibitors: Use (3)
Atypical depression Anxiety Hypochondriasis
69
MAO inhibitors: Side effects (2)
Hypertensive crisis | CNS stimulation
70
What causes hypertensive crisis of MAO inhibitors?
Ingestion of tyramine (wine and cheese)
71
What medications cause serotonin syndrome?
``` TCA SSRI MAO inhibitors St. John's wort Meperidine Dextromethorphan ```
72
Bupropion: Mechanism
Increase NE and DA
73
Bupropion: Use (2)
Smoking Cessation | Depression
74
Bupropion: Side effects (3)
Stimulant effects (tachycardia, insomnia) Headache Seizures in bulimic patients
75
Which depression medication does not cause sexual side effect?
Bupropion
76
Mirtazapine: Mechanism
Alpha-1 antagonist (Increases NE and Serotonin) | Potent 5-HT2 and 5-HT3 receptor antagonist
77
Mirtazapine: Side effects (4)
Sedation (desirable for insomnia) Increased appetite Weight gain (desirable for elderly or anorexic) Dry mouth
78
Maprotiline: Mechanism
Blocks NE reuptake
79
Maprotiline: Side effects (2)
Orthostatic hypotension | Sedation
80
Trazodone: Mechanism
Serotonin reuptake inhibitor
81
Trazodone: Use (2)
Low dose: insomnia | High dose: antidepressant
82
Trazodone: Side effects (4)
Sedation Nausea Priapism Postural hypotension

USMLE - Pharmacology (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions