Psychopharmacology Flashcards
1
Q
Different drug groups with example
A
Antidepressants - TCA’s, SSRI’s, MAOI’s
* Antipsychotics - Typical and Atypical
* Mood stabiliser - Lithium
* Minor tranquilisers - Benzodiazepines
2
Q
What are tricyclic antidepressants
A
- inhibits reuptake of noradrenaline into monoaminergic nerve terminals
- increases availability of neurotransmitters in synaptic cleft and facilitates neurotransmission in brain
3
Q
Side effects of tricyclic antidepressants
A
- dry mouth
- urinary retention
- constipation
- postural hypotension
4
Q
what do selective serotonin reuptake inhibitors do
A
- blockes reuptake of serotonin from synapse into serotonergic nerve terminals
5
Q
selective serotonin reuptake inhibitors side effects
A
- nausea
- anorexia
- tremor
- insomnia
6
Q
mechanism of antipsychotic action
A
- blocks D2 type receptors in mesolimbic area of brain.
7
Q
mechanism of benzodiazepines
A
- binds to regulatory site on GABBA and enhance response to inhibitory neurotransmitters
8
Q
side effects of benzodiazepines
A
- long lasting hangover effects and physical and psychological dependence
9
Q
Selective serotonin reuptake examples
A
fluoxitine (prozac), citalopram
10
Q
Advantages of Advantages of Selective serotonin reuptake (SSRI)
A
Lack of anticholinergic and CV effects
Acute toxicity less than MAOIs or TCAs, so less risk of death by overdose
No food reactions
11
Q
what is benzodiazepine used for
A
- reduction in anxiety and aggression
- sedation leading to improvement of insomnia and preoperatively
- muscle relaxation (antispasmodics) and loss of coordination
- suppression of convulsions
- useful in alcohol withdrawal
