Psychosis Flashcards
(27 cards)
What is lithium carbonate used for?
mood stabilization
What is MOA of lithium?
not completely known
increases serotonin synthesis
Lithium side effects?
lethargy
dizziness
confusion
tremors
N/V
polyuria/nocturia
What can increase lithium toxicity?
NSAIDS
exercise
haloperidol - increased risk of neurotoxicity
What is etiology of schizophrenia?
genetics
environment
abnormal dopaminergic pathways
NOT COMPLETELY KNOWN
“positive” sxs of schizophrenia? (surplus, more elevated)
hallucinations
delusions
paranoia
agitation
“negative” sxs schizophrenia? (taking away)
withdrawal
lack of ability to perform ADLs
poor judgement
cognitive sxs schizophrenia?
deficits in long term memory
difficulty following instructions
difficulty completing tasks
inability to focus
Are extrapyramidal symptoms (EPS) reversible?
No
What type of drug is haloperidol?
dopamine antagonist
antipsychotic; non phenothiazine
MOA of haloperidol?
depresses cerebral cortex, hypothalamus, and limbic system
Side effects of haloperidol?
weight gain
anemia
anticholinergic
respiratory depression
Contraindications and cautions of haloperidol?
parkinson’s
seizure disorders
alcoholism
CNS depression
lactation
dementia-related psychosis
MOA of risperidone?
block various dopamine
Side effects of risperidone?
“whisper”idone want to whisper about side effects
elevated prolactin levels: nipple excretions, gynecomastia, menstrual irregularities
MOA of quetiapine?
antagonizes dopamine and serotonin receptors
Side effects of quetiapine?
lens changes (PINE is difficult to see up high)
leukopenia
MOA of ziprasidone?
antagonizes dopamine and serotonin receptors; inhibits reuptake
Side effects of ziprasidone?
dysrhythmias and QT prolongations
(do not give to heart disease patients)
MOA of aripiprazole?
partial dopamine agonist
Side effects of aripiprazole?
increased risk of suicide
What are cautions for atypical drugs?
do not give to dementia-related psychosis
What are first generations psychosis drugs?
haloperidol
What are atypical (2nd and 3rd) generation psychosis drugs?
aripiprazole
risperidone
quetiapine
ziprasidone
