Psychosocial aspects of care and experiences of using pharmacies Flashcards Preview

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Flashcards in Psychosocial aspects of care and experiences of using pharmacies Deck (14)
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1

What is the main-stay of treatment for drugs that don't have physical withdrawal syndromes?

Psychosocial therapy

 

This could be simple (MI) to complex (CBT) interventions 

2

What is Intersectional Stigma?

When stigmas come together and become compounded...such as stigmas from pharmacy staff, themselves and the media all coming together

3

In terms of Brief Advice, what does the acronym 'FRAMES' stand for?

Feedback --> On the patients risk

Responsibility --> Explain that the patient is responsible for their health

Advice --> About reduction and the harms

Menu --> Give options

Empathy --> Don't stigmatise

Self Efficacy --> Encourage optimism

4

What is the major issue with non-opitate addicitons in terms of drug treatment?

There often isnt a pharmacological option!

 

When there is it is often very risky...like using benzos....so not worth the risk:benefit --> Only really used in alcohol detox

5

What is Acamprosate?

A drug that reduces the urge to drink

 

Used in alcohol relapse prevention.....although it isn't very effective

6

Can Cannabis cause a withdrawal syndrome?

No!

 

There is no physical dependence...only psychological

7

Why is adjunct therapy useful in the treatment of non-opitate addiction?

As often there is an underlying cause to the drug use, like insomnia or depression, so treating this with short course benzos, or antidepressents, may reduce the illicit drug use

8

What is Dual Diagnosis?

The term that is used when a patient has diagnosed mental health issues whilst also being being an addict

 

Ideally therefore, you want to treat both together.....but can cause some issues as mental health teams may think that the drugs are causing the mental health problems so don't think it's their problem

Can be a bit of a 'chicken or the egg' scenario

9

Explain the properties of Buprenorphine

Mu opioid partial agonist

Kappa antagonist

ORL-1/NOP agonist

 

Long duration of effect

10

What is the role of the kappa receptor in terms of anti-depressing effects?

Stress upregultes CREB, causing dynorphin (a kappa agonist) release

 

Kappa agonist binding prevents dopamine release...therefore causing a depressing effect

 

Therefore kappa antagonists have anti-depressing effects

11

What is Kappa System Overdrive?

Due to mu and kappa levels normally being in equalibrium, if a addict takes heroin consistently there will be a surge in mu activation

If this is stopped then it will cause a drop in mu activation and thus a sruge in kappa activation (which is depressing)

 

A kappa antagonist would prevent this from occuring

12

What is the ORL-1/NOP Receptor?

A member of the opioid receptor family, but opioids don't bind or activate them

 

Their endogenous ligands are Noiciceptin and Orphanin FQ....but these still don't active them!

 

Buprenorphine appears to bind to it

 

Activation of ORL-1/NOP appears to decrease analgesia, but is helpful in alcohol addiction

13

What is the biggest problem with the combination of buprenorphine/naltrexone?

Buprenorphine isnt orally active

 

Naltrexone isnt active sublingually

14

What is BU10119?

Kappa antagonist

Mu antagonist

NOP partial agonist

 

Has shown to give anti-depressing effects and inhibit drug/stress related relapse to drug taking