Psychosocial aspects of care and experiences of using pharmacies Flashcards Preview

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Flashcards in Psychosocial aspects of care and experiences of using pharmacies Deck (14)
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What is the main-stay of treatment for drugs that don't have physical withdrawal syndromes?

Psychosocial therapy


This could be simple (MI) to complex (CBT) interventions 


What is Intersectional Stigma?

When stigmas come together and become compounded...such as stigmas from pharmacy staff, themselves and the media all coming together


In terms of Brief Advice, what does the acronym 'FRAMES' stand for?

Feedback --> On the patients risk

Responsibility --> Explain that the patient is responsible for their health

Advice --> About reduction and the harms

Menu --> Give options

Empathy --> Don't stigmatise

Self Efficacy --> Encourage optimism


What is the major issue with non-opitate addicitons in terms of drug treatment?

There often isnt a pharmacological option!


When there is it is often very using not worth the risk:benefit --> Only really used in alcohol detox


What is Acamprosate?

A drug that reduces the urge to drink


Used in alcohol relapse prevention.....although it isn't very effective


Can Cannabis cause a withdrawal syndrome?



There is no physical dependence...only psychological


Why is adjunct therapy useful in the treatment of non-opitate addiction?

As often there is an underlying cause to the drug use, like insomnia or depression, so treating this with short course benzos, or antidepressents, may reduce the illicit drug use


What is Dual Diagnosis?

The term that is used when a patient has diagnosed mental health issues whilst also being being an addict


Ideally therefore, you want to treat both together.....but can cause some issues as mental health teams may think that the drugs are causing the mental health problems so don't think it's their problem

Can be a bit of a 'chicken or the egg' scenario


Explain the properties of Buprenorphine

Mu opioid partial agonist

Kappa antagonist

ORL-1/NOP agonist


Long duration of effect


What is the role of the kappa receptor in terms of anti-depressing effects?

Stress upregultes CREB, causing dynorphin (a kappa agonist) release


Kappa agonist binding prevents dopamine release...therefore causing a depressing effect


Therefore kappa antagonists have anti-depressing effects


What is Kappa System Overdrive?

Due to mu and kappa levels normally being in equalibrium, if a addict takes heroin consistently there will be a surge in mu activation

If this is stopped then it will cause a drop in mu activation and thus a sruge in kappa activation (which is depressing)


A kappa antagonist would prevent this from occuring


What is the ORL-1/NOP Receptor?

A member of the opioid receptor family, but opioids don't bind or activate them


Their endogenous ligands are Noiciceptin and Orphanin FQ....but these still don't active them!


Buprenorphine appears to bind to it


Activation of ORL-1/NOP appears to decrease analgesia, but is helpful in alcohol addiction


What is the biggest problem with the combination of buprenorphine/naltrexone?

Buprenorphine isnt orally active


Naltrexone isnt active sublingually


What is BU10119?

Kappa antagonist

Mu antagonist

NOP partial agonist


Has shown to give anti-depressing effects and inhibit drug/stress related relapse to drug taking