psychotic d/o Flashcards

(99 cards)

1
Q

alogia

A

poverty of speech

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2
Q

avolotion

A

inability to initiate and persist life activities

SCHIZOPHRENIA

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3
Q

mood in MDD v psychotic

A
MDD = mood congruent sx
psychotic = not so much
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4
Q

dopamine hypothesis of schizo

A

too much - basal ganglia

too little - prefrontal cortex

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5
Q

dopamine in schizo:

mesocortical

A

negative, cognitive, mood

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6
Q

dopamine in schizo:

tuberoinfundibular

A

inhibits prolactin release

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7
Q

dopamine in schizo:

mesolimbic

A

positive sx d/t hyperactivity

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8
Q

dopamine in schizo:

nigrostriatal

A

extrapyrimidal (tardive dyskinesia)

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9
Q

glutamate in schizo

A

insufficient signaling leads to positive and negative sx

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10
Q

glutamate in schizo

frontal cortex

A

since glutamate amplifies dopa, too little glutamate produces sx similar to having too little dopa

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11
Q

glutamate in schizo

basal ganglia

A

? but same as if too much dopa

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12
Q

PCP/NMDA model of schizo

A

PCP blocks NMDA receptors

  • causes schizo-like sx
  • maybe endogenous NMDA blocks cause schizo

Note: NMDA is a glutamate receptor

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13
Q

Glycine transport inhibitor and schizo

A

Normally glycine transporters protect NMDA from high levels of glycines
-inhibiting these transporters removes the protection

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14
Q

Chromosome involved in schizo

A

6

-specifically component 4 which controls Ca channel, glutamate signaling

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15
Q

extremely negativism

A

movement resistance

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16
Q

catalepsy

A

waxy

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17
Q

pruning

A

normal in kids, in schizo may keep going in adulthood

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18
Q

random things that might increase risk of schizo

A
  • birth trauma brain damage
  • viral infection 2 and 3 trimester
  • nutritional issues
  • maternal stress
  • parent dies in childhood
  • low SES
  • urban area, northern hemisphere, winter birth month
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19
Q

stages of schizo

A

prodrome (negative)
acute (positive)
recovery/residual

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20
Q

prognosis stats for schizo

A

30% functional
30% intermittent hospitalization
30% incapacitated
10% suicide

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21
Q

better prognostic factors for schizo

A
late onset
sudden onset
female
more positive sx 
higher baseline level of function
paranoid subtype (as opposed to disorganzied)
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22
Q

side effects of typical antipsychotics

A
high potency:
extrapyramidal
prolactin
sedation, wt gain (anti H1)
blurry vision, drymouth, conspitation, urinary retention, memory probs (anti M1)

low potency:
arrhythmia, skin discoloration, seizure

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23
Q

low potency and high potency example

A

high - haloperidol

low - chlorpromazine

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24
Q

extrapyramidal

A

dystonia
akathisia (rocking, pacing, mvmt compul)
parkinsonism
tardive dyskinseia

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25
torticollis
dystonia where your neck is bent to one side
26
opisthotonos
arched back like in tetanus
27
side effects of atypical antipsychotics
``` wt gain increased blood glucose increased triglycerides possible sedation prolonged QT ```
28
brief psychotic episode
like schizo but lasts 1d-1mo | - increased risk if woman, personality d/o
29
schizophreniform
like schizo but 1mo-6mo
30
delusion d/o
delusions lasting >1 mo rare hallucinations functioning unaffected no disorganized thought/behavior
31
schizoaffective
``` schizo sx + mood psychotic sx in absence of mood sx psychotic sx last 2 weeks or more prognosis slightly better more common in women ```
32
schizoid
detached from social relationships restricted emotion in social settings (nothing psycho)
33
schizotypal
v uncomfortable w close relationships maybe cognitive distortions maybe eccentric behavior (nothing psycho)
34
cognitive probs in psychosis
working mem executive functioning attention learning
35
appraisal and anticipation (anxiety)
appraisal in cortex parietal - threatening? frontal - what do i do? anticipation deeper structure, fight/flight
36
arousal (anxiety)
NE, sympathetic
37
Panic d/o
fear of panic attack itself | misinterpet things - i'm dying
38
Social phobia
6+ mo negative expectations negative interpretation of others' response
39
PTSD
memory overestimation of risk will recur nightmare
40
normal stress response path
``` hypothalamus pituitary adrenal cortex cortisol > negative feedback ```
41
GAD
6+ months, 3/6 criteria | restless, fatigue, conc, irritable, muscle tense, sleep disturbed
42
agoraphobia
fear 2+ | open space, enclosed space, in line/crowd, outside your home alone
43
panic attack (d/o is repeated attacks)
4+ of the following racing heart, sweat, trembling, SOB, choking, angina, nausea, dizzy, chills, tingling, derealization/depersonalization, fear of going crazy, fear of dying d/o = 1 mo worrying you'll have another
44
Simple phobia
6+ mo
45
arousal examples
panic, tonic, flushing, tension, HA
46
GAD epi
females, 30+ | 4-7% of population
47
simple phobia epi
females, 12% | usually resolves by adulthood
48
social phobia epi
male = female, onset <25 | 3-5% pop
49
panic epi
females, <30
50
3 CBT approaches for anxiety
exposure systematic desensitization (close eyes) flooding
51
deep breathing explanation for anxiety tx
shallow breathing = more CO2, brain thinks it's suffocating | deep breathing = more O2, stops this response
52
central neurotransmitters (2)
gaba, glutamate
53
monoamine (2)
seratonin, NE "fight/flight"
54
MAPPSS-CO
``` mood anxiety psychotic personality substance somatic cognitive obsessions ```
55
1 in _ teens have d/o
5
56
Suicide is __ cause of death overall | __ cause of death 10-34
10, 2
57
3 techniques ending in -ation for a psych interview
normalization continuation redirection
58
4 Ps
predisposing precipitating perpetuating protective
59
stereotypy
repetition of senseless speech or movement (autism, schizo)
60
catatonia
immobile/weird positioning
61
dystonia
painful involuntary muscle contractions
62
dyskinesia
difficulty performing voluntary movements
63
circumstantiality
include too many details
64
derailment
sentences don't make sense
65
flight of ideas
move rapidly from idea to idea
66
neologism
new words or using words differently
67
distractable though
during discussion, pt changes course due to something unrelated in the environment
68
word salad
literally makes no sense, just random words
69
tangentality
you give an appropriate response to the question but don't answer the question
70
alogia, preoccupation, delusion | circumstantiality are disorders of
thought content
71
ideas of influence
another person/force is controlling one's behavior
72
nihilistic
think self, part of self, world does not exist
73
jealousy
everyone wants what they have
74
attention
WORLD backwards
75
concentration
serial 7s
76
calculation
serial 7s (also assess concentration)
77
interlocking pentagons difficulty
constructional apraxia
78
SIGECAPS
``` sleep interest guilt energy concentration appetite psychomotor suicide ```
79
brain structure hyperactive in dpn
hypothalamus-pituitary-adrenal axis
80
monoamine in neocortex
concentration
81
monoamine in striatum
sluggish movement
82
monoamine in amygaloid body
anxiety
83
monoamine in hypothalamus
sleep and appetite
84
monoamine in hippocampus
memory problems
85
manic episode
1 week | significant impairment in functioning
86
hypomanic
4 days or less | not significant impairment in functioning
87
disruptive mood d/o tx
CBT
88
disruptive mood d/o
sx began at age 10 or before dx can only be made from 6-18 sx last 12+ mo
89
persistant depressive d/o
2 years
90
psychotic features in depressive are mood ___
congruent
91
ecstasy - appearance
euphora, diminished fear, self-confident
92
ecstasy - mechanism
release monoamines
93
hallucinogens - appearance
dilated pupils, synesthesia - LSD, hallucinations - mescaline, visual geometricization
94
hallucinogens - mechanism
seratonin agonist
95
PCP - appearance
``` Rage Erythema Dialated pupils Delusions Amnesia Nystagmus Excitation Skin dryness ```
96
PCP - side effects
memory loss, liver probs, dpn, psychosis
97
PCP - mechanism
NMDA antagonist, hallucinations
98
cannabis - mechanism
GPCR receptor for THC, inhibits cAMP in hippocapmus, basal ganglia, cerebellum
99
cannibis - appearance
perceptual disturbance, anxiety, paranoia, infection, tachycadic, dry mouth, increased appetite