psychotic d/o Flashcards
(99 cards)
alogia
poverty of speech
avolotion
inability to initiate and persist life activities
SCHIZOPHRENIA
mood in MDD v psychotic
MDD = mood congruent sx psychotic = not so much
dopamine hypothesis of schizo
too much - basal ganglia
too little - prefrontal cortex
dopamine in schizo:
mesocortical
negative, cognitive, mood
dopamine in schizo:
tuberoinfundibular
inhibits prolactin release
dopamine in schizo:
mesolimbic
positive sx d/t hyperactivity
dopamine in schizo:
nigrostriatal
extrapyrimidal (tardive dyskinesia)
glutamate in schizo
insufficient signaling leads to positive and negative sx
glutamate in schizo
frontal cortex
since glutamate amplifies dopa, too little glutamate produces sx similar to having too little dopa
glutamate in schizo
basal ganglia
? but same as if too much dopa
PCP/NMDA model of schizo
PCP blocks NMDA receptors
- causes schizo-like sx
- maybe endogenous NMDA blocks cause schizo
Note: NMDA is a glutamate receptor
Glycine transport inhibitor and schizo
Normally glycine transporters protect NMDA from high levels of glycines
-inhibiting these transporters removes the protection
Chromosome involved in schizo
6
-specifically component 4 which controls Ca channel, glutamate signaling
extremely negativism
movement resistance
catalepsy
waxy
pruning
normal in kids, in schizo may keep going in adulthood
random things that might increase risk of schizo
- birth trauma brain damage
- viral infection 2 and 3 trimester
- nutritional issues
- maternal stress
- parent dies in childhood
- low SES
- urban area, northern hemisphere, winter birth month
stages of schizo
prodrome (negative)
acute (positive)
recovery/residual
prognosis stats for schizo
30% functional
30% intermittent hospitalization
30% incapacitated
10% suicide
better prognostic factors for schizo
late onset sudden onset female more positive sx higher baseline level of function paranoid subtype (as opposed to disorganzied)
side effects of typical antipsychotics
high potency: extrapyramidal prolactin sedation, wt gain (anti H1) blurry vision, drymouth, conspitation, urinary retention, memory probs (anti M1)
low potency:
arrhythmia, skin discoloration, seizure
low potency and high potency example
high - haloperidol
low - chlorpromazine
extrapyramidal
dystonia
akathisia (rocking, pacing, mvmt compul)
parkinsonism
tardive dyskinseia