Psychotropic Formulations Flashcards
(12 cards)
Parenteral administration
Oil solutions
Oil suspensions
Oil solutions
Drug is completely dissolved in oily solvent
Partition into the surrounding aqueous medicum to be absorbed
Short onset - one process
Oil suspensions
Drug exists in two forms, dissolved (molecular dipsersion) and undissolved (coarse dispersion)
Undissolved particles acting as a drug reservoir.
Drug particles must first dissolve and then partition into the surrounding aqueous medium
Long duration - two process
Longer fatty acid chain
Increase lipophilicity
Oral formulations
Controlled-release
Controlled-release (CR): Paroxetine
One layer consists of the degradable barrier layer, the other contains the active material in a hydrophilic matrix
Enteric coat delays the start of drug release
Individual dose needs to be about 25% higher than the IR to received equivalent dosing - 80% is released, 20% is retained
Osmotic controlled release oral delivery system (OROS)
Deliver pharmacotherapy OD
Based on osmotic pump
OROS: Methylphenidate HCl
Three compartments - low concentration of drug, high concentration of drug, contains water reactive molecules
Overcoat dissolves, water is absorbed
Push compartment expands, released drug from the first compartment at a controlled rate, drug release begins from second compartment at a different rate
Fast-dissolving . disintegrating tablets (FDDTs)
Disintegrate and / or dissolve rapidly in the saliva without the need for water
Transdermal drug delivery
Matrix system
Reservoir system
Matrix system
Three-layer system - backing film, drug-containing adhesive layer, protective film
Integrity is maintained even if the system is cut - less potential for dose dumping
Thinner and may be easier to use
Reservoir system
Five layer system - backing film, drug reservoir, release membrane, adhesive film, protective film
Integrity is not maintained if cut or tampered - potential for dose dumping
