Pulmonary Hypertension Flashcards

(34 cards)

1
Q

What is pulmonary hypertension?

A

It is defined as an increased blood pressure within the pulmonary arteries, specifically a mean arterial pressure greater than 25mmHg at rest

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2
Q

What is the pathophysiological result of pulmonary hypertension?

A

This increased pressure in the pulmonary arteries results in an increased strain on the right side of the heart and a back pressure of blood into the systemic venous system

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3
Q

What are the two classifications of pulmonary hypertension?

A

Primary Pulmonary Hypertension

Secondary Pulmonary Hypertension

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4
Q

What is primary pulmonary hypertension?

A

It is defined as pulmonary hypertension which is not related to an underlying cause

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5
Q

What is secondary pulmonary hypertension?

A

It is defined as pulmonary hypertension due to an underlying condition

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6
Q

What is the subclassifications of secondary pulmonary hypertension based on?

A

The specific underlying aetiology

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7
Q

What is group one secondary pulmonary hypertension?

A

Pulmonary hypertension related to connective tissue disease

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8
Q

What connective tissue disease is associated with pulmonary hypertension?

A

SLE

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9
Q

What is group two secondary pulmonary hypertension?

A

Pulmonary hypertension related to left heart disease

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10
Q

What is group three secondary pulmonary hypertension?

A

Pulmonary hypertension related to chronic lung disease

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11
Q

What three chronic lung diseases are associated with pulmonary hypertension?

A

COPD

Interstitial lung disease

Obstructive sleep apnoea

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12
Q

What is group four secondary pulmonary hypertension?

A

Pulmonary vascular disease

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13
Q

What pulmonary vascular disease is associated with pulmonary hypertension?

A

Pulmonary embolism

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14
Q

What is group five secondary pulmonary hypertension?

A

Pulmonary hypertension related to miscellaneous conditions

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15
Q

What three miscellaneous conditions are associated with pulmonary hypertension?

A

Sarcoidosis

Glycogen storage disorder

Haematological disorders

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16
Q

What ten clinical features are associated with pulmonary hypertension?

A

Dyspnoea

Syncope

Chest Pain

Peripheral Oedema

Tachycardia

Loud Pulmonary Component of S2

Third Heart Sound

Parasternal Heave

Increased JVP

Hepatomegaly

17
Q

What is the main presenting clinical feature of pulmonary hypertension?

18
Q

What are the clinical features of pulmonary hypertension related to?

A

The gradually worsening right ventricular function

19
Q

What four investigations are used to diagnose pulmonary hypertension?

A

ECG Scan

Chest X-Ray (CXR)

Echocardiogram Scan

Right Heart Catheterisation

20
Q

What is the first line investigation used to diagnose pulmonary hypertension? Why? However, what is important to remember?

A

ECG scan

It is a quick bedside investigation that can be conducted

It doesn’t provide a definitive diagnosis of pulmonary hypertension. In addition, normal results don’t exclude a diagnosis

21
Q

In general, how does pulmonary hypertension present on an ECG scan?

A

There are features of right ventricular strain

22
Q

What are the four signs of pulmonary hypertension on ECG scans?

A

Peaked R Waves in V1 – V3

Peaked S Waves in V4 – V6

Right Axis Deviation

Right Bundle Branch Block

23
Q

What do peaked R and S waves indicate on an ECG scan?

A

Right ventricular hypertrophy

24
Q

What are the two signs of pulmonary hypertension on CXR?

A

Dilated Pulmonary Arteries

Right Ventricular Hypertrophy

25
What investigation is used to provide a definitive diagnosis of pulmonary hypertension?
ECHO scan
26
How are ECHO scans used to diagnose pulmonary hypertension?
They allow an estimated pulmonary arterial pressure to be obtained
27
What other investigation is used to provide a definitive diagnosis of pulmonary hypertension?
Right heart catheterisation
28
How is right heart catheterisation conducted?
It involves the insertion of a catheter into the pulmonary artery
29
How are right heart catheterisations used to diagnose pulmonary hypertension?
They allow an estimated pulmonary arterial pressure to be obtained
30
In what four ways do we manage primary pulmonary hypertension?
IV Prostanoids Endothelin Receptor Antagonists Phosphodiesterase Inhibitors Cardiopulmonary Transplant
31
Name a prostanoid used to manage primary pulmonary hypertension
Epoprostenol
32
Name two endothelia receptor antagonists used to manage primary pulmonary hypertension
Bosentan Macitentan
33
Name a phosphodiesterase inhibitor used to manage primary pulmonary hypertension
Sildenafil
34
How is secondary pulmonary hypertension managed?
We treat the underlying cause