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Pulmonary > Pulmonary Infection Pharmacology > Flashcards

Pulmonary Infection Pharmacology Flashcards

1
Q

Legionnaires treatment

A

Azithro or clarithromycin sceond levo or ciprofloxacin

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2
Q

Outpatient no modifying factors pneumonia treatment

A

Macrolide or doxycycline

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3
Q

Outpatient with COPD with steroids or antibiotics last 3 mo

A

Fluoroquinilone or amox/clav or clarithromycin plus cephalosporin

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4
Q

Outpatient with COPD without steroids or antibiotics in last 3 mo

A

Clarithromycin or doxycyclin

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5
Q

Nursing home pneumonia treatment

A

Fluoroquinilone or amox/clav or clarithromycin plus cephalosporin

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6
Q

Hospital ward pneumonia treatment

A

Fluoroquinilone or amox/clav or clarithromycin/azithromycin plus cephalosporin

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7
Q

ICU pneumonia treatment

A

3rd gen cephalosporin plus macrolide or pip/taz or fluoroquinilone (if P aeruginosa then cipro plus ceftazidime, meropenem, or pip/taz; macrolide plus aminoglycoside, cefepime, ceftazidime, meropenem, or pip/taz)

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8
Q

Macrolides MOA

A

Inhibit 50s ribosome blocking translocation

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9
Q

Tetracyclines and Aminoglycosides MOA

A

Inhibit 30s ribosome blocking protein synthesis

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10
Q

Fluoroquinilone MOA

A

DNA gyrase inhibitor

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11
Q

Penicillin, Cephelosporin, and Carbopenem MOAs

A

Cell wall synthesis inhibitor

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12
Q

Gram- treatment for nosocomial

A

Imipinem/Cilastin, Aztreonam, Ceftazidime, Vancomycin

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13
Q

Aspiration pneumonia treatment (anaerobes and G-)

A

Clindamycin or Amoxicillin/Sulbactam

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14
Q

Antibiotics that dont need adjustment with renal failure

A

Linezolid, Erythromycin, Azithromycin,Doxycycline, Ceftriaxone, Clindamycin

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15
Q

Macrolide adverse reactions

A

Increased QT and cholestatic jaundice (E-CYP3a4 inhibitor and pgp)

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16
Q

Tetracycline adverse reactions

A

Photosensitivity, tooth discoloration, dec bone growth

17
Q

Carbopenem adverse reactions

A

Seizures

18
Q

Gentamicin

A

Nephro and ototoxicity

19
Q

Fluoroquinilone adverse reactions

A

Tendon rupture

20
Q

Vancomycin adverse reactions

A

Nephro and ototoxicity; red man syndrome

21
Q

What drug is inhibited by surfactant

A

Daptomycin

22
Q

Bronchitis treatment

A

Amox/clav, azithromycin, clarithromycin, doxycycline (if severe); if resistant then ciprofloxacin

23
Q

Lung abscess treatment (anaerobes + CAP; anaerobes- nosocomial)

A

Clindamycin; for nosocomial metronidazole plus ceftriaxone

Pulmonary (6 decks)

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