Pumps #2 Flashcards Preview

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Flashcards in Pumps #2 Deck (12)
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1
Q

Structure of P-type ATPases - Region B

A

induces conformational changes in ion binding site

2
Q

Structure of P-type ATPases - Region C

A

phosphorylation site and nucleotide binding site

3
Q

Structure of P-type ATPases - Region J

A

comprises a hinge to allow cytosolic regions to move and interact

4
Q

CPx pumps

A

~ transport toxic and nutrient metals

~ found in animals, plants, fungi and bacteria

5
Q

Menkes disease

A

systemic copper deficiency

6
Q

Wilsons disease

A

excessive copper accumulation in the liver

7
Q

V-type pump - structure/function

A

~ Multiple transmembrane and cytosolic subunits

~ Establishes H+ electrochemical gradients.

8
Q

V-type pump - location

A

vacuolar
lysosome
synaptic vesicles

9
Q

ABC-type pump - structure/function

A

~ 2 sections of transmembrane spanning domains
~ 2 ATP binding domains
~ Range of physiological functions

10
Q

ABC-type pump - location

A

all membrane types

11
Q

ABC meaning

A

ATP Binding Cassette

12
Q

P-type pump - location

A

PM, SR or ER