Q1 Psychopharmacology Flashcards
(43 cards)
what is an important determinant of the uptake of a drug in the brain
- its lipid solubility
what increases permeability of the BBB
- meningeal and encephalic inflammation
most psych meds are oral so absorption occurs where
- small intestine
it takes how many half lives to reach steady state
- 3-5
which type of drugs enact their effects immediately
- stimulants
where is serotonin made
- raphe nuclei
where is NE made
- locus coeruleus
90% of all serotonin and receptors are found where
makes sense why SSRIs cause
role of it there
- in the Gut
- GI upset
- motility of gastric and intestinal smooth muscle
in the spinal cord, serotonin is _____ in pain pathways
- inhibitory
serotonin is also associated with which psychological condition
- anxiety
what was serotonin originally named
- enteramine
platelets require serotonin for what
which means SSRIs have a risk of
- aggregation
- upper GI bleeding (epistaxis)
spontaneous clonus, tremor and hyperreflexia, hypertonia and inducible or ocular clonus with agitation or diaphoresis are symptoms of
- serotonin syndrome
NE regulates _____ and ______
- blood pressure
- calmness
for the purposes of pharmacology, we focus on which subtypes of NE adrenergic receptors
- alpha
dopamine is usually (excitatory/inhibitory)
- inhibitory
dopamine GI action
dopamine antagonist result
- pro-motility
- constipation
Monoamine known to be involved in parkinsonism, mood, fear, pleasure, addiction (opioid), and schizophrenia
- dopamine
what are the building blocks of dopamine
- phenylalanine and tyrosine
is dopamine able to cross the BBB
why
- no
- it is not lipophilic
which projection are important for higher-order cognitive function, including motivation, reward, emotion, and impulse control
- mesocortical
which pathway is associated with reward, and learned behaviors. Dysfunction in this pathway is associated with addiction, schizophrenia, and psychosis and learning deficits
- mesolimbic
which pathway is a key regulator of movement. impairments in this pathway are involved in Parkinson’s and underlie motor adverse effects associated with antipsychotics like pseudoparkinsons
- nigrostriatal
dopamine released in the _______ pathway is sent to the pituitary where it regulates _____ secretion
- tuberoinfundibulnar
- prolactin
