Quality Control 1 and 2 (PACOP Green) Flashcards
(300 cards)
1
Q
A buret with a glass stopcock can be used for:
a. Alcohols
b. Bases
c. Acids
d. Salts
A
c. Acids
2
Q
The operation speed for paddle in a dissolution apparatus is:
a. 150 rpm
b. 200 rpm
c. 100 rpm
d. 50 rpm
A
d. 50 rpm
3
Q
Radiant energy refers to:
a. Visible
b. IR
c. UV
d. All of the above
A
d. All of the above
4
Q
High pressure liquid chromatography method of analysis is more advantageous than the other column chromatography as to:
a. Ease to operate
b. Greater speed
c. More precise
d. All of the above
A
d. All of the above
5
Q
Content uniformity test is to be performed for all tablet products whose active ingredient is:
a. 50 mg or smaller
b. 324 mg or more
c. 130-324 mg
d. 130 mg or less
A
a. 50 mg or smaller
6
Q
The statement of expiration date assures the patient:
a. Absence of toxicity
b. Full therapeutic efficacy
c. Complete absorption of drug
d. Absence of interaction
A
b. Full therapeutic efficacy
7
Q
A factor obtained by taking the ratio of the actual normality to the theoretical normality is:
a. Titer
b. Normality factor
c. Flame photometer
d. Polarimeter
A
b. Normality factor
8
Q
To measure the optical activity of a sample, the instrument used is:
a. Spectrometer
b. Refractometer
c. Flame photometer
d. Polarimeter
A
d. Polarimeter
9
Q
- In phenol content determination of a volatile oil, the layer in the graduated neck of the cassia flask read 2.7 mL obtained from a sample of 10 mL of the oil after treatment of KOH. The % phenol is:
a. 69.8
b. 27.0
c. 73.0
d. 7.30
A
c. 73.0
10
Q
- Using the Karl Fischer method, determine the moisture content of a sample of raw material where a 63 mg sample consumed 0.75 mL of titrant. Water equivalence factor is 1.10
a. 1.8%
b. 1.3%
c. 2.10%
d. 0.74%
A
B. 1.3%
11
Q
During shipment of the finished product to the wholesale or retail outlets, the responsible person should ensure:
a. Product identification
b. No damage, spillage, or breakage
c. Segregation of different types
d. All of the above
A
d. All of the above
12
Q
To find the mEq factor of an oxidizing agent is to divide the molecular weight by:
a. Valence
b. No. of electron lost
c. No. of electrons gained (VDGEROA)
d. Replaceable hydrogen
A
c. No. of electrons gained (VDGEROA)
13
Q
Lower control limit if mean is 10.5 mL and one standard deviation is 0.025
a. 10.450 mL
b. 10.420 mL
c. 10.575 mL
d. 10.425 mL
A
d. 10.425 mL
14
Q
Gas chromatography is utilized in the separation and identification of:
a. Amino acid
b. Alkaloids
c. Volatile liquids in a mixture
d. Blood components
A
c. Volatile liquids in a mixture
15
Q
The name of the originator of using silver nitrate as the titrant and potassium chromate as the indicator in volumetric precipitation of chloride
a. Volhard
b. Beer
c. Mohr
d. Fajan
A
c. Mohr
16
Q
Reassay date of thiamine HCl if tested in December 1992
a. 6/93
b. 12/93
c. 12/94
d. 6/94
A
b. 12/93
17
Q
Find the acid number of a raw material a mole weighing 1.230 g which required 30 mL of 0.1100 N NaOH to bring out the end point using alcoholic KOH in the titration
a. 150.54 mg/g
b. 157.72 mg/g
c. 109.18 mg/g
d. 124.41 mg/g
A
a. 150.54 mg/g
18
Q
A critical defect that would stop the packaging operation is:
a. Misaligned label
b. Wrong label
c. Smeared label
d. Inverted label
A
b. Wrong label
19
Q
An instrument used to measure the durability of tables to shipping/transportation against shock and abrasion
a. Metal detector
b. Top loading balance
c. Friabilator
d. Colorimeter
A
c. Friabilator
20
Q
Methods of microbial assay of antibiotics
a. Turbidimetric
b. Cylinder plate
c. Both A and B
d. None of the above
A
a. Turbidimetric
21
Q
Retention or preservation of samples and records of all pharmaceutical products should be monitored for signs of deterioration. The length of time they should be stored is:
a. 2 years after date of expiration
b. 1 year after date of expiration
c. 2 years
d. 3 years
A
b. 1 year after date of expiration
22
Q
Potentiometry finds application in:
a. Biological assay
b. Identification test
c. Qualitative analysis
d. pH determination
A
d. pH determination
23
Q
In the assay of sulfonamides, the method used is
a. Diazotization
b. Acid-base titration
c. Gravimetric
d. Volumetric
A
a. Diazotization
24
Q
A term in compleximetry used to indicate a determination of a metal in the presence of another metal
a. Linking
b. Masking
c. Complexing
d. Redox
A
b. Masking
25
cGMP is:
a. An agency created by RA 3720
b. Also known as food, drug, and cosmetic act
c. Both A and B are correct
d. Both A and B are incorrect
d. Both A and B are incorrect
26
The sampling and examination of all raw materials received by the factory is a function of the:
a. Documentation
b. Biological testing laboratory
c. Material inspection
d. Analytical laboratory
d. Analytical laboratory
27
The indicator for EDTA direct titration against CaCO3 is:
a. Methyl red
b. Hydroxynaphthol blue
c. Methylene blue
D. Thymol blue
b. Hydroxynaphthol blue
28
Safety or toxicity for infusion plastic sets is conducted using:
a. Dogs
b. Food ingestion
c. White mice
d. Rabbits
c. White mice
29
Chemical analysis which determines the amount of percentage content in which the component of a substance is present:
a. Quantitative
b. Proximate
c. Qualitative
d. Ultimate
a. Quantitative
30
The addition of overage is justified when:
a. The clinical studies show that the overage is safe therapeutically
b. The unstable active ingredients cannot be possibly standardized
c. Both statements are correct
d. Both statements are incorrect
c. Both statements are correct
31
The period of stability of a preparation is the time from the date of manufacture of the formulation until its chemical or biological activity is not less than _____ of the labeled potency
a. 99%
b. 93%
c. 90%
d. 95%
c. 90%
32
Adsorbents used in TLC:
a. Silica gel and aluminum dioxide
b. Aluminum oxide
c. Silica gel
d. Kieselguhr
a. Silica gel and aluminum oxide
33
Content uniformity test is conducted in:
a. 5 tablets
b. 20 tablets
c. 10 tablets
d. 15 tablets
c. 10 tablets
34
The most effective manner to clean glass apparatus is:
a. Soaking in detergent
b. Treatment with chromic acid
c. Rinsing with alcohol
d. Rinsing with nitric acid
B. Treatment with chromic acid
35
Ferrous sulfate is:
a. Agent that loses electron
b. An oxidizing agent
c. Reducing agent
d. Both A and C
c. Reducing agent
36
A test which is determined by selecting not less than 30 tablets from each production batch and assaying 10 tablets individually as directed in the assay of the individual compedial monograph
a. Content uniformity
b. Weight variation
c. Disintegration test
d. Dissolution test
a. Content uniformity
37
These are instruments under spectrometric methods which operate based on the absorption or emission of electromagnetic radiation as a result of its interaction with matter, EXCEPT:
a. Potentiometer
b. NMR
c. X-ray
d. IR
a. Potentiometer
38
The ash content of an organic compound is an impurity of:
a. Inorganic matter
b. Carbon
c. Gas
d. Volatile oil
a. Inorganic matter
39
Type of QC equipment used for measuring the absorbance of substances between regions 380-780 nm
a. UV/VIS spectrophotometer
b. Infrared spectrophotometer
c. Mass spectrophotometer
d. Colorimeter
a. UV/Vis spectrophotometer
40
Type of titration used in volumetric analysis:
a. Neutralization
b. Residual
c. Direct
d. Both B and C
a. Neutralization
41
The choice method of determining the alcohol content of pharmaceutical preparation:
a. Specific gravity
b. Percolation
c. Fractional distillation
d. Cryoscopic
a. Specific gravity
42
The gram molecular weight of sulfuric acid is 98. A solution containing 49 g/L of solution is:
a. 0.2 M
b. 0.5 N
c. 1 N
d. 1 M
c. 1 N
43
USP steroid identification test:
a. Gravimetric
b. Spectrophotometric
c. Fluoroscopic
d. Chromatographic
b. Spectrophotometric
44
Which of the following are principles of chromatographic separation?
I. Adsorption
II. Partition
III. Ion-exchange
IV. Molecular exclusion
a. I and II
b. I, II, and III
c. I, II, III, and IV
d. None of the above
c. I, II, III, and IV
45
Titer is an expression of concentration in terms of:
a. g/L
b. mg/L
c. g of solute/100 mL
d. g or mg/mL
b. mg/L
46
Titrating an alkaline sample with an acid standard solution is known as:
a. Direct alkalimetry
b. Gravimetric analysis
c. Precipitation method
d. Indirect alkalimetric
a. Direct alkalimetry
47
Retention or preservation of samples and records of all pharmaceutical products should be monitored for sign of deterioration. The length of time they should be stored is:
a. 2 years
b. 1 year after the expiry date of the product
c. 3 years
d. 2 years after the expiry date
b. 1 year after the expiry date of the product
48
LAL reagent is used to:
a. Measure pH of solution
b. Test the presence of pyrogens
c. Prevent the oxidation of parenteral prep
d. Acts as preservative for pharmaceutical
b. Test the presence of pyrogens
49
Control chart limit which alerts the operator to closely monitor the process:
a. Warning limit
b. Action limit
c. Acceptable limit
d. Any of these
c. Acceptable limit
50
In process inspection tests to be performed during the filling of parenteral products
a. Viscosity
b. Light inspection for clarity of solution
c. Fill volume
d. Light inspection and fill volume
d. Light inspection and fill volume
51
USP limit for tablet content uniformity
a. 90-110%
b. 90-100%
c. 95-110%
d. 85-115%
d. 85-115%
52
Analysis function would include:
a. Shelf-life studies
b. In-process control
c. Raw material control
d. All of these
d. All of these
53
In the SQC, the control chart prepared based on the number of fraction defective is called:
a. Attribute chart
b. Bar chart
c. Beer's plot
d. Variable chart
a. Attribute chart
54
The number of linear openings per square inch is known as:
a. Sieve
b. Mesh
c. Both A and B
d. None of these
b. Mesh
55
Test used to determine the strength of tablets include:
a. Content uniformity
b. Hardness
c. Weight variation
d. Both A and B
b. Hardness
56
Which of the given is the least used as sampled materials?
a. Final product
b. Records
c. Immediate product
d. Raw materials
b. Records
57
The presence of cotton fiber in a liquid preparation is considered a/an:
a. Critical defect
b. Variable defect
c. Internal defect
d. Ocular defect
d. Ocular defect
58
A special residual method in acidimetry intended for the determination of nitrogen content in organic compounds
a. Karl Fischer method
b. Back titration
c. Volhard method
d. Kjeldahl method
d. Kjeldahl methodAs
59
Assay of 250 mL solution of dopamine 200 mg injection resulted in the following data. Based on these, determine the amount of dopamine in 100 mL solution:
Sample volume - 5.0 mL
Solution volume - 250.0 mL
Absorbance sample - 38259
Absorbance standard - 20163
a. 0.04 mg/100 mL
b. 4.5 mg/100 mL
c. 3.8 mg/100 mL
d. 4.5 mg/100 mL
a. 0.04 mg/100 mL
60
The disintegration constant of a radioisotope is 0.0502 day. Calculate the half life of the radioisotope.
a. 11 days
b. 13 days
c. 15 days
d. 21 days
b. 13 days
61
Determine the distance traveled by the solute, if its Rf value is 0.688 and the solvent travels 8.0 cm. The sample weight is 1.02 mg.
a. 11.6 cm
b. 11.8 cm
c. 5.5 cm
d. 0.70 cm
c. 5.5 cm
62
One mole of dichromate ions gains a total of _____ electrons when converted to chromous ion
a. 3
b. 6
c. 10
d. None of the above
b. 6
63
Koetsdorfer number is a synonym for:
a. Ester value
b. Saponification value
c. Iodine value
d. Acetate value
b. Saponification value
64
The chemical constant used in the analysis of fats and oils are:
a. Iodine value
b. Saponification value
c. Acid value
d. All of the above
d. All of the above
65
Water content of raw materials is determined by quality control equipment, such as:
I. Ohaus moisture balance
II. Karl Fischer titrimetry
III. pH meter
IV. Vacuum oven
a. I, II and IV
b. II, III, and IV
c. I, II, and III
d. I, II, III, and IV
a. I, II, and IV
66
The primary standard used to standardize Karl Fischer reagent is:
a. Anhydrous sodium carbonate
b. Potassium biphthalate
c. Sodium tartrate
d. Sodium oxalate
c. Sodium tartrate
67
Plastic containers for ophthalmic or parenteral preparations are sterilized by:
a. Microwave
b. Autoclaving
c. Soaking in formalin
d. Ethylene oxide
d. Ethylene oxide
68
A sample is:
a. Is taken from a population
b. It should represent the whole batch from where it is taken
c. Is a finite number of objects selected from a population
d. All of the above
d. All of the above
69
Instrument to determine the tightness of a cap is:
a. Crimper
b. Torque tester
c. Resister
d. pH meter
b. Torque tester
70
Its primary objective is to monitor all features of a product
a. SOP
b. Sampling
c. Stability testing
d. IPQC
d. IPQC
71
It has a high degree of purity and is used in direct standardization purposes:
a. Technical grade
b. CP grade
c. Primary standard
d. Any of the above
d. Any of the above
72
The primary standard used for standardization of Ce(SO4)2 in cerimetric method of analysis is:
a. K2Cr2O7
b. As2O3
c. KMnO4
d. H2C2
b. As2O3
73
In paper partition chromatography, what is the Rf value of a compound if the solute travels 3.1 cm and the solvent moves 4.3 cm after 5 minutes?
a. 3.605
b. 0.721
c. 13.33
d. 1.387
b. 0.721
74
A sampling inspection in which decision is made to accept or to not accept an item:
a. Rejection number
b. Acceptance sampling
c. Acceptance number
d. Any of the above
b. Acceptance sampling
75
Indicators used for acid-base titration, EXCEPT:
a. Methyl red
b. Methyl orange
c. Phenolphthalein
d. Ferric alum
d. Ferric alum
76
Sample sizes of bottles to check for cap tightness
a. 10
b. 30
c. 20
d. 15
a. 10
77
Quantitative analysis of morphine
a. Ultimate analysis
b. Proximate assay
c. Ultimate assay
d. Proximate analysis
c. Ultimate assay
78
What is the normality of sulfuric acid containing 73.5 g/500 mL of solution?
a. 2.0 N
b. 2.5 N
c. 3.0 N
d. 1.0 N
c. 3.0 N
79
Three months of acceptable data at 37-40°C/75% RH can be extrapolated to _____ year/s expiry date
a. 1
b. 5
c. 4
d. 2
d. 2
80
The periodic examination on the quality of inventories is a function of:
a. Quality coordination office
b. Biological testing lab
c. Analytical lab
d. Material inspection section
d. Material inspection section
81
The spotting agent for amino acids in paper chromatography is:
a. Potassium chromate
b. Ninhydrin
c. Silver nitrate
d. Iodine
b. Ninhydrin
82
Negligible ash in a pharmaceutical preparation is:
a. 200 mg
b. 1000 mg
c. 500 mg
d. 500 mcg
d. 500 mcg
83
The reassay date of raw material is based on their:
a. Stability
b. Price
c. Quantity purchased
d. None of the above
a. Stability
84
Quality must be built into the product during:
a. Research
b. Development
c. Production
d. All of the above
d. All of the above
85
Recommended indicator in the assay of alkaloids:
a. Phenolphthalein
b. Methyl red
c. Methyl orange
d. Litmus paper
b. Methyl red
86
The titrant in no-aqueous alkalimetry is:
a. Ammonium hydroxide
b. Perchloric acid
c. Sodium methoxide
d. Sodium hydroxide
c. Sodium methoxide
87
Two substances reacting upon reaching the endpoint must have the same:
a. Number of equivalents
b. Volume
c. Normality
d. Weight
a. Number of equivalents
88
In radiopharmacy, REM means
a. Roentgen equivalent man
b. Radiation per millisecond
c. Radiation per minute
d. Roentgen exposure per minute
a. Roentgen equivalent man
89
One of the laws in spectrophotometry:
a. Law of mass action
b. Boyle's law
c. Newton's law
d. Beer's law
d. Beer's law
90
Substances that have the power of rotating the plane polarized light are said to be:
a. Light sensitive
b. Optically active
c. Active constituents
d. Dextrorotatory
b. Optically active
91
Nephelometry is based on the measurement of light that is:
a. Reflected
b. Transmitted
c. Absorbed
d. Adsorbed
a. Reflected
92
The process of determining the volume of standard solution required to react with a known amount of substance being assayed
a. Neutralization
b. Titration
c. Oxidation
d. Hydrolysis
b. Titration
93
Color of phenolphthalein in caustic potash
a. Pink
b. Yellow
c. Colorless
d. Orange
a. Pink
94
The potency of a drug component is commonly determined by:
a. HPLC
b. Titrimetric method
c. GC
d. Spectrophotometric method
a. HPLC
95
The index of refraction of a volatile oil is determined by using:
a. Spectrophotometer
b. Pycnometer
c. Refractometer
d. Polarimeter
c. Refractometer
96
A type of sampling which is permitted if the first one fails:
a. Double
b. Single
c. Both A and B
d. None of the above
a. Double
97
What is preferred for the standardization of permanganate?
a. Sodium oxalate
b. Sodium carbonate
c. Hydrogen peroxide
d. Sodium nitrate
a. Sodium oxalate
98
Instability will be accelerated by:
a. Temperature
b. Heat
c. Light
d. All of the above
d. All of the above
99
Assay of NaCl in table salt by precipitation as AgCl, filtration, drying, and weighing the reside is classified as:
a. Precipitimetry
b. Volhard method
c. Gravimetric analysis
d. Residual precipitimetry
c. Gravimetric analysis
99
An analyst who determines the strength, potency, and percentage purity of a drug or pharmaceutical product is performing:
a. Pharmaceutical assaying
b. Identification test
c. Pharmacopoeial test
d. Special test
a. Pharmaceutical assaying
100
Type of alkaloidal assay where the total alkaloids are determined
a. Ultimate
b. Specific
c. Extraction
d. Proximate
d. Proximate
101
The measurement of a base of a given sample by titration with a standard acid is known as:
a. Acidimetry
b. Compleximetry
c. Alkalimetry
d. Redox
a. Acidimetry
102
Which of the following substance is assayed by residual alkalimetric analysis?
a. Aspirin
b. Sodium hydroxide
c. Hydrochloric acid
d. Zinc oxide
a. Aspirin
103
The molecular weight of NaOH is 40. How many grams of NaOH pellets are needed to make 500 mL of 1.5 N solution?
a. 20
b. 30
c. 40
d. 60
b. 30
104
Which of the following is the most effective chemical substance in removing stains of potassium permanganate?
a. Oxalic acid
b. Sodium thiosulfate
c. Chalk
d. Vinegar
a. Oxalic acid
105
Which of the following indicators is the least used for acid-base titration?
a. Methyl orange
b. Phenolphthalein
c. Ferric alum
d. Methyl red
c. Ferric alum
106
Residual method titration with EDTA is applicable to what metal ion?
a. Calcium
b. Aluminum
c. Zinc
d. Magnesiu,
b. Aluminum
107
Chemical reactions that involve a change in the valence number of reacting substances
a. Neutralization
b. Complexation
c. Oxidation-reduction
d. Precipitation
c. Oxidation-reduction
108
A process wherein the sample is made to liberate iodine, which is then titrated with a standard solution of sodium thiosulfate
a. Volumetric titration
b. Back titration
c. Iodometry
d. Iodimetry
c. Iodometry
109
Malic acid represent in cherry juice may be determined by:
a. Indirect permanganate oxidation method
b. Direct permanganate oxidation method
c. Alkalimetry
d. Acidimetry
a. Indirect permanganate oxidation method
110
Iodometry is an indirect analysis of:
a. Oxidizing agents
b. Reducing agents
c. Acids
d. Bases
a. Oxidizing agents
111
The chemical factor used in calculation of percent purity of a substance in volumetric analysis
a. mEq weight
b. Molarity
c. Molality
d. None of the above
a. mEq weight
112
Adsorption indicators are used in:
a. Compleximetry
b. Acidimetry
c. Volumetric precipitation
d. Alkalimetry
c. Volumetric precipitation
113
The indicator used in permanganate titration
a. Methyl orange
b. Phenolphthalein
c. Permanganate solution
d. Methyl red
c. Permanganate solution
114
The indicator for EDTA direct titration of calcium carbonate:
a. Thymol blue
b. Hydroxynaphthol blue
c. Methyl red
d. Methylene blue
b. Hydroxynaphthol blue
115
To find the mEq factor of an oxidizing agent, divide the molecular weight by:
a. No. of electrons gained
b. No. of electrons lost
c. Valence
d. Replaceable hydrogen
a. No. of electrons gained
116
A term in compleximetry used to indicate a determination of a metal in the presence of another metal
a. Redox
b. Masking
c. Linking
d. Complexing
b. Masking
117
Two substances reacting upon reaching the endpoint must have the same:
a. Normality
b. Volume
c. No. of equivalents
d. Weight
c. No. of equivalents
118
The method of assay for sulfonamides is:
a. Acid-base titration
b. Gravimetric
c. Diazotization with nitrite
d. Redox titration
c. Diazotization with nitrite
119
Which of the following is a reducing agent?
a. Ascorbic acid
b. Potassium permanganate
c. Iodine
d. Hydrochloric acid
a. Ascorbic acid
120
Chemical analysis which determines the amount or percentage content of a certain component in a sample
a. Qualitative
b. Proximate
c. Quantitative
d. Gravimetric
c. Quantitative
121
The indicator used in the assay of weak acid reacting with a strong base is:
a. Methyl red TS
b. Methyl orange TS
c. Eriochrome black
d. Phenolphthalein
d. Phenolphthalein
122
The substance being analyzed is the:
a. Titrant
b. Indicator
c. Salt
d. Analyte
d. Analyte
123
Expression of concentration in volumetric EXCEPT:
a. Normality
b. Titer
c. Molarity
d. Molality
b. Titer
124
The assay procedures in volumetric precipitation were introduced by the following scientists, EXCEPT:
a. Arrhenius
b. Mohr
c. Fajan
d. Volhard
a. Arrhenius
125
The terms used when equivalent amount of each reactants have reacted are the following, EXCEPT:
a. End point
b. Equivalent point
c. Stoichiometric point
d. Theoretical point
a. End point
126
Component of a blank used in the assay of a substance are, EXCEPT:
a. Solvent
b. Reagent
c. Indicator
d. Analyte
d. Analyte
127
The color of phenolphthalein in vinegar
a. Pink
b. Yellow
c. Colorless
d. Orange
c. Colorless
128
The primary standard used in the assay of potassium permanganate
a. Hydrogen peroxide
b. Sulfuric acid
c. Potassium dichromate
d. Sodium oxalate
d. Sodium oxalate
129
An organic compound that changes from one color to another at a certain pH is called?
a. Test solution
b. Standard solution
c. Buffer
d. Indicator
d. Indicator
130
The assay of menadione sodium sulfate (Vitamin K) uses this method of analysis:
a. Gravimetric method
b. Acid-base method
c. Precipitation method
d. Redox titration
d. Redox titration
131
Precipitation method using potassium chromate TS as indicator and silver nitrate standard solution
a. Volhard
b. Fajan
c. Mohr
d. None of the above
c. Mohr
132
The titrant most commonly used for direct compleximetry titration
a. Zinc sulfate
b. EDTA
c. Silver nitrate
d. HClO4
b. EDTA
133
The masking agent used in the assay of Mg with EDTA in the presence of aluminum
a. Triethanolamine
b. Thioglycol
c. Potassium cyanide
d. Ammonium fluoride
b. Thioglycol
134
The substance used to form a film over the precipitated silver chloride particles in Volhard's method
a. Nitric acid
b. Sodium chloride
c. Triethanolamine
d. Nitrobenzene
a. Nitric acid
135
Assay of sodium nitrite is an example of:
a. Neutralization
b. Precipitation
c. Complexation
d. Redox method
d. Redox method
136
Ceric sulfate is a/an:
a. Precipitating agent
b. Oxidizing agent
c. Reducing agent
d. Complexing agent
b. Oxidizing agent
137
The valence number of Mn in KMnO4 is:
a. +2
b. +1
c. +5
d. +7
d. +7
138
The apparatus used to wash down drops of standard solution clinging to the tip of the buret
a. Babcock bottle
b. Cassia flask
c. Acetylization flask
d. Wash bottle
d. Wash bottle
139
The following are the methods of determining the endpoint of precipitimetry:
a. Use of adsorption indicators
b. Cessation of precipitation
c. Formation of turbidity
d. Appearance of turbidity
c. Formation of turbidity
140
The quality control manager is in-charge of the following sections, EXCEPT:
a. Analytical laboratory
b. Specifications and analytical development
c. Research and development
d. Biological testing laboratory
c. Research and development
141
Used to describe the overall organization body designed to assure product quality
a. Quality control
b. Quality assurance
c. Drug assaying
d. All of the above
b. Quality assurance
142
Serves as basis in accepting or rejecting the product
a. Standards
b. Specifications
c. A and B
d. None of the above
c. A and B
143
It shows mainly the conformance or non-conformance of the material to specifications
a. Variable defects
b. Attribute defects
c. Minor defects
d. Ocular defects
b. Attribute defects
144
Crack in the bottle is an example of __________ defect
a. Minor
b. Major
c. Critical
d. Serious
b. Major
145
Environmental monitoring is conducted by:
a. Material inspection section
b. Analytical laboratory
c. Biological testing laboratory
d. Specification and analytical laboratory
c. Biological testing laboratory
146
A basic quality function is that of deciding whether the product conforms to specifications. This function is generally called __________
a. Sampling
b. Standard
c. Acceptance
d. Inspection
c. Acceptance
147
It is a finite number of objects selected from a batch of a product
a. Sample
b. Sampling
c. Population
d. Inspection number
a. Sample
148
In a __________, a decision is made after the result of the second sampling is known
a. Single sampling
b. Double sampling
c. Multiple sampling
d. None of the above
b. Double sampling
149
The following are the numbers that must be specified in a sampling plan, EXCEPT:
a. Population
b. Sample
c. Acceptance
d. Rejection
d. Rejection
150
The following are the member countries that worked in the improvement of MIL-STD-105D, EXCEPT:
a. USA
b. UK
c. Canada
d. Australia
d. Australia
151
The MIL-STD-105D is used in sampling by:
a. Attribute
b. Variable
c. Defects
d. A and B only
a. Attribute
152
AQL is defined in the ABC standard as:
a. Maximum percent defectives
b. Acceptance quality level
c. Rejection number
d. Acceptance number
a. Maximum percent defectives
153
In a table for sample size cod, the inspection level _____ is used when less discrimination is needed
a. I
b. II
c. III
d. S
a. I
154
Which of the following statements is NOT true about the use of QC stickers?
a. Decision stickers are pasted on the top of quarantine stickers
b. Green stickers means approved for use
c. Green sticker should be pasted above the red sticker
d. Red sticker can be pasted even without removing yellow sticker
c. Green sticker should be pasted above the red sticker
155
Approved raw materials are audited to assure that they are rotated in such a manner that the old stocks are used first. This is known as:
a. FIFO
b. IFOF
c. FIPA
d. FOFI
a. FIFO
156
The following are examples of primary packaging components, EXCEPT:
a. Plunger
b. Seals
c. Boxes
d. Stripping
c. Boxes
157
Minimum criteria for acceptance of printed materials, EXCEPT:
a. Color
b. Expiration date
c. Cleanliness
d. Shape
b. Expiration date
158
Labeling requirements for drugs and cosmetics, EXCEPT:
a. Name
b. Lot number
c. Description
d. Business address
c. Description
159
Package insert include the following text, EXCEPT:
a. Action
b. Warning
c. Indication
d. Expiration date
d. Expiration date
160
One of the physico-chemical test conducted for containers
a. Stress crack resistance
b. Torque
c. Light transmission
d. Thermal analysis
d. Thermal analysis
161
Torque test is an example of:
a. Container control
b. Leak test
c. Closure control
d. Volatilization test
c. Closure control
162
Based on the stability of raw materials, reassay date assigned to flavoring agent is:
a. 6 months
b. 12 months
c. 24 months
d. 36 months
a. 6 months
163
This is generated to explain in detail the reason behind a procedure and proper sequence of steps to be done and how equipments are maximum performance
a. Manufacturing monograph
b. Quality control monograph
c. Batch record
d. Standard operating procedure
d. Standard operating procedure
164
It means any distinctive combinations of marking, letters, or numbers by which the history of the manufacture and control of a batch or lot of a product can be determined
a. Batch number
b. Lot number
c. Control number
d. All of the above
d. All of the above
165
Which of the following is NOT included in the minimum test requirement for solid preparations?
a. Friability
b. Weight variation
c. Hardness
d. Pourability
d. Pourability
166
Minimum requirements common to solid and liquid preparations, EXCEPT;
a. Color
b. Odor
c. Texture
d. Taste
c. Texture
167
For the sample size of 8 with AQL of 1.5, the acceptance number is:
a. 0
b. 1
c. 2
d. 3
a. 0
168
If AQP is 1.0 and the sample size is 13, the rejection number is:
a. 1
b. 2
c. 3
d. 4
a. 1
169
Ability of the formulation to remain within its physical, chemical, therapeutic, and toxicological specifications
a. Endurance
b. Stability
c. Purity
d. Friability
b. Stability
170
Results that agree closely with one another are said to be:
a. Accurate
b. Precise
c. Bias
d. A and B only
b. Precise
171
Which of the following given has the principal concern for residual contamination which could alter or adversely affect a subsequence product and cannot be detected by ordinary SOP methods?
a. Assay validation
b. Instrument validation
c. Process validation
d. Cleaning validation
d. Cleaning validation
172
High efficiency particulate air (HEPA) is an example of:
a. Mill
b. Filter
c. Dryer
d. Sprayer
b. Filter
173
Physical stability is of importance for formulator for the following reasons, EXCEPT:
a. Appearance
b. Uniformity
c. Bioavailability
d. Taste
d. Taste
174
A class of raw materials, which are to be subjected to tests and assays by the QC department and are not yet to be used in the production of pharmaceuticals
a. Approved for use materials
b. Rejected materials
c. Quarantined materials
d. In-process materials
c. Quarantined materials
175
A section of the warehouse which houses products which have been bottled, stripped, or blister packed, but not yet labeled or packed into boxes/cartons and are still awaiting the final disposition of the QC department
a. Finished goods section
b. In-process section
c. Returned goods section
d. Raw material section
b. In-process section
176
An important parameter in the quality control of tablets, shown to be related to tablet solubility properties
a. Thickness
b. Disintegration
c. Friability
d. Tensile strength
d. Tensile strength
177
An analyst who determines the strength, potency, and percentage purity of a drug pharmaceutical product is performing:
a. Pharmaceutical assaying
b. Pharmacopoeial testing
c. Identification test
d. Special method
a. Pharmaceutical assaying
178
One of the following is NOT an in-process control for tablets
a. Bioavailability
b. Weight variation
c. Hardness and thickness
d. Disintegration
a. Bioavailability
179
Content uniformity test is used to ensure which of the following quality in tablet products?
a. Disintegration
b. Bioavailability
c. Purity
d. Potency
d. Potency
180
Which of the following apparatus is the least accurate?
a. Pipet
b. Buret
c. Volumetric flask
d. Graduated cylinder
d. Graduated cylinder
181
Which of the following is the least true about cleaning volumetric apparatus?
a. Adherence of droplets to the wall of buret is positive evidence that the apparatus is dirty.
b. Hot cleaning solution should be used
c. Solution to be contained in it is used in final rinsing
d. All of the above
b. Hot cleaning solution should be used
182
Which of the following can be used in cleaning glass wares?
a. Sodium dichromate in sulfuric acid
b. Trisodium phosphate solution
c. Solution of synthetic detergent
d. All of the above
d. All of the above
183
The calibration of burets may be performed by means of:
a. Ostwald-calibrating pipet
b. Kiehl buret
c. Mohr buret
d. A and B only
d. A and B only
184
Apparatus used in cooling the sample or object and keeping them dry
a. Crucibles
b. Rubber policeman
c. Desiccator
d. Evaporating dish
c. Desiccator
185
The ideal type of buret used for bases
a. Glass buret
b. Teflon buret
c. Geissler's buret
d. Mohr buret
d. Mohr buret
186
It is an expression of the concentration for solution in terms of the number of milliequivalents per milliliter of solution
a. Molar
b. Normal
c. Molol
d. Formal
b. Normal
187
It is a process of determining the more accurate concentration of roughly prepared standard solution
a. Titration
b. Standardization
c. Calibration
d. Assay
b. Standardization
188
May be defined as the weight of a substance chemically equivalent to 1 mL of the standard solution
a. Titrant
b. Equivalent weight
c. Molarity
d. Titer
d. Titer
189
Which of the following substance/s is/are the least used as primary standard grade for standardization of basic solutions?
a. Sulfamic acid
b. Benzoic acid
c. Potassium biphthlate
d. THAM
d. THAM
190
The temperature specified in the USP and NF for volumetric measurement is:
a. 20°C
b. 25°C
c. 30°C
d. A and B only
b. 25°C
191
The theoretical point at which equivalent amounts of analyte and titrant have reacted is called:
a. End point
b. Stoichiometric point
c. Equivalence point
d. B and C only
d. B and C only
192
Salt and water are always the products in __________ reaction
a. Neutralization
b. Precipitation
c. Complexation
d. Redox
a. Neutralization
193
When a weak acid is titrated with a strong alkali, the indicator of choice is:
a. Methyl red
b. Methyl orange
c. Phenolphthalein
d. No indicator can be used
c. Phenolphthalein
194
Primary standard sodium carbonate must be heated at the temperature of about 270°C for one (1) hour prior to use to convert any __________ that might be present to anhydrous sodium carbonate
a. NaHCO3
b. H2CO3
c. CO2
d. H2O
a. NaHCO3
195
Which of the following can be used to standardize HCl solution?
a. Anhydrous sodium carbonate
b. Standard NaOH solution
c. Gravimetrically using AgNO3
d. All of the above
d. All of the above
196
What is the use of barium hydroxide in the preparation of standard NaOH solution?
a. Preservative
b. Precipitate any CO3 present in solution
c. Prevent reaction of NaOH with CO3
d. Catalyst
b. Precipitate any CO3 present in solution
197
In the preparation of a standard solution of NaOH more than 1 equivalent, 4.0 g of NaOH is weighed because it is:
a. Volatile
b. Effervescent
c. Hygroscopic
d. Corrosive
c. Hygroscopic
198
Milk of magnesia is assayed by:
a. Direct acidimetry
b. Direct alkalimetry
c. Residual acidimetry
d. Residual alkalimetry
c. Residual acidimetry
199
The most suitable indicator to use in the assay of sodium carbonate by direct acidimetry
a. Methyl orange
b. Methyl red
c. Phenolphthalein
d. Thymolphthalein
a. Methyl orange
200
The following substances can be assayed successfully only be residual method, EXCEPT:
a. ZnO
b. Aspirin
c. Magnesium carbonate
d. Acetic acid
d. Acetic acid
201
The USP macro method for determination of total nitrogen is:
a. Method I
b. Method II
c. Method III
d. Method IV
a. Method I
202
In Kjeldahl method of nitrogen determination, addition of which of the following can hasten the digestion of ammonia with sulfuric acid?
a. Potassium sulfate
b. Selenium
c. Copper sulfate
d. All of the above
d. All of the above
203
Standardization can be optional to:
a. 0.1 N oxalic acid
b. 0.1 N potassium dichromate
c. 0.1 N ceric sulfate
d. 0.1 N silver nitrate
d. 0.1 N silver nitrate
204
Roughly prepared standard solution of oxalic acid can be standardized using:
a. Pure iodine in KI
b. Standard NaOH solution
c. Standard permanganate solution
d. All of the above
d. All of the above
205
Metal ion indicator is used in:
a. Precipitimetry
b. Fajan method
c. Compleximetry
d. Cerimetry
c. Compleximetry
206
Standard solution used in precipitation method
a. Disodium edetate
b. Ammonium thiocyanate
c. AgCl
d. Ferric alum
b. Ammonium thiocyanate
207
Used to prevent one element from interfering in the analysis of another element
a. Nitrobenzene
b. Masking
c. Evaporation
d. Buffering
b. Masking
208
Assay of sodium nitrite can be done using:
a. Indirect permanganometry
b. Iodometry
c. Diazotization
d. All of the above
a. Indirect permanganometry
209
The end point using this indicator is illustrated by the formation of a secondary colored precipitate in:
a. Potassium chromate
b. Ferric alum
c. Fluorescein
d. Thiosulfate
a. Potassium chromate
210
Which of the following is added to maintain the pH of thiosulfate solution in optimum range for the stability of the solution?
a. Sodium carbonate
b. Sodium bicarbonate
c. Thymol
d. Chloroform
d. Chloroform
211
If starch TS is used as indicator, end point is illustrated by:
a. Appearance of blue color
b. Disappearance of blue color
c. Either
d. Neither
c. Either
212
The equilibrium constant for the reaction of metal ion with ligand is called:
a. Solubility constant
b. Solubility product constant
c. Stability constant
d. Ionization constant
c. Stability constant
213
What is the use of chloroform in sodium tetraphenylboron titration?
a. Solvent
b. Extraction indicator
c. Stabilizer
d. Catalyst
b. Extraction indicator
214
Can be assayed by direct titration with standard acetic acid:
a. Sodium bicarbonate
b. Dilute HCl
c. Ammonium chloride
d. KOH
d. KOH
215
Which of the following is/are true about auxiliary complexing agent?
I. They are ligands
II. They are masking agents
III. Hydroxynaphthol is an example
a. I only
b. I and III only
c. II and III only
d. I, II, and III
b. I and III only
216
Zn will not interfere in the analysis of Ca using EDTA at pH:
a. 2
b. 4
b. 8
d. 13
d. 13
217
Bacteria labile solution:
a. Sodium thiosulfate
b. Potassium permanganate
c. Potassium chromate
d. Oxalic acid
a. Sodium thiosulfate
218
The oxidation number of sulfur in sodium thiosulfate is:
a. 1
b. 2
c. 3
d. 4
b. 2
219
Drugs containing Ca can be assayed by:
a. Gravimetric method
b. Compleximetry
c. Complexometric method
d. All of the above
d. All of the above
220
Adsorption indicators are used in:
a. Precipitimetry
b. Compleximetry
c. Permanganometry
c. Neutralization
a. Precipitimetry
221
Which of the following cannot be assayed by sodium tetraphenylboron titration?
a. KCl
b. NH4Cl
c. AgNO3
d. NaCl
d. NaCl
222
Metal ion indicator that forms violet complex with Cu:
a. Dithizone
b. Pyridylazonaphthol
c. Hydroxynaphthol blue
d. Eriochrome black T
b. Pyridylazonaphthol
223
Which of the following is an oxidizing agent?
a. Thiosulfate
b. Arsenite
c. Bromate
d. Ferrous
c. Bromate
224
To remove the stain of potassium permanganate, the most effective chemical is:
a. Chlorox
b. Vinegar
c. Oxalic acid
d. Calamansi juice
c. Oxalic acid
225
HCl and calcium carbonate will react to form a primary product known as:
a. Carbonic acid
b. Calcium hydroxide
c. Calcium chloride
d. A and B only
c. Calcium chloride
226
Differentiating titration is applied to:
a. Alkali solution
b. Mixture of acids
c. Hard water
d. Oxidant-reductant
a. Alkali solution
227
Assay of selenium sulfide uses __________ method
a. Iodometric
b. Iodimetric
c. Koppeschaar's
b. Titration with hypoiodite
a. Iodometric
228
Can be used in the assay of sodium chloride:
a. Mohr method
b. Volhard method
c. Fajan method
d. All of the above
c. Fajan method
229
What is true about permanganate method:
I. Reaction is carried out in acidic solution
II. Standard permanganate is used as titrant in direct and indirect m ethod
III. No indicator is required
a. I and II only
b. II and III only
c. I and III only
d. I, II, and III
d. I, II, and III
230
Concentrated HCI (36.46 g/mol) has a purity of \ 36.5% w/w and sp.gr. 1.18; approximately how many milliliter of concentrated HCI is needed to prepare 500 mL of 0.2 N solution?
a. 3.1
b. 5.7
c. 6.8
d. 8.5
d. 8.5
231
What weight of 98.5% KHC8H4O4 (204 g/mol) is equivalent to 40.0 mL of 0.1 N NaOH?
a. 0.82 g
b. 0.83 g
c. 0.84 g
d. 0.85 g
b. 0.83 g
232
Exactly 30.2 mL of HCl was consumed in the titration of 1.6 gram of primary standard sodium carbonate (106 g/mol). What was the normal concentration of HCl solution?
a. 0.5
b. 1.0
c. 1.5
d. 2.0
b. 1.0
233
33.5 mL of 0.9998 N NaOH was used in the titration of 50 mL of HCl solution. Calculate the normality of HCl
a. 0.6689
b. 0.6779
c. 0.6699
d. 0.6969
c. 0.6699
234
A sodium bicarbonate (84 g/mol) tablet was dissolved in 200 mL of water and consumed 38.2 mL of 0.1009 N HCl. Calculate the % labeled claim. The labeled amount was 325 mg.
a. 99.0%
b. 99.4%
c. 99.6%
d. 99.8%
c. 99.6%
235
Calculate the MgO (40.30 g/mol) content of milk of magnesia, 12.32 g of which was dissolved in 50.0 mL of 1.034 N sulfuric acid producing a mixture that required 24.6 mL of 1.1255 N sodium hydroxide
a. 3.63%
b. 3.73%
c. 3.83%
d. 3.93%
d. 3.93%
236
A 4.052 g sample of HCl sp.gr. 1.18 required 44.15 mL of 0.9035 N NaOH in a titration. Calculate the Na2CO3 (106 g/mol) titer of the sample.
a. 0.5
b. 0.6
c. 0.7
d. 0.8
b. 0.6
237
Twenty sodium salicylate tablets labeled 325 mg were dispersed in sufficient water to make 200.0 mL. A 15.0 mL aliquot of the filtrate was titrated to a bromophenol blue end point in the usual way by 29.11 mL of 0.1 N HCl. Calculate the percent labeled amount of C7H5NaO3
a. 95.5%
b. 96.5%
c. 97.5%
d. 98.5%
a. 95.5%
238
Mixture of NaOH and Na2CO3 was assayed by double indicator method, 42.0 ml of a 0.0955 N HCI was consumed by 2.5 ml sample to produce end point. Calculate the % Na2CO3 if % NaOH is 4.12.
a. 3%
b. 4%
c. 5%
d. 6%
d. 6%
239
10 ml sample of diluted phosphoric acid consumed 35.0 ml of 1.002 N NaOH to produce a thymolphthalein end point. If the indicator blank is 0.7 ml, what is the % w/v H3PO4 (98)?
a. 16.2%
b. 16.5%
c. 16.8%
d. 17.0%
c. 16.8%
240
The experimental way of determining when equivalent amounts of reactants have reacted together is known as:
a. Titration
b. Stoichiometric method
c. Standardization
d. Equivalence point
a. Titration
241
Assay of atropine in belladonna is an example of:
a. Proximate assay
b. Ultimate assay
c. Both A and B
d. Neither A nor B
b. Ultimate assay
242
A solution of known concentration used to standardized another solution is:
a. Primary solution
b. Dilute solution
c. Secondary standard
d. B and C
a. Primary standard
243
The process of determining the exact concentration of a solution is:
a. Standardization
b. Neutralization
c. Redox
d. Acidimetry
a. Standardization
244
The type of ligand where EDTA belongs
a. Unidentate
b. Bidentate
d. Hexadentate
d. Tridentate
c. Hexadentate
245
Ferric alum TS is used as indicator in volumetric precipitation method if the titrant is:
a. AgNO3
b. BaCl2
c. NH4SCN
d. NH4Cl
c. NH4SCN
246
The pH of a solution is usually measured using:
a. Platinum electrode
b. Glass electrode
c. Mercury electrode
d. Calomel electrode
b. Glass electrode
247
Nuclear magnetic resonance is used for:
a. Radioisotopes
b. Irradiation
c. Identification of chemicals
d. A and B
c. Identification of chemicals
248
Potentiometry find application in:
a. Biologic assay
b. pH determination
c. Qualitative analysis
d. A and B
b. pH determination
249
In column chromatography, the separation of the sample mixture into a series of narrow bands in a column is:
a. Chromatogram
b. Eluant
c. Development
d. A and C
c. Development
250
Beer's plot in spectrometry is prepared to determine:
a. Absorbance of the sample
b. Wavelength to be used
c. Absorbance of the blank
d. Concentration of the sample
d. Concentration of the sample
251
A plot of absorbance against concentration of a standard drawn in a straight line is:
a. Charle's
b. Beer's
c. Lamber's
d. B and C
b. Beer's
252
The study of the optical activity of a substance is:
a. Polarimetry
b. Refractometry
c. Spectrophotometry
d. Potentiometry
a. Polarimetry
253
Chromatography can be used to separate compounds that are:
a. Colored
b. Colorless
c. Precipitate
d. A and B
d. A and B
254
A water content determination method that uses xylene tube is:
a. Gravimetry
b. Karl Fischer titrimetry
c. Azeotropic method
d. Dew point method
c. Azeotropic method
255
In infrared spectrometry, water is not used as a solvent for the sample because the water will:
a. Absorb IR radiation
b. Dissolve the sodium chloride cell holder
c. Not dissolve the sample
d. A and B only
d. A and B only
256
The law related to spectrometry wherein the powder of transmitted light decreases exponentially as the thickness of the solution increases arithmetically
a. Charle's
b. Beer's
c. Lamber's
d. Henry's
c. Lamber's
257
The alcohol content of volatile oil can be determined by:
a. Bisulfite method
b. Complexation process
c. Acetylization process
d. A and C only
a. Bisulfite method
258
Acetaminophen (600 mg) tablets contain nlt 90 % and nmt 110.0 % of the labeled amount
of C8H9NO2.
ASSAY:
Wt. of 20 tablets Acetaminophen =11.960 g
Wt. of reference standard: 102.2 mg diluted to 100 ml. 1 ml taken and diluted to 100 ml
Wt. of sample : 322.1 mg diluted to 100 ml. 0.04 ml taken and diluted to 100 ml
Absorbance of sample = 0.805
Absorbance of standard = 0.705
Based on the problem given, calculate the weight of one (1) tablet
a. 0.598
b. 0.569
c. 0.596
d. 0.599
a. 0.598
259
Acetaminophen (600 mg) tablets contain nlt 90 % and nmt 110.0 % of the labeled amount
of C8H9NO2.
ASSAY:
Wt. of 20 tablets Acetaminophen =11.960 g
Wt. of reference standard: 102.2 mg diluted to 100 ml. 1 ml taken and diluted to 100 ml
Wt. of sample : 322.1 mg diluted to 100 ml. 0.04 ml taken and diluted to 100 ml
Absorbance of sample = 0.805
Absorbance of standard = 0.705
Calculate the weight of reference standard in the final dilution based on the problem given
a. 0.01022 mg
b. 0.0102 mg
c. 0.0101 mg
d. 0.09090 mg
a. 0.01022 mg
260
Acetaminophen (600 mg) tablets contain nlt 90 % and nmt 110.0 % of the labeled amount
of C8H9NO2.
ASSAY:
Wt. of 20 tablets Acetaminophen =11.960 g
Wt. of reference standard: 102.2 mg diluted to 100 ml. 1 ml taken and diluted to 100 ml
Wt. of sample : 322.1 mg diluted to 100 ml. 0.04 ml taken and diluted to 100 ml
Absorbance of sample = 0.805
Absorbance of standard = 0.705
What is the weight of sample in the final dilution in mg based on your calculation on the problem given?
a. 0.0129
b. 0.01288
c. 0.0128
d. 0.0134
b. 0.01288
261
Acetaminophen (600 mg) tablets contain nlt 90 % and nmt 110.0 % of the labeled amount
of C8H9NO2.
ASSAY:
Wt. of 20 tablets Acetaminophen =11.960 g
Wt. of reference standard: 102.2 mg diluted to 100 ml. 1 ml taken and diluted to 100 ml
Wt. of sample : 322.1 mg diluted to 100 ml. 0.04 ml taken and diluted to 100 ml
Absorbance of sample = 0.805
Absorbance of standard = 0.705
What is the percent purity based on the problem given?
a. 99.02%
b. 92.90%
c. 90.29%
d. 90.60%
d. 90.60%
262
Acetaminophen (600 mg) tablets contain nlt 90 % and nmt 110.0 % of the labeled amount
of C8H9NO2.
ASSAY:
Wt. of 20 tablets Acetaminophen =11.960 g
Wt. of reference standard: 102.2 mg diluted to 100 ml. 1 ml taken and diluted to 100 ml
Wt. of sample : 322.1 mg diluted to 100 ml. 0.04 ml taken and diluted to 100 ml
Absorbance of sample = 0.805
Absorbance of standard = 0.705
What is the amount of acetaminophen in one (1) tablet?
a. 539.39 mg
b. 539.93 mg
c. 539.33 mg
d. 541.79 mg
d. 541.79 mg
263
Acetaminophen (600 mg) tablets contain nlt 90 % and nmt 110.0 % of the labeled amount
of C8H9NO2.
ASSAY:
Wt. of 20 tablets Acetaminophen =11.960 g
Wt. of reference standard: 102.2 mg diluted to 100 ml. 1 ml taken and diluted to 100 ml
Wt. of sample : 322.1 mg diluted to 100 ml. 0.04 ml taken and diluted to 100 ml
Absorbance of sample = 0.805
Absorbance of standard = 0.705
Calculate the potency/% labeled claim based on your calculation on the problem given
a. 89.90%
b. 89.99%
c. 89.09%
d. 90.30%
d. 90.30%
264
Acetaminophen (600 mg) tablets contain nlt 90 % and nmt 110.0 % of the labeled amount
of C8H9NO2.
ASSAY:
Wt. of 20 tablets Acetaminophen =11.960 g
Wt. of reference standard: 102.2 mg diluted to 100 ml. 1 ml taken and diluted to 100 ml
Wt. of sample : 322.1 mg diluted to 100 ml. 0.04 ml taken and diluted to 100 ml
Absorbance of sample = 0.805
Absorbance of standard = 0.705
Based on the problem given, what is your disposition?
a. Approved
b. Disapproved
c. Either
d. Neither
a. Approved
265
If the sample of beeswax has an acid value of 18.45 and an ester value of 74, what is the saponification number of the sample?
a. 85%
b. 98%
c. 88%
d. 92%
d. 92%
266
Determine the iodine value of a sample of olive oil weighing 0.21 g if 24.15 mL and 12 mL of 0.11 N sodium thiosulfate solution are required for the blank and residual titrations
a. 76%
b. 80%
c. 85%
d. 90%
b. 80%
267
Water content determination by Karl Fischer means:
a. Azeotropic
b. Titrimetric
c. Dew point
d. Electrolytic hydrometric
b. Titrimetric
268
Which of the following is the least in the Karl Fischer reagent?
a. Iodine
b. Pyridine
c. Sulfur dioxide
d. Ethanol
d. Ethanol
269
The minimum amount of moisture present in vegetable drugs should be __________% for the toluene
a. 1
b. 2
c. 3
d. 4
b. 2
270
If the wavelength of light is 10^-7 cm, this is equal to one __________
a. um
b. nm
c. Angstrom
d. m
b. nm
271
Which of the following components of energy is NOT involved in spectroscopy?
a. Electronic
b. Vibrational
c. Rotational
d. Translational
d. Translational
272
Calculate the water equivalence factor of Karl Fischer reagent if 179.5 mg sample of sodium tartrate dihydrate required 15.3 mL of KF reagent?
a. 1.8
b. 2.0
c. 2.2
d. 2.4
a. 1.8
273
A plot of absorbance against concentrations of a standard drawn in straight line is:
a. Spectral absorbance plot
b. Calibration curve plot
c. Beer's plot
d. Standardization plot
c. Beer's plot
274
The radiant energy required in the analysis of drugs using fluometry
a. UV
b. VIS
c. IR
d. All of the above
a. UV
275
The following are used in Fourier Transformed Infrared (FTIR) transmission technique, EXCEPT:
a. KBr pellet
b. NaCl pellet
c. Liquid petroleum
d. ATR
d. ATR
276
Nephelometric method for drug assaying is applied to:
a. Suspensions
b. Turbid solutions
c. Colloids
d. B and C only
d. B and C only
277
Which of the following substances is least applicable for ester value determination?
a. Fats
b. Essential oils
c. Alcohols
d. Fatty oils
c. Alcohols
278
The bisulfite method is used on assaying volatile oils to determine:
a. Aldehyde content
b. Acid content
c. Ester content
d. Alcohol content
a. Aldehyde content
279
The principle involved in the bisulfite method for assay of volatile oils is?
a. Formation of insoluble complex
b. Formation of turbidity
c. Formation of soluble product
d. Formation of a dense liquid
c. Formation of soluble product
280
In phenol content determination of volatile oil, the layer in the graduated neck of the cassia flask reached 2.7 mL from the sample of 10 mL after treatment with KOH solution. The % oil is?
a. 73%
b. 69%
c. 7.3%
d. 27%
d. 27%
281
Which of the following is NOT true about NMR?
a. C-NMR uses C-13
b. Very sensitive analytical technique
c. Sample probe is very small
d. TMS is used as reference standard
b. Very sensitive analytical technique
282
The adsorbent used in paper chromatography is:
a. Cellulose
b. Alumina
c. Silica
d. Charcoal
a. Cellulose
283
In using a spectrophotometer to measure the concentration of the sample, the following date were obtained: absorbance of the standard = 0.39, absorbance of the sample = 0.42, concentration of the standard = 15 mcg. The concentration of the sample is __________ mcg.
a. 16.15
b. 17.5
c. 15.75
d. 14.5
a. 16.15
284
The following are true about NMR spectroscopy, EXCEPT:
a. External magnetic field is applied to the sample
b. Radio wave is applied
c. Protium is used
d. Used for mixtures
d. Used for mixtures
285
Plane polarized light can be produced by using:
a. CaCO3
b. Polaroid
c. Icelandspar
d. All of the above
d. All of the above
286
Which of the following solvents is NOT used in NMR studies?
a. CCl4
b. CHCl3
c. Ether
d. CS2
b. CHCl3
287
Gypsum is added to silica which is used as adsorbent in TLC to serve as:
a. Hardening agent
b. Binder
c. Thickening agent
d. Lubricant
b. Binder
288
In gas chromatography, the stationary phase is:
a. Inert gas
b. Powdered adsorbent
c. High boiling liquid
d. Volatile oil
c. High boiling liquid
289
The operating speed for paddle in dissolution apparatus is:
a. 50 rpm
b. 100 rpm
c. 150 rpm
d. 200 rpm
a. 50 rpm
290
GC is utilized in the resolution of:
a. Volatile compounds
b. Biological compounds
c. Water soluble compounds
d. B and C only
a. Volatile compounds
291
In column chromatography, the resulting patterns with several bands is:
a. Chromatogram
b. Eluate
c. Spectrum
d. Adsorbate
a. Chromatogram
292
When the current flows from SHE to the substance, the electrode potential of __________ is designed for the substance?
a. +
b. -
c. 0
d. >
a. +
293
USP method 1 for iodine value determination is __________ method
a. Hanus
b. Wij's
c. Hubi's
d. Wagner's
a. Hanus
294
When alcoholic KOH is used to neutralize the acid and saponify the ester in 1 gm of the fat, the constant determined is:
a. Acid value
b. Ester value
c. Acetyl value
d. Iodine value
a. Acid value
295
Calculate the water content of streptomycin powder using 3.5 g sample. The water equivalence factor of the KF reagent was 4.6 and the volume consumed as 9.2 ml. The % water content was:
a. 1.2
b. 1.21
c. 12.1
d. 1.1
b. 1.21
296
In NMR analysis, many absorption peak are split into multiples because of the phenomenon known as:
a. Proton chemical shifts
b. Chemical exchange
c. Spin-spin coupling
d. Nuclear magnetic moment
c. Spin-spin coupling
297
The adsorbent commonly used in GC is:
a. Alumina
b. Calcium carbonate
c. Siliceous earth
d. Cellulose
c. Siliceous earth
298
The relative tendency of metals, ions of molecules to gain or lose electrons can be studied quantitatively by determination of:
a. Electrode
b. Electron charge
c. Heat absorbed
d. SHE
a. Electrode
299
Phenmetrazine HCl USP is assayed for chloride using 0.1 N AgNO3 and the endpoint is determined potentiometrically using:
a. Silver electrode as indicator electrode
b. HgSO4 as reference electrode
c. Ag reference and Hg2SO3 indicator electrode
d. A and B only
c. Ag reference and Hg2SO3 indicator electrode
