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Flashcards in Quick Pharm 3 Cards Deck (44):
1

Which 3 anti-fungals are effective at treating Aspergillus?

1. Amphotericin B
2. Voriconazole
3. Capsofungin

2

What is the MOA of the Triazoles?

Inhibit 14-α-sterol-demethylase - block Lanosterol to Ergosterol

3

What are the general SE of the triazoles

Hepatotoxicity, inhibit 2C, and 3A, N/V/D, headaches

4

Which anti-fungal targets the cell wall and what is the MOA?

Capsofungin - Blocks synthesis of β-(1,3)D-glucan - cell lysis

5

Which anti-fungal is effective against azole resistant strains?

Nystatin

6

Which anti-fungal is cidal due to a build up of squalene?

Terbinafine

7

What are the SE of Griseofulvin?

CYP inducer - CI w/ liver disease and penicillin allergies

8

What anti-parasitic treats neurocysticercosis?

Albendazole

9

What anti-parasitic treats schistosomoa?

Praziquantel

10

What 3 drugs treat amoebic dysentary?

1. Metronidazole
2. Paromomycin sulfate
3. Iodoquinol (w/ Metro if symp)

11

What anti-parasitic targets liver forms of malaria (hypnozoites)?

Primaquine

12

Cinchonism

Headache, visual disturbances, dizziness, tinnitus

13

What is the MOA of Chloroquine?

Build up of heme - drug accumulates in parasitized erythrocytes - (weak base) - acidic vacuoles

14

What is the MOA of Atovaquone

Inhibits malarial mito e transport --> blocks pyrimadine synthesis

15

What is the MOA of proguanil

Block pyrimidine synthesis by blocking malarial dihydrofolate reductase

16

Which anti-parasitic can have psychiatric effects?

Mefloquine

17

What anti-parasitic treats cyrptosporidium?

Nitazoxanide

18

What are the two anti-virals that treat flu?

Amantadine and Oseltamivir

19

What drug treats ophthalmic herpes?

Trifluridine

20

What drug treats herpes zoster?

Famciclovir

21

What two drugs treat CMV?

Ganciclovir and Foscarnet

22

Which two drugs bind to the RT domain of DNA Pol and what two diseases do they treat?

Lamivudine and Tenofovir - Hep B and HIV

23

What drug treats acyclovir-resistant herpes?

Foscarnet

24

What is the main side effect of ganciclovir?

Bone marrow suppression

25

What is the main side effect of foscarnet?

Renal fialure, seizures, electrolyte imbalance

26

What 3 drugs are used to treat Hep C?

Ribavirin, α-interferons, and boceprevir

27

What is Ribivirin's MOA?

Nucleoside analog that prevents GTP dep capping of viral mRNA

28

What is boceprevir's MOA?

Inhibits NS3 protease preventing the formation of infectious viral particles

29

What is the name of the protease inhibitor that treats AIDS?

Lopinavir (aspartic protease)

30

What is Ritonavirs MOA?

Inhibits CYP3A boosting the activity of lopinavir

31

What are the 3 NRTIs that treat AIDs?

Zidovudine, Emtricitabine, Abacavir?

32

What 3 drugs are used for lepromatous leprosy?

Dapsone, clofazimine and rifampin - 2 years

33

Which two anti-mycobacterials are metabolized by N-acetyltransferase?

Isoniazid and Dapsone

34

What 4 drugs are used for hospital-acquired MRSA?

1. Vancomycin
2. Linezolid
3. Daptomycin
4. Tigecycline

35

What 4 drugs are used to treat CA-MRSA?

1. Linezolid
2. Doxy/minocycline
3. Clindamycin
4. TMP/SMX

36

What class exhibits concentration dependent kiling and what are the SE?

Aminoglycosides (Gentamicin) - nephro/ototox and NM blockade - G- aerobic bacilli

37

What class exhibits AUC killing and what are their side effects?

Quinolones (Norfloxacin) - inhibit DNA gyrase - tendon rupture, EKG irregularities, peripheral neuropathies

38

What antibiotic causes muscle weakness?

Daptomycin - measure CPK levels - not good in lungs G+ only

39

What are two drugs that can be given for ESBLs?

1. Imapenem
2. Polymyxin B

40

What are the symptoms of opiate withdrawal?

6-12 hrs: Restlessness, drug seeking
12-24 hrs: Tremor, irritability, piloerection
24-72 hrs: Inc. HR/BP, involuntary movement of legs
Later: Autonomic hyperactivity w/ strong craving

41

What is morphine MOA?

Binds opioid R and decreases neuronal transmission

42

What two drugs are for initial control of manic symptoms?

Haloperidol

43

What does SSRI withdrawal look like?

Dizziness, lightehadedness, gait instability, insomnia, visual disturbances - appear 1-7 days after stopping

44

What is the end effect of TCAs?

Downregulation of receptors