Flashcards in Quick Pharm 3 Cards Deck (44):
Which 3 anti-fungals are effective at treating Aspergillus?
1. Amphotericin B
What is the MOA of the Triazoles?
Inhibit 14-α-sterol-demethylase - block Lanosterol to Ergosterol
What are the general SE of the triazoles
Hepatotoxicity, inhibit 2C, and 3A, N/V/D, headaches
Which anti-fungal targets the cell wall and what is the MOA?
Capsofungin - Blocks synthesis of β-(1,3)D-glucan - cell lysis
Which anti-fungal is effective against azole resistant strains?
Which anti-fungal is cidal due to a build up of squalene?
What are the SE of Griseofulvin?
CYP inducer - CI w/ liver disease and penicillin allergies
What anti-parasitic treats neurocysticercosis?
What anti-parasitic treats schistosomoa?
What 3 drugs treat amoebic dysentary?
2. Paromomycin sulfate
3. Iodoquinol (w/ Metro if symp)
What anti-parasitic targets liver forms of malaria (hypnozoites)?
Headache, visual disturbances, dizziness, tinnitus
What is the MOA of Chloroquine?
Build up of heme - drug accumulates in parasitized erythrocytes - (weak base) - acidic vacuoles
What is the MOA of Atovaquone
Inhibits malarial mito e transport --> blocks pyrimadine synthesis
What is the MOA of proguanil
Block pyrimidine synthesis by blocking malarial dihydrofolate reductase
Which anti-parasitic can have psychiatric effects?
What anti-parasitic treats cyrptosporidium?
What are the two anti-virals that treat flu?
Amantadine and Oseltamivir
What drug treats ophthalmic herpes?
What drug treats herpes zoster?
What two drugs treat CMV?
Ganciclovir and Foscarnet
Which two drugs bind to the RT domain of DNA Pol and what two diseases do they treat?
Lamivudine and Tenofovir - Hep B and HIV
What drug treats acyclovir-resistant herpes?
What is the main side effect of ganciclovir?
Bone marrow suppression
What is the main side effect of foscarnet?
Renal fialure, seizures, electrolyte imbalance
What 3 drugs are used to treat Hep C?
Ribavirin, α-interferons, and boceprevir
What is Ribivirin's MOA?
Nucleoside analog that prevents GTP dep capping of viral mRNA
What is boceprevir's MOA?
Inhibits NS3 protease preventing the formation of infectious viral particles
What is the name of the protease inhibitor that treats AIDS?
Lopinavir (aspartic protease)
What is Ritonavirs MOA?
Inhibits CYP3A boosting the activity of lopinavir
What are the 3 NRTIs that treat AIDs?
Zidovudine, Emtricitabine, Abacavir?
What 3 drugs are used for lepromatous leprosy?
Dapsone, clofazimine and rifampin - 2 years
Which two anti-mycobacterials are metabolized by N-acetyltransferase?
Isoniazid and Dapsone
What 4 drugs are used for hospital-acquired MRSA?
What 4 drugs are used to treat CA-MRSA?
What class exhibits concentration dependent kiling and what are the SE?
Aminoglycosides (Gentamicin) - nephro/ototox and NM blockade - G- aerobic bacilli
What class exhibits AUC killing and what are their side effects?
Quinolones (Norfloxacin) - inhibit DNA gyrase - tendon rupture, EKG irregularities, peripheral neuropathies
What antibiotic causes muscle weakness?
Daptomycin - measure CPK levels - not good in lungs G+ only
What are two drugs that can be given for ESBLs?
2. Polymyxin B
What are the symptoms of opiate withdrawal?
6-12 hrs: Restlessness, drug seeking
12-24 hrs: Tremor, irritability, piloerection
24-72 hrs: Inc. HR/BP, involuntary movement of legs
Later: Autonomic hyperactivity w/ strong craving
What is morphine MOA?
Binds opioid R and decreases neuronal transmission
What two drugs are for initial control of manic symptoms?
What does SSRI withdrawal look like?
Dizziness, lightehadedness, gait instability, insomnia, visual disturbances - appear 1-7 days after stopping