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PHARM 2 > Quinolones > Flashcards

Quinolones Flashcards

1
Q

What are quinolones

& examples of quinolones

A

derivatives of nalidixic acid

ciprofloxacin
levofloxacin
Gatifloxacin
Moxifloxacin
Gemifloxacin
Norfloxacin
Ofloxacin

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2
Q

MOA quinolones

A

inhibit DNA gyrase

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3
Q

Are quinolones bactericidal or static

A

bactericidal at therapeutic concentration

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4
Q

What is often resistant to quinolones

A

Staph aureus

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5
Q

Pharmacokinetics of quinolones

A

should be taken 2 hour before or 4 hr after food or antacids containing these cations

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6
Q

What should patients decrease when taking quinolones

A

Caffeine intake (due to inhibition of CYP1A2)

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7
Q

Contraindications Quinolones

A

children < 18 and in pregnancy and nursing mothers bc of effect on connective tissue

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8
Q

BBW quinolones

A

Tendonitis and rupture

Greater in patients > 60

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9
Q

Fluoroquinolones DOC

A

Complicated UTIs
Severe community acquired pneumonia (not cipro)

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PHARM 2 (22 decks)

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