Quiz 1 Flashcards
1
Q
What is the difference between a pharmacophore and auxacophore.
A
Pharmacophore- The Minimum structural unit required to interact, leading to a pharmacological response.
Auxacophore: Non essential portion of the drug, modulates the kinetics and selectivity of the drug.
2
Q
WHat are the fundamentals of medicinal chemistry
A
3
Q
carboxylic acid pKa
A
4-6
4
Q
pKa
A
9-11
5
Q
What is it and what is its pKa
A
4-6
6
Q
Name them and their pKas
A
Imidazole-7
Phenol- 9-11
Alkylthiol- 10-11
Guanidine-13-14
Amidine- 10-11
Alkyl Alcohol- 16
7
Q
Im a doll but shes a 7?
A
Imidazole has a pKa value of 7
8
Q
What are some forces involved in drug interactions
A
Hydrogen bonds
Halogen bonds
Aryl-Aryl Interactions
