Quiz 1 Flashcards
Tight junction
Controls solute flow
Uses occludins, Claudins, JAMS
Actin filaments
Gap junction
Small molecule transport between cells
Connexins
Adapters to other junctions
Desmosome junction
Strength
Desmosomal cadherins
Intermediate filaments
Adherens junction
Shape, tension
Cadherins
Actin filaments
What is integrin
It binds to VCAM in blood vessels during leukocyte extravasation
N-acetylglucosamine phosphotransferase does what?
Adds a phosphate to the 6th carbon of a mannose on an acid hydrolase (M6P) signal for lysosome targeting
What is clathrin
Coats vesicles forming a pit. Detaches from the vesicle when SNARE proteins protrude
What does dynamin do?
Polymerises around the neck of the vesicle causing the vesicle to break away and become free
Where is catalase found?
Inside peroxisomes
Where is PMP70 found?
In the membranes of peroxisomes
What are peroxins?
Import proteins
PTS1 pathway
4 steps
1 - matrix proteins with a PTS1 bind to cytoplasmic receptor Pex5
2 - Pex5 docks at the peroxisomal membrane via a docking complex consisting of Pex13 and Pex14
3 - pex2, pex10 and pex12 recycle Pex5
4 - Pex1 and pex6 remove ubiquitin from pex5
What kind of glycosylation occurs in the golgi complex?
N linked (complex) O linked
What sort of glycosylation occurs in the endoplasmic reticulum?
Simple N linked
What is dolichol?
In the endoplasmic reticulum, preformed sugars are attached to a dolichol molecule. Oligosacchryltransferase removes the sugar from dolichol
What is I-cell disease?
Lack of N-acetylglucosamine phosphotransferase, resulting in no M6P signals on acid hydrolases
