Quiz 2

Question 1

Cyclosporin A

Answer 1

-fungal antibiotics that affects T cell proliferation and early differentiation of T cells, especially helper inducer cells. IL-12 and IFN-gamma is inhibited

    Side Effects- kidney/liver toxicity

Question 2

FK-506

Answer 2

antibiotic used for liver transplants mainly but also kidney, heart, and liver

Question 3

Prednisone

Answer 3

corticosteroid

inhinits T cell homing, decreases response of macs and lymphokines,  

inhibits IL-12 and IFN Gamma  

affect mainly T cells

Question 4

Azathioprine

Answer 4

cytotoxic
blocks nucleic acid production

affects mainly T cells and NK cells  

Side Effect/Con 

    great toxicity 

    bone marrow depression 

    sterility 

    GI bleeding 

    infection 

    increased risk of malignancies

Question 5

cyclophosphamide

Answer 5

cytotoxic
stops B cell and antibody production

side effects 

    bladder toxicity  

    sterility 

    carcinogenic

Question 6

Bruton’s disease

Answer 6

no/ few B cells or antibodies

Question 7

CVID

Answer 7

helper T cell activity over all low IgG/IgA

Question 8

Hyper IgM caused by

Answer 8

defective CD40 on B Cells/ CD40L on T cells

Question 9

Wiskott-Aldrich Syndrome (WAS)

Answer 9

WAS helps move T cell cytoskeleton

Defective T cells

Question 10

Ataxia-telangiectasia

Answer 10

ATM is involved in DNA repair

if ATM is damaged, lymphocyte development is impaired

Question 11

50% of SCID

Answer 11

gamma cytokine receptor is defective

T/NK cells don’t work properly

Question 12

Leukocyte Adhesion Deficiency (LAD)

Answer 12

phagocytic deficiency

- no LFA/integrin for endothelial binding

Question 13

Chediak- Higashi

Answer 13

phagocytic

phagosomes don’t fuse w/ lysososomes

Question 14

Chronic Granulomatous Disease

Answer 14

defect in NADPH oxidase

Question 15

Job’s syndrome

Answer 15

Th cells can’t make IFN-gamma

Question 16

Hereditary angioedema

Answer 16

C1q inhibtor is deficient

continuous complement activation

Question 17

Paroxysmal Nocturnal Haemoglobinuria

Answer 17

Decay Accelerating factor deficiencies leads to lysis of red blood cell precursors

Question 18

which complement deficiency is most serious

Answer 18

C3