Quiz 3 Flashcards
First pass metabolism in the small intestinal wall by CYP450 enzymes would affect drugs metabolized by which family of the CYP450 group?
CYP3A
(Includes CYP34A) represents greatest amount of CYP450 enzymes in the intestine
For a genetic polymorphism to exist, it needs to be present in what percent of the population?
1%
The coadministration of newly prescribed clarithromycin with which medicine already currently being used would result in an increased level of the medicine ?
Digoxin
Dig absorption is inhibited by clarithromycin and several other drugs. This occurs by clarithromycin inhibition of the efflux activities of P-gp
Cigarette smoke induces the production of which CYP450 enzyme?
CYP1A2
The transporter that is known as a drug “efflux pump” that removes drugs from the body (intestine and kidney) is called _________.
The P-glycoprotein pump
The first polymorphism documented that altered the metabolism of drugs was for which enzyme?
NA2
A drug that increases the quantity or activity of a metabolic enzyme that in turn increases the metabolism of a drug is called a/an A. Inhibitor B. Inducer C. Substrate D. All of the above
B. Inducer
MicroRNAs are now targets against several diseases, notably cancer and Hepatitis C. Which of the following best describes microRNAs?
A. MiRNAs are short in length
B. MiRNAs bind to the mRNA sequences
C. MiRNAs can prevent the attachment of the tRNAs resulting in prevention of translation of the mRNA into proteins
D. All of the above
D. All of the above.
From the ethnopharmocological point of view, which group is most impacted by a polymorphism in the CYP3A4 family? A. Caucasians B. African Americans C. Hispanic population D. Chinese
B. African Americans
Children deficient in CYP2D6 are susceptible to increased morbidity and mortality when they take which drug? A. Aspirin B. Dextromethorphan C. Amoxicillin D. Codeine
B. Dextromethorphan
