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Immunology and serology > quiz 3 > Flashcards

quiz 3 Flashcards

(48 cards)

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1
Q

What type of nucleic acids does Hep B have

A

DNA

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2
Q

What are the markers for Hep A

A

IgM anti- HAV

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3
Q

When testing for Hep A, if IgM is detected what does this indicate

A

current infection or recent exposure

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4
Q

When testing for Hep A, if IgG is detected what does this indicate

A

immunity; have been vaccinated

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5
Q

What are the four ACUTE serological markers

A

Anti- HAV, HbsAG, Anti-HBc, Anti- HCV

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6
Q

What is anti- HAV directed against

A

its an IgM antibody directed against Hep A

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7
Q

What is HBsAG

A

hep B surface antigen

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8
Q

what is anti-HBc directed against

A

its an IgM antibody directed against hep B core antigen

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9
Q

what is anti-HCV

A

antibody against hep C

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10
Q

What are antibody markers for hbv

A

anti- HBc, anti- HBe, anti- HBs

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11
Q

if anti- HBc is present, what does this indicate

A

current or recent acute infection

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12
Q

What is anti- HBe

A

antibodies directed against HBeAG

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13
Q

If anti- HBe is present, what does this indicate

A

recovery from hbv

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14
Q

If HBeAG is present (the antigen), what does this indicate

A

pt is highly infectious; marker of active viral replication

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15
Q

What markers are on hep b virus surface and in core

A

core protein, b-e protein, surface antigen (HBsAG)

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16
Q

What does presence of HBsAG indicate

A

marker for active hbv infection

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17
Q

If positive for HbsAG and anti- HBc IgM, what is the dx

A

acute hep b infection

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18
Q

What is first hbv marker to appear

A

core protein

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19
Q

What is second hbv marker to appear

A

anti- HBc (against core protein)

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20
Q

What is third hbv marker to appear

21
Q

What is fourth hbv marker to appear

Study These Flashcards
A

anti- HBs IgG

22
Q

When is an individual considered chronically infected with hbv

Study These Flashcards
A

if HBsAG is present for more than six months

23
Q

Which three markers determine the stage of chronic infection

Study These Flashcards
A

HBsAG, HBeAG, anti-HBc IgG

24
Q

Testing which markers determines hbv immunity

Study These Flashcards
A

anti- HBs (antibody against surface antigen)

25
What is hbv vaccine contain
surface antigen
26
Which protein complex is anchored into HIV envelope
gp120/gp41
27
Which proteins surround the HIV genome
p24 and p17
28
Which three enzymes are in the HIV nucleocapsid
protease, reverse transcriptase, integrase
29
Which three encoding genes are in the HIV genome
gag, pol, env
30
Which co-receptors are required for gp120 to attach to CD4 on host, allowing virus to enter
CXCR4 and CCR5
31
Asymptomatic stage of HIV
flu like symptoms, lymphadenopathy. test for p24
32
Seroconversion stage of HIV
detectable antibodies from 2 weeks - 6 months
33
Latent phase of HIV
lasts up to 10 yrs, CD4 destroyed slowly, viral RNA and Ab detected
34
Clinical AIDS stage
serious infections
35
What concentration of CD4 T cells is indicative of HIV
< 200 cells/uL
36
What is done for HIV screening test and what is detected
ELISA, detects antibodies against gp120
37
What is confirmatory test for HIV and what is detected
Western blot, detects IgG to HIV
38
Four types of tests used in dx and monitoring of HIV
CD4 T cell enumeration (see if < 200 cells/ uL) HIV antibody detection (ELISA and western blot) HIV antigen detection (early stages) HIV nucleic acid detection (RT-PCR)
39
What is principle of ELISA screening for HIV
detects HIV antibody in serum to vital antigens coated onto a solid support
40
What is principle of western blot
separated HIV antigens, p24, gp41, and gp120/160 on western blot media is treated with pt serum; at least two of the antigens should be detected to call result positive
41
What is reagin
antibody against cardiolipin; non treponemal antibody
42
What are nontreponemal tests for syphilis
VDRL, RPR
43
What do VDRL and RPR detect
reagin
44
What reaction occurs in VDRL and RPR
flocculation- precipitation that produces clumping of fine cardiolipin particles
45
What are confirmatory tests for syphilis
most common is FTA-ABS (fluorescent treponemal absorption)-- detects antibodies against T. pallidum
46
Does VDRL display sensitivity in latent patients
no
47
How is lyme dx
ELISA; if positive confirm with western blot
48
Which band should be present to identify lyme
41 kD

Immunology and serology (4 decks)

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