Quiz 3 crossword

Question 1

_______ cells are active phagocytes that engulf bacteria, old RBCs, toxins, debris from blood flowing through sinusoids

Answer 1

Kuppfer

Question 2

Bilirubin conjugated w/ 2 glucuronic acid molecules

Answer 2

Direct

Question 3

A chronic, lifelong conditinon in which the body cannot produce or cannot use insulin properly

Answer 3

Diabetes mellitus

Question 4

Enzyme that helps digest carbs

Answer 4

Amylase

Question 5

Plot in which reverse of Vmax = y-intercept

Answer 5

Lineweaver-Burk

Question 6

Chronic liver disease characterized pathologically by fibrosis and conversion of normal liver architecture into structurally abnormal lobules

Answer 6

Cirrhosis

Question 7

Condition characterized by yellow discolouration of skin, sclera, mucous membranes caused by elevated bilirubin levels

Answer 7

Jaundice

Question 8

Waste product from the degradation of the heme portion of old RBCs

Answer 8

Bilirubin

Question 9

The product of amino acid and protein catabolism; elevated levels associated w/ impending hepatic coma and Reye;s syndrome

Answer 9

Ammonia

Question 10

Indicated by negative HbsAg and Anti-HBc and positive HBs antibody

Answer 10

Immunization

Question 11

The stoppage or obstruction of the flow of bile from intrahepatic causes, obstruction of bile duct by gallstones, or any process that blocks the bile duct

Answer 11

Cholestasis

Question 12

Development of both HBs and HBc antibodies indicates

Answer 12

Recovery

Question 13

Autosomal recessive disorder resulting in increased serum total bilirubin and presence of bilirubin in the urine

Answer 13

Dubin-Johnson

Question 14

Enzyme that is higher in post-hepatic obstruction compared to intrahepatic obstructions

Answer 14

GGT

Question 15

Analytical method involves hydrolysis of starch to release iodine

Answer 15

Amyloclastic

Question 16

Tablet test for analysis of bilirubin in urine

Answer 16

Ictotest

Question 17

Inhibition which results in increased slope and y-intercept when plotted on Lineweaver-Burk plot

Answer 17

Non-competitive

Question 18

Sudden inflammation of the pancreas

Answer 18

Acute pancreatitis

Question 19

Autosomal recessive disorder of copper metabolism associated with low levels of ceruloplasmin

Answer 19

Wilson’s disease

Question 20

An inflammatory condition of the pancreas most often caused by excessive alcohol consumption

Answer 20

Chronic pancreatitis

Question 21

Principle based on the production of a colored product in bilirubin analysis

Answer 21

Diazo

Question 22

The geometric shape of a protein composed of a single polypeptide chain

Answer 22

Tertiary

Question 23

Liver enzyme that catalyzes the reaction of aspartate and oxoglutarate

Answer 23

AST

Question 24

Transmission of Hep A and E viruses

Answer 24

Fecal-oral

Question 25

Group of enzymes that catalyze the transfer of amino groups

Answer 25

Aminotransferases

Question 26

Aminotransferase that is more liver-specific and diagnostic in hepatocellular disorders

Answer 26

ALT

Question 27

________ syndrome: unconjugated hyperbilirubinemia involving a protein with active transport of bilirubin by ligandin through the hepatocyte cell membrane to the microsome

Answer 27

Gilbert's disease

Question 28

Result of bacterial action on conjugated bilirubin

Answer 28

Urobilinogen

Question 29

Condition differentiated from other cases of increased amylase by amylase creatinine clearance ratio

Answer 29

Macroamylasemia

Question 30

Condition that occurs when pancreas fails to provide the necessary amount of digestive enzymes

Answer 30

Pancreatic insufficiency

Question 31

Jaundice as a result of increased hemolysis and excessive destruction of RBCs leading to increased bilirubin

Answer 31

Pre-hepatic

Question 32

Enzyme that catalyzes the breakdown of fats to fatty acids and glycerol

Answer 32

Lipase

Question 33

Virus that is dependent on another virus to replicate

Answer 33

HDV

Question 34

Enzyme which oxidizes bilirubin to biliverdin

Answer 34

Bilirubin oxidase

Question 35

Enzymes that differ in amino acid sequences but catalyze the same chemical reaction

Answer 35

Isoenzyme

Question 36

Lined by Kuppfer cells

Answer 36

Sinusoid

Question 37

The concentration of substrate which permits the enzymes to achieve half Vmax

Answer 37

Km

Question 38

Particle of HBV which consists of a core and an envelope

Answer 38

Dane

Question 39

Antibody usually indicating acute infection of hepatitis

Answer 39

IgM

Question 40

Mumps or swelling of the major salivary glands

Answer 40

Parotitis

Question 41

Fibrosing disease leading to non-alcoholic steatohepatitis

Answer 41

NAFLD

Question 42

Enzyme that can be used to differentiate bone disorders from liver disorders

Answer 42

GGT

Question 43

Location in the liver between a hepatocyte and a sinusoid

Answer 43

Space of Disse

Question 44

Reaction that has a rate independent of the concentration of the reactant(s)

Answer 44

Zero-order

Question 45

Infiltration of liver cells with fat

Answer 45

Steatosis

Question 46

Enzyme that is elevated in liver and bone disorders

Answer 46

ALP

Question 47

Medications that may interfere with amylase and lipase analysis

Answer 47

Opiates

Question 48

Substance (other than substrate) whose presence is essential for activity of an enzyme

Answer 48

Cofactor

Question 49

Water soluble end product of toxic ammonia

Answer 49

Urea

Question 50

Enzymes which catalyze the joining of specified molecules or groups by a double bond

Answer 50

Lyase

Question 51

Period when environment is adjusting a reaching equilibrium

Answer 51

Lag