Quiz 3 flash cards

Question 1

What ways can a drug be transported into a cell?

Answer 1

Diffusion
Facillitated diffusion
Active transport

Question 2

What charactoristics make dissolution the late limiting step of drug metabolism?

Answer 2

Solubility of drug
Size of particle
Surface area
Crystalline and salt drug formation
Rate of disintegration

Question 3

What are the charactoristic of pH-partiition for drug absorption?

Answer 3

Biological membranes act like lipid barriers
Un-ionized forms of drug is better absorbed
Most are absorbed by passive diffusion
rate and amount of drug absorption are related to oil-water partition coefficent
Weak acids and neutral drugs not usually absorbed in the stomach
Basic drugs are normally absorbed in the stomach

Question 4

What are the hallmarks of cancer?

Answer 4

Sustained proliferative signaling
Evading growth suppressors
Activating invasion/metasis
Enable replicative immortality
Induce angiogenesis
Resisting cell death

Question 5

What is the molecular target for Mustard agents?

Answer 5

DNA

Question 6

What is the MOA of Mustard agents?

Answer 6

Alkylate and crosslink the DNA

Question 7

What type of cancer are Mustard agents used for?

Answer 7

Multiple

Question 8

What is the molecular target of Mytomycin C?

Answer 8

DNA

Question 9

What is the MOA for Mytomycin C?

Answer 9

Alkylate and cross link DNA

Question 10

What type of cancer does Mytomycin C treat?

Answer 10

Stomach and Intestinal Cancer

Question 11

What is the molecular target for Platinum Drugs

Answer 11

DNA

Question 12

What is the MOA of Platinum drugs?

Answer 12

Alkylate and cross link DNA

Can alkylate the protein in the protein-DNA crosslink

Question 13

What is the molecular target for Anthracyclins?

Answer 13

Topo 2a

Question 14

What is the MOA for Anthracyclin?

Answer 14

Stabilizes transient cleavage complex with DNA

Question 15

What cancers are treated with Anthracyclin?

Answer 15

Breast, endometiral, acute leukemia, cervical, stomach, lymphoma

Question 16

What is the molecular target for Etoposide?

Answer 16

Topo 2A

Question 17

What is the mechanism of action for Etoposide?

Answer 17

Stabilizes transient cleavage complex with DNA

Question 18

What cancers are treated with Etoposide?

Answer 18

Lung and Testicular

Question 19

What are the molecular target of ICRF-193?

Answer 19

Topo 2A and chelate iron preventing ROS production

Question 20

What is the MOA of ICRF-193?

Answer 20

Stabilized closed clamp complex with DNA

Question 21

What is the molecular target of Imatinib?

Answer 21

BRC-ABL

Question 22

What is the MOA of Imatinib?

Answer 22

Competitive BCR-ABL inhibitor- makes ABL inactive

Question 23

What cancers can be treated by Imatinib?

Answer 23

Mainly leukemia ALL,CEL,CML

Question 24

What is the molecular target for Dasatinib?

Answer 24

BCR-ABL

Question 25

What is MOA of Dasatinib?

Answer 25

Binds to active ABL

Question 26

What cancers can be treated by Dasatinib?

Answer 26

Imatinib resistant Leukemia and Philadelpha chromosome positive

Question 27

What is the clinical significance of statins?

Answer 27

Lower LDL and sometime increase HDL cholesterol

Question 28

How do statins work?

Answer 28

They mimic the transition state Mevaidyl-CoA

Question 29

Which statins are natural products?

Answer 29

Compacitin and Simvastatin

Question 30

Which statins are SYnthetic products?

Answer 30

Fluvastatin, atorvastatin, rosuvastatin, cerivastatin

Question 31

What charactorist to all statins have in common?

Answer 31

They have HMG-like functional groups