Quiz 4? (ID, HTN, Pain) Flashcards
(39 cards)
What polymorphic enzyme affects opioid efficacy?
CYP2D6
What are the nonfunctional alleles for CYP2D6?
4, 5, 6
What mutation makes a CYP2D6 allele have increased function?
More copies of *1/2
What population is more likely to be UM at CYP2D6?
African patients
What populations are more likely to be poor metabolizers at CYP2D6?
Hispanic, African, White (not Asian)
What metabolizers (poor, intermediate, ultrarapid) should avoid use of opiates?
PM, UM
Which opiates have a clinical recommendation based on pharmacogenomics
Codeine, dihydrocodeine
Not oxycodone, hydrocodone, or tramadol
Polymorphisms in the u-opioid receptor MOR increase/decrease response to morphine?
Decrease
COMT degrades ____
NTs
COMT homozygous ___ has ____ response to morphine
Met, higher (lower morphine requirements)
Which ADRB1 mutation location causes loss of function: 389 or 49?
389
ADRB1 389 mutation is more common in african americans or other populations?
African Americans
Which ADRB1 mutation causes gain of function? 389 or 49
49
How do the ADRB2 mutations affect receptors?
downregulate them
Do the ADRB2 mutations cause loss or gain of function?
Loss of function
What populations are more likely to have Gly16Arg mutation?
Asians/AAs
What populations are more likely to have Gln 27 Glu mutation?
Caucasians/AAs
ADD1 SNP causes blood pressure raising or lowering effects?
Lowering
Rs145038 is found near _____
FGF5
What’s the significance of FGF5?
Response to HCTZ and atenolol–one SNP (TT) had better response to atenolol, the other (CC) to HCTZ
Which Cyp metabolizes efavirenz?
CYP2B6
What is the etoxicity associated with poor efavirenz metabolism?
QT Prolongation
How does efavirenz cause its toxicity?
Prolongs AP by inhibiting K repolarizing current
What are the LOF alleles on CYp2B6?
*6,18
