Flashcards in Quiz 4? (ID, HTN, Pain) Deck (39):
What polymorphic enzyme affects opioid efficacy?
What are the nonfunctional alleles for CYP2D6?
4, 5, 6
What mutation makes a CYP2D6 allele have increased function?
More copies of *1/2
What population is more likely to be UM at CYP2D6?
What populations are more likely to be poor metabolizers at CYP2D6?
Hispanic, African, White (not Asian)
What metabolizers (poor, intermediate, ultrarapid) should avoid use of opiates?
Which opiates have a clinical recommendation based on pharmacogenomics
(Not oxycodone, hydrocodone, or tramadol)
Polymorphisms in the u-opioid receptor MOR increase/decrease response to morphine?
COMT degrades ____
COMT homozygous ___ has ____ response to morphine
Met, higher (lower morphine requirements)
Which ADRB1 mutation location causes loss of function: 389 or 49?
ADRB1 389 mutation is more common in african americans or other populations?
Which ADRB1 mutation causes gain of function? 389 or 49
How do the ADRB2 mutations affect receptors?
Do the ADRB2 mutations cause loss or gain of function?
Loss of function
What populations are more likely to have Gly16Arg mutation?
What populations are more likely to have Gln 27 Glu mutation?
ADD1 SNP causes blood pressure raising or lowering effects?
Rs145038 is found near _____
What's the significance of FGF5?
Response to HCTZ and atenolol--one SNP (TT) had better response to atenolol, the other (CC) to HCTZ
Which Cyp metabolizes efavirenz?
What is the etoxicity associated with poor efavirenz metabolism?
How does efavirenz cause its toxicity?
Prolongs AP by inhibiting K repolarizing current
What are the LOF alleles on CYp2B6?
What CYP metabolizes voriconazole?
Which CYP2C19 are LOF?
Which CYp2C19 polymorphisms are GOF?
Choose an alternative agent for voriconazole for which populations of metabolizers? (Ultrarapid, poor, rapid, normal?)
UM, PM, RM
What infectious disease meds have CPIC guidelines?
Ribaviran/Peginterferon treatment? Viral genotype 1 v. viral genotype 2
Type 1: 48 weeks, less chance of success
Type 2: 24 weeks, higher chance of success
IFNL3 mutation affects what system?
JAK-STAT, immune system modulating
IFNL3 polymorphism (T) reduces/increases chance of success?
CCR5 affects what disease?