Quiz 4? (ID, HTN, Pain) Flashcards Preview

Pharmacogenomics > Quiz 4? (ID, HTN, Pain) > Flashcards

Flashcards in Quiz 4? (ID, HTN, Pain) Deck (39):
1

What polymorphic enzyme affects opioid efficacy?

CYP2D6

2

What are the nonfunctional alleles for CYP2D6?

4, 5, 6

3

What mutation makes a CYP2D6 allele have increased function?

More copies of *1/2

4

What population is more likely to be UM at CYP2D6?

African patients

5

What populations are more likely to be poor metabolizers at CYP2D6?

Hispanic, African, White (not Asian)

6

What metabolizers (poor, intermediate, ultrarapid) should avoid use of opiates?

PM, UM

7

Which opiates have a clinical recommendation based on pharmacogenomics

Codeine, dihydrocodeine
(Not oxycodone, hydrocodone, or tramadol)

8

Polymorphisms in the u-opioid receptor MOR increase/decrease response to morphine?

Decrease

9

COMT degrades ____

NTs

10

COMT homozygous ___ has ____ response to morphine

Met, higher (lower morphine requirements)

11

Which ADRB1 mutation location causes loss of function: 389 or 49?

389

12

ADRB1 389 mutation is more common in african americans or other populations?

African Americans

13

Which ADRB1 mutation causes gain of function? 389 or 49

49

14

How do the ADRB2 mutations affect receptors?

downregulate them

15

Do the ADRB2 mutations cause loss or gain of function?

Loss of function

16

What populations are more likely to have Gly16Arg mutation?

Asians/AAs

17

What populations are more likely to have Gln 27 Glu mutation?

Caucasians/AAs

18

ADD1 SNP causes blood pressure raising or lowering effects?

Lowering

19

Rs145038 is found near _____

FGF5

20

What's the significance of FGF5?

Response to HCTZ and atenolol--one SNP (TT) had better response to atenolol, the other (CC) to HCTZ

21

Which Cyp metabolizes efavirenz?

CYP2B6

22

What is the etoxicity associated with poor efavirenz metabolism?

QT Prolongation

23

How does efavirenz cause its toxicity?

Prolongs AP by inhibiting K repolarizing current

24

What are the LOF alleles on CYp2B6?

*6,18

25

What CYP metabolizes voriconazole?

2c19

26

Which CYP2C19 are LOF?

*2/3

27

Which CYp2C19 polymorphisms are GOF?

*17

28

Choose an alternative agent for voriconazole for which populations of metabolizers? (Ultrarapid, poor, rapid, normal?)

UM, PM, RM

29

What infectious disease meds have CPIC guidelines?

Abacavir
Atazanavir
Ribavirin/Peginterferon
Voriconazole

30

Abacavir mutation?

HLA-B

31

Abacavir toxicity?

SJS/TEN

32

Atazanavir mutation?

UGT1A1

33

Atazanavir toxicity?

Jaundice

34

Ribavirin/Peginterferon mutation?

IFNL3

35

Ribaviran/Peginterferon treatment? Viral genotype 1 v. viral genotype 2

Type 1: 48 weeks, less chance of success
Type 2: 24 weeks, higher chance of success

36

IFNL3 mutation affects what system?

JAK-STAT, immune system modulating

37

IFNL3 polymorphism (T) reduces/increases chance of success?

Reduces success

38

CCR5 affects what disease?

HIV

39

32 homozygotes are more/less resistant to R5 HIV?

More resistant